Difference between revisions of "Histiocytoses"
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===IHC=== | ===IHC=== | ||
Langerin (CD207).<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/604862 http://www.ncbi.nlm.nih.gov/omim/604862]. Accessed on: 2 February 2011.</ref> | Langerin (CD207).<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/604862 http://www.ncbi.nlm.nih.gov/omim/604862]. Accessed on: 2 February 2011.</ref> | ||
==Erdheim-Chester disease== | |||
===General=== | |||
*Rare. | |||
===Gross=== | |||
Features: | |||
*Bone involvement - classic. | |||
*Usually multiple systems are involved. | |||
===Microscopic=== | |||
Features:<ref name=pmid15509691>{{Cite journal | last1 = Sheu | first1 = SY. | last2 = Wenzel | first2 = RR. | last3 = Kersting | first3 = C. | last4 = Merten | first4 = R. | last5 = Otterbach | first5 = F. | last6 = Schmid | first6 = KW. | title = Erdheim-Chester disease: case report with multisystemic manifestations including testes, thyroid, and lymph nodes, and a review of literature. | journal = J Clin Pathol | volume = 57 | issue = 11 | pages = 1225-8 | month = Nov | year = 2004 | doi = 10.1136/jcp.2004.018481 | PMID = 15509691 }}</ref> | |||
*Foamy histocytes. | |||
**Large cells with gray, bubbly cytoplasm. | |||
*+/-Touton giant cells - very distinctive - '''classic'''. | |||
**Nuclei around cell periphery. | |||
DDx: | |||
*[[Rosai-Dorfman disease]]. | |||
*[[Langerhans cell histiocytosis]]. | |||
Images: | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1770491/figure/f1/ ECD (nih.gov)]. | |||
===IHC=== | |||
Features:<ref name=pmid17405844>{{Cite journal | last1 = Haroche | first1 = J. | last2 = Amoura | first2 = Z. | last3 = Touraine | first3 = P. | last4 = Seilhean | first4 = D. | last5 = Graef | first5 = C. | last6 = Birmelé | first6 = B. | last7 = Wechsler | first7 = B. | last8 = Cluzel | first8 = P. | last9 = Grenier | first9 = PA. | title = Bilateral adrenal infiltration in Erdheim-Chester disease. Report of seven cases and literature review. | journal = J Clin Endocrinol Metab | volume = 92 | issue = 6 | pages = 2007-12 | month = Jun | year = 2007 | doi = 10.1210/jc.2006-2018 | PMID = 17405844 }} | |||
</ref> | |||
*CD68 +ve. | |||
*S100 -ve/+ve. | |||
*CD1a -ve. | |||
==See also== | ==See also== | ||
Revision as of 14:30, 25 March 2012
Histiocytoses, singular histiocytosis, are a rare set of conditions affecting tissue macrophages.
Histiocytoses in a table
Features of histiocytoses:[1]
| Histologic features | EM features | CD68 | S-100 | CD1a | Image | |
|---|---|---|---|---|---|---|
| Macrophage | epithelioid cells, giant cells | - | + | - | - | Macrophages - CD68 (WC) |
| Erdheim-Chester disease | Touton giant cells | - | + | +/- | - | ECD (upmc.edu) |
| Rosai-Dorfman | Emperipolesis | - | + | + | - | RDD (WC) |
| Langerhans cell histiocytosis (LCH) | Reniform nuclei, eosinophilic cytoplasm |
Birbeck granules | + | + | + | LCH (WC) |
Notes:
- EM = electron microscopy.
Langerhans cell histiocytosis
IHC
Langerin (CD207).[2]
Erdheim-Chester disease
General
- Rare.
Gross
Features:
- Bone involvement - classic.
- Usually multiple systems are involved.
Microscopic
Features:[3]
- Foamy histocytes.
- Large cells with gray, bubbly cytoplasm.
- +/-Touton giant cells - very distinctive - classic.
- Nuclei around cell periphery.
DDx:
Images:
IHC
Features:[4]
- CD68 +ve.
- S100 -ve/+ve.
- CD1a -ve.
See also
References
- ↑ Mills, Stacey E; Carter, Darryl; Greenson, Joel K; Oberman, Harold A; Reuter, Victor E (2004). Sternberg's Diagnostic Surgical Pathology (4th ed.). Lippincott Williams & Wilkins. pp. 479. ISBN 978-0781740517.
- ↑ URL: http://www.ncbi.nlm.nih.gov/omim/604862. Accessed on: 2 February 2011.
- ↑ Sheu, SY.; Wenzel, RR.; Kersting, C.; Merten, R.; Otterbach, F.; Schmid, KW. (Nov 2004). "Erdheim-Chester disease: case report with multisystemic manifestations including testes, thyroid, and lymph nodes, and a review of literature.". J Clin Pathol 57 (11): 1225-8. doi:10.1136/jcp.2004.018481. PMID 15509691.
- ↑ Haroche, J.; Amoura, Z.; Touraine, P.; Seilhean, D.; Graef, C.; Birmelé, B.; Wechsler, B.; Cluzel, P. et al. (Jun 2007). "Bilateral adrenal infiltration in Erdheim-Chester disease. Report of seven cases and literature review.". J Clin Endocrinol Metab 92 (6): 2007-12. doi:10.1210/jc.2006-2018. PMID 17405844.