Difference between revisions of "Zollinger-Ellison syndrome"
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==Microscopic== | ==Microscopic== | ||
===Pancreas=== | |||
:See: ''[[Pancreatic neuroendocrine tumour]]''. | :See: ''[[Pancreatic neuroendocrine tumour]]''. | ||
===Stomach=== | |||
*G-cell hyperplasia. | |||
DDx: | |||
*Pseudo-Zollinger-Ellison syndrome.<ref name=pmid10833904>{{Cite journal | last1 = Tomaszewska | first1 = R. | last2 = Kedra | first2 = B. | last3 = Stachura | first3 = J. | title = Hypertrophic gastritis, primary diffuse G-cell hyperplasia and pancreatic metaplasia of the gastric mucosa (pseudo-Zollinger-Ellison syndrome)--case report. | journal = Pol J Pathol | volume = 51 | issue = 1 | pages = 51-4 | month = | year = 2000 | doi = | PMID = 10833904 }} | |||
</ref> | |||
==See also== | ==See also== | ||
Revision as of 22:29, 29 April 2013
Zollinger-Ellison syndrome, abbreviated ZES, is the triad of pancreatic gastrinoma, peptic ulcers of the small bowel and gastric hypersecretion.[1]
General
- May be part of multiple endocrine neoplasia 1.
Clinical:
- Abdominal pain.
- Diarrhea.
Laboratory:
- Serum gastrin often elevated - though not usually not very high.[2]
Microscopic
Pancreas
Stomach
- G-cell hyperplasia.
DDx:
- Pseudo-Zollinger-Ellison syndrome.[3]
See also
References
- ↑ Zollinger RM, Ellison EH (1955). "Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas". Ann. Surg. 142 (4): 709–23; discussion, 724–8. doi:10.1097/00000658-195510000-00015. PMC 1465210. PMID 13259432. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1465210/.
- ↑ Berna, MJ.; Hoffmann, KM.; Serrano, J.; Gibril, F.; Jensen, RT. (Nov 2006). "Serum gastrin in Zollinger-Ellison syndrome: I. Prospective study of fasting serum gastrin in 309 patients from the National Institutes of Health and comparison with 2229 cases from the literature.". Medicine (Baltimore) 85 (6): 295-330. doi:10.1097/01.md.0000236956.74128.76. PMID 17108778.
- ↑ Tomaszewska, R.; Kedra, B.; Stachura, J. (2000). "Hypertrophic gastritis, primary diffuse G-cell hyperplasia and pancreatic metaplasia of the gastric mucosa (pseudo-Zollinger-Ellison syndrome)--case report.". Pol J Pathol 51 (1): 51-4. PMID 10833904.