View source for Mesonephric remnant of the prostate gland

'''Mesonephric remnant hyperplasia of the prostate gland''', also '''mesonephric remnant''', is rare benign finding in the [[prostate gland]] that can be confused with [[malignancy]].

==General==
*Very rare.<ref name=pmid21606823>{{Cite journal  | last1 = Chen | first1 = YB. | last2 = Fine | first2 = SW. | last3 = Epstein | first3 = JI. | title = Mesonephric remnant hyperplasia involving prostate and periprostatic tissue: findings at radical prostatectomy. | journal = Am J Surg Pathol | volume = 35 | issue = 7 | pages = 1054-61 | month = Jul | year = 2011 | doi = 10.1097/PAS.0b013e318218df97 | PMID = 21606823 }}</ref> ~ 0.6% incidence in a series of almost 700 [[TURP]] specimens.<ref name=pmid12861057>{{Cite journal  | last1 = Bostwick | first1 = DG. | last2 = Qian | first2 = J. | last3 = Ma | first3 = J. | last4 = Muir | first4 = TE. | title = Mesonephric remnants of the prostate: incidence and histologic spectrum. | journal = Mod Pathol | volume = 16 | issue = 7 | pages = 630-5 | month = Jul | year = 2003 | doi = 10.1097/01.MP.0000074733.10777.78 | PMID = 12861057 }}</ref>
*Can mimic prostate carcinoma.<ref name=pmid19917478>{{Cite journal  | last1 = Yacoub | first1 = M. | last2 = Milin | first2 = S. | last3 = Irani | first3 = J. | last4 = Fromont | first4 = G. | title = Mesonephric remnant hyperplasia: an unusual benign mimicker of prostate cancer. | journal = Ann Diagn Pathol | volume = 13 | issue = 6 | pages = 402-4 | month = Dec | year = 2009 | doi = 10.1016/j.anndiagpath.2009.03.008 | PMID = 19917478 }}</ref>

==Microscopic==
Features:<ref name=pmid21606823/>
*Small glands in a lobular arrangement composed of cuboidal cells with:
**Scant-to-moderate cytoplasm.<ref name=pmid12861057/>
**Small/indistinct nucleoli.

DDx:<ref name=pmid21606823/>
*[[Sclerosing adenosis]] of the prostate gland.
*[[Prostate carcinoma]] - esp. Gleason pattern 5.

===Images===
www:
*[http://www.nature.com/modpathol/journal/v16/n7/fig_tab/3880816f1.html#figure-title Mesonephric remnants (nature.com)].<ref name=pmid12861057/>

==IHC==
Features:<ref name=pmid21606823/>
*PAX8 +ve.
*PSA -ve (all).
*PSAP -ve.<ref name=pmid12861057>{{Cite journal  | last1 = Bostwick | first1 = DG. | last2 = Qian | first2 = J. | last3 = Ma | first3 = J. | last4 = Muir | first4 = TE. | title = Mesonephric remnants of the prostate: incidence and histologic spectrum. | journal = Mod Pathol | volume = 16 | issue = 7 | pages = 630-5 | month = Jul | year = 2003 | doi = 10.1097/01.MP.0000074733.10777.78 | PMID = 12861057 }</ref>
*CK34betaE12 +ve/-ve (diffuse +ve in 4/7 cases)
*p63 -ve.
*AMACR +ve (focal).

==See also==
*[[Prostate gland]].
*[[Prostate cancer]].

==References==
{{Reflist|2}}

[[Category:Prostate gland]]
[[Category:Diagnosis]]