Difference between revisions of "Keratoacanthoma"

From Libre Pathology
Jump to navigation Jump to search
(+cat.)
(split-out into separate article)
Line 1: Line 1:
#redirect [[Dermatologic neoplasms#Keratoacanthoma]]
'''Keratoacanthoma''' is clinically worrisome lesion that classically arise on the nose.
It is abbreviated '''KA'''.
 
==General==
*Generally considered to be benign.
**Rare reports of [[metastases]] suggesting it may be a form of [[squamous cell carcinoma]].<ref>{{cite journal |author=Mandrell JC, Santa Cruz D |title=Keratoacanthoma: hyperplasia, benign neoplasm, or a type of squamous cell carcinoma? |journal=Semin Diagn Pathol |volume=26 |issue=3 |pages=150–63 |year=2009 |month=August |pmid=20043514 |doi= |url=}}</ref>
 
===Clinical===
*May grow rapidly (weeks or months) then involute.
*Main DDx is [[squamous cell carcinoma]].
*Exophytic lesion, well-circumscribed.
 
==Microscopic==
Features:<ref name=Ref_Klatt378>{{Ref Klatt|378}}</ref>
*Expansion of stratum spinosum - pushing [[tongue]]-like downward growth of epidermis into the dermis.
*Keratin collection ("keratin plug") at the center of lesion-superficial aspect.
*Cells have glassy pink cytoplasm.
*Minimal/no nuclear atypia.
 
Note:
*Classically described as a "volcano lesion" with pale pink cells.
*May have features of regression - [[PMN]]s, fibrosis (???).
 
DDx:<ref name=Ref_Derm379>{{Ref Derm|379}}</ref>
*[[Verruca vulgaris]].
*Conventional [[squamous cell carcinoma of the skin]] with a cup-shape.
*[[Pseudoepitheliomatous hyperplasia]].
 
===Image===
<gallery>
Image:Skin_keratoacanthoma_whole_slide.jpg | Keratoacanthoma. (WC)
</gallery>
 
==See also==
*[[Dermatologic neoplasms]].
*[[Dermatopathology]].
 
==References==
{{Reflist|1}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]

Revision as of 11:40, 4 July 2013

Keratoacanthoma is clinically worrisome lesion that classically arise on the nose. It is abbreviated KA.

General

Clinical

  • May grow rapidly (weeks or months) then involute.
  • Main DDx is squamous cell carcinoma.
  • Exophytic lesion, well-circumscribed.

Microscopic

Features:[2]

  • Expansion of stratum spinosum - pushing tongue-like downward growth of epidermis into the dermis.
  • Keratin collection ("keratin plug") at the center of lesion-superficial aspect.
  • Cells have glassy pink cytoplasm.
  • Minimal/no nuclear atypia.

Note:

  • Classically described as a "volcano lesion" with pale pink cells.
  • May have features of regression - PMNs, fibrosis (???).

DDx:[3]

Image

See also

References

  1. Mandrell JC, Santa Cruz D (August 2009). "Keratoacanthoma: hyperplasia, benign neoplasm, or a type of squamous cell carcinoma?". Semin Diagn Pathol 26 (3): 150–63. PMID 20043514.
  2. Klatt, Edward C. (2006). Robbins and Cotran Atlas of Pathology (1st ed.). Saunders. pp. 378. ISBN 978-1416002741.
  3. Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 379. ISBN 978-0443066542.