Difference between revisions of "Non-small cell lung carcinoma"
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It can be understood as a synonym for ''large cell carcinoma'' which is umbrella term that includes [[squamous cell carcinoma of lung]] and [[adenocarcinoma of the lung]]. | It can be understood as a synonym for ''large cell carcinoma'' which is umbrella term that includes [[squamous cell carcinoma of lung]] and [[adenocarcinoma of the lung]]. | ||
==IHC== | |||
Sloan-Kettering algorithm - Rekhtman ''et al.'':<ref name=pmid21623384>{{Cite journal | last1 = Rekhtman | first1 = N. | last2 = Ang | first2 = DC. | last3 = Sima | first3 = CS. | last4 = Travis | first4 = WD. | last5 = Moreira | first5 = AL. | title = Immunohistochemical algorithm for differentiation of lung adenocarcinoma and squamous cell carcinoma based on large series of whole-tissue sections with validation in small specimens. | journal = Mod Pathol | volume = 24 | issue = 10 | pages = 1348-59 | month = Oct | year = 2011 | doi = 10.1038/modpathol.2011.92 | PMID = 21623384 }}</ref> | |||
{| class="wikitable sortable" | |||
! TTF-1\p63 | |||
! p63 -ve (0% of cells) | |||
! p63 +ve <50% of cells | |||
! p63 +ve >=50% of cells | |||
|- | |||
| TTF-1 +ve >=50% of cells | |||
| Adenocarcinoma | |||
| Adenocarcinoma | |||
| Adenocarcinoma | |||
|- | |||
| TTF-1 +ve <50% of cells | |||
| Adenocarcinoma | |||
| Adenocarcinoma | |||
| Squamous carcinoma | |||
|- | |||
| TTF-1 -ve (0% of cells) | |||
| Adenocarcinoma | |||
| CK5/6 to determine | |||
| Squamous carcinoma | |||
|} | |||
==See also== | ==See also== | ||
*[[Lung tumours]]. | *[[Lung tumours]]. | ||
==References== | |||
{{Reflist|1}} | |||
[[Category:Pulmonary pathology]] | [[Category:Pulmonary pathology]] | ||
Revision as of 00:08, 3 May 2013
Non-small cell lung carcinoma, abbreviated NSCLC, is a malignant epithelial neoplasm that is not small cell carcinoma of the lung.
It can be understood as a synonym for large cell carcinoma which is umbrella term that includes squamous cell carcinoma of lung and adenocarcinoma of the lung.
IHC
Sloan-Kettering algorithm - Rekhtman et al.:[1]
| TTF-1\p63 | p63 -ve (0% of cells) | p63 +ve <50% of cells | p63 +ve >=50% of cells |
|---|---|---|---|
| TTF-1 +ve >=50% of cells | Adenocarcinoma | Adenocarcinoma | Adenocarcinoma |
| TTF-1 +ve <50% of cells | Adenocarcinoma | Adenocarcinoma | Squamous carcinoma |
| TTF-1 -ve (0% of cells) | Adenocarcinoma | CK5/6 to determine | Squamous carcinoma |
See also
References
- ↑ Rekhtman, N.; Ang, DC.; Sima, CS.; Travis, WD.; Moreira, AL. (Oct 2011). "Immunohistochemical algorithm for differentiation of lung adenocarcinoma and squamous cell carcinoma based on large series of whole-tissue sections with validation in small specimens.". Mod Pathol 24 (10): 1348-59. doi:10.1038/modpathol.2011.92. PMID 21623384.