Difference between revisions of "Embryonal carcinoma"
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| Gross = | | Gross = | ||
| Grossing = | | Grossing = | ||
| Site = [[testis]], [[ovary]] | | Site = [[testis]], [[ovary]], [[mediastinum]] | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
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*Affects young adults. | *Affects young adults. | ||
**May be seen in women. | **May be seen in women. | ||
==Gross== | |||
*Typically a [[testis|testicular mass]]. | |||
*May be seen in the [[mediastinum]].<ref name=pmid22877235>PMID 22877235.</ref> | |||
==Microscopic== | ==Microscopic== | ||
Revision as of 07:31, 3 July 2013
| Embryonal carcinoma | |
|---|---|
| Diagnosis in short | |
 Embryonal carcinoma. H&E stain. | |
|
| |
| LM | vesicular nuclei, nuclear overlap, necrosis (common), mitoses, variable architecture (tubulopapillary, glandular, solid, embryoid bodies) |
| LM DDx | seminoma, mixed germ cell tumour, other carcinomas |
| IHC | CD30 +ve, AE1/AE3 +ve |
| Site | testis, ovary, mediastinum |
|
| |
| Signs | testicular mass, pelvic mass |
Embryonal carcinoma is a type of germ cell tumour. It is commonly as a component of mixed germ cell tumours.
General
- Affects young adults.
- May be seen in women.
Gross
- Typically a testicular mass.
- May be seen in the mediastinum.[1]
Microscopic
Features:[2]
- Nucleoli - key feature.
- Vesicular nuclei (clear, empty appearing nuclei) - key feature.
- Nuclei overlap.
- Necrosis - common.
- Not commonly present in seminoma.
- Indistinct cell borders
- Mitoses - common.
- Variable architecture:
- Tubulopapillary.
- Glandular.
- Solid.
- Embryoid bodies - ball of cells in surrounded by empty space on three sides.
Notes:
- Cytoplasmic staining variable (eosinophilic to basophilic).
DDx:
Images
Embryonal carcinoma - very high mag. - cropped (WC/Nephron)
Embryonal carcinoma - high mag. (WC/Nephron)
Embryonal carcinoma - high mag. (WC/Nephron)
Embryonal carcinoma - intermed. mag. (WC/Nephron)
Embryonal carcinoma - low mag. (WC/Nephron)
IHC
- AE1/AE3 +ve.
- CD30 +ve.
See also
References
- ↑ PMID 22877235.
- ↑ Zhou, Ming; Magi-Galluzzi, Cristina (2006). Genitourinary Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 549. ISBN 978-0443066771.