Difference between revisions of "Histiocytoses"
Jump to navigation
Jump to search
(+ECD) |
(more) |
||
| Line 21: | Line 21: | ||
| [http://en.wikipedia.org/wiki/File:Xanthogranulomatous_pyelonephritis_cd68.jpg Macrophages - CD68 (WC)] | | [http://en.wikipedia.org/wiki/File:Xanthogranulomatous_pyelonephritis_cd68.jpg Macrophages - CD68 (WC)] | ||
|- | |- | ||
| Erdheim-Chester disease | | [[Erdheim-Chester disease]] | ||
| [[Touton giant cells]] | | [[Touton giant cells]] | ||
| - | | - | ||
| Line 49: | Line 49: | ||
==Langerhans cell histiocytosis== | ==Langerhans cell histiocytosis== | ||
{{Main|Langerhans cell histiocytosis}} | |||
===IHC=== | ===IHC=== | ||
Langerin (CD207).<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/604862 http://www.ncbi.nlm.nih.gov/omim/604862]. Accessed on: 2 February 2011.</ref> | Langerin (CD207).<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/604862 http://www.ncbi.nlm.nih.gov/omim/604862]. Accessed on: 2 February 2011.</ref> | ||
==Erdheim-Chester disease== | ==Erdheim-Chester disease== | ||
*Abbreviated ''ECD''. | |||
===General=== | ===General=== | ||
*Rare. | *Rare. | ||
*Non-clonal proliferation of histiocytes.<ref name=pmid12065781>{{Cite journal | last1 = Al-Quran | first1 = S. | last2 = Reith | first2 = J. | last3 = Bradley | first3 = J. | last4 = Rimsza | first4 = L. | title = Erdheim-Chester disease: case report, PCR-based analysis of clonality, and review of literature. | journal = Mod Pathol | volume = 15 | issue = 6 | pages = 666-72 | month = Jun | year = 2002 | doi = 10.1038/modpathol.3880583 | PMID = 12065781 }}</ref> | |||
===Gross=== | ===Gross=== | ||
Revision as of 14:33, 25 March 2012
Histiocytoses, singular histiocytosis, are a rare set of conditions affecting tissue macrophages.
Histiocytoses in a table
Features of histiocytoses:[1]
| Histologic features | EM features | CD68 | S-100 | CD1a | Image | |
|---|---|---|---|---|---|---|
| Macrophage | epithelioid cells, giant cells | - | + | - | - | Macrophages - CD68 (WC) |
| Erdheim-Chester disease | Touton giant cells | - | + | +/- | - | ECD (upmc.edu) |
| Rosai-Dorfman | Emperipolesis | - | + | + | - | RDD (WC) |
| Langerhans cell histiocytosis (LCH) | Reniform nuclei, eosinophilic cytoplasm |
Birbeck granules | + | + | + | LCH (WC) |
Notes:
- EM = electron microscopy.
Langerhans cell histiocytosis
Main article: Langerhans cell histiocytosis
IHC
Langerin (CD207).[2]
Erdheim-Chester disease
- Abbreviated ECD.
General
- Rare.
- Non-clonal proliferation of histiocytes.[3]
Gross
Features:
- Bone involvement - classic.
- Usually multiple systems are involved.
Microscopic
Features:[4]
- Foamy histocytes.
- Large cells with gray, bubbly cytoplasm.
- +/-Touton giant cells - very distinctive - classic.
- Nuclei around cell periphery.
DDx:
Images:
IHC
Features:[5]
- CD68 +ve.
- S100 -ve/+ve.
- CD1a -ve.
See also
References
- ↑ Mills, Stacey E; Carter, Darryl; Greenson, Joel K; Oberman, Harold A; Reuter, Victor E (2004). Sternberg's Diagnostic Surgical Pathology (4th ed.). Lippincott Williams & Wilkins. pp. 479. ISBN 978-0781740517.
- ↑ URL: http://www.ncbi.nlm.nih.gov/omim/604862. Accessed on: 2 February 2011.
- ↑ Al-Quran, S.; Reith, J.; Bradley, J.; Rimsza, L. (Jun 2002). "Erdheim-Chester disease: case report, PCR-based analysis of clonality, and review of literature.". Mod Pathol 15 (6): 666-72. doi:10.1038/modpathol.3880583. PMID 12065781.
- ↑ Sheu, SY.; Wenzel, RR.; Kersting, C.; Merten, R.; Otterbach, F.; Schmid, KW. (Nov 2004). "Erdheim-Chester disease: case report with multisystemic manifestations including testes, thyroid, and lymph nodes, and a review of literature.". J Clin Pathol 57 (11): 1225-8. doi:10.1136/jcp.2004.018481. PMID 15509691.
- ↑ Haroche, J.; Amoura, Z.; Touraine, P.; Seilhean, D.; Graef, C.; Birmelé, B.; Wechsler, B.; Cluzel, P. et al. (Jun 2007). "Bilateral adrenal infiltration in Erdheim-Chester disease. Report of seven cases and literature review.". J Clin Endocrinol Metab 92 (6): 2007-12. doi:10.1210/jc.2006-2018. PMID 17405844.