Difference between revisions of "Keloid"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Keloid_-_add_-_intermed_mag.jpg | |||
| Width = | |||
| Caption = Keloid. [[H&E stain]]. | |||
| Micro = thick collagen bundles - surrounded by paler staining fibroblasts, loss of adnexal structures | |||
| Subtypes = | |||
| LMDDx = hypertrophic scar | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[skin]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = typically dark skinned individuals | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
}} | |||
:''Hypertrophic scar'' redirects here. | |||
'''Keloid''' is an uncommon abnormal [[scar|scarring]]. | |||
==General== | |||
*Sites of previous trauma/surgery, esp. in dark skinned individuals.<ref name=Ref_WMSP492>{{Ref WMSP|492}}</ref> | |||
Note: | |||
*'''Reported as "keloidal-type collagen"'''; the clinician decides between ''hypertrophic scar'' and ''keloid''. | |||
==Microscopic== | |||
Features:<ref name=Ref_WMSP492>{{Ref WMSP|492}}</ref> | |||
*Thick collagen bundles - surrounded by paler staining fibroblasts - '''key feature'''. | |||
*Lesion replaces adnexal structures, e.g. hair, sweat glands. | |||
DDx: | |||
*Hypertrophic scar.<ref name=pmid20927486>{{Cite journal | last1 = Gauglitz | first1 = GG. | last2 = Korting | first2 = HC. | last3 = Pavicic | first3 = T. | last4 = Ruzicka | first4 = T. | last5 = Jeschke | first5 = MG. | title = Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies. | journal = Mol Med | volume = 17 | issue = 1-2 | pages = 113-25 | month = | year = | doi = 10.2119/molmed.2009.00153 | PMID = 20927486 | PMC = 3022978 }}</ref> | |||
===Images=== | |||
<gallery> | |||
Image:Keloid_-_add_-_low_mag.jpg | Keloid - low mag. (WC/Nephron) | |||
Image:Keloid_-_add_-_intermed_mag.jpg | Keloid - intermed. mag. (WC/Nephron) | |||
Image:Keloid_-_high_mag.jpg | Keloid - high mag. (WC/Nephron) | |||
</gallery> | |||
www: | |||
*[http://missinglink.ucsf.edu/lm/DermatologyGlossary/keloids.html Keloid (ucsf.edu)]. | |||
==Sign out== | |||
<pre> | |||
SKIN LESION, LEFT SCAPULA, EXCISION: | |||
- DERMAL SCAR WITH KELOIDAL-TYPE COLLAGEN, SEE COMMENT. | |||
COMMENT: | |||
The findings are consistent with a hypertrophic scar or keloid; clinical correlation is required. | |||
</pre> | |||
===Clinical provided=== | |||
<pre> | |||
SKIN LESION, LEFT NIPPLE AREOLA, EXCISION: | |||
- DERMAL SCAR WITH KELOIDAL-TYPE COLLAGEN, CONSISTENT WITH HYPERTROPHIC SCAR. | |||
</pre> | |||
==See also== | |||
*[[Non-malignant skin disease]]. | |||
==References== | |||
{{Reflist|1} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Dermatopathology]] | |||
Revision as of 22:28, 21 August 2013
| Keloid | |
|---|---|
| Diagnosis in short | |
 Keloid. H&E stain. | |
|
| |
| LM | thick collagen bundles - surrounded by paler staining fibroblasts, loss of adnexal structures |
| LM DDx | hypertrophic scar |
| Site | skin |
|
| |
| Clinical history | typically dark skinned individuals |
| Prognosis | benign |
- Hypertrophic scar redirects here.
Keloid is an uncommon abnormal scarring.
General
- Sites of previous trauma/surgery, esp. in dark skinned individuals.[1]
Note:
- Reported as "keloidal-type collagen"; the clinician decides between hypertrophic scar and keloid.
Microscopic
Features:[1]
- Thick collagen bundles - surrounded by paler staining fibroblasts - key feature.
- Lesion replaces adnexal structures, e.g. hair, sweat glands.
DDx:
- Hypertrophic scar.[2]
Images
Keloid - low mag. (WC/Nephron)
Keloid - intermed. mag. (WC/Nephron)
Keloid - high mag. (WC/Nephron)
www:
Sign out
SKIN LESION, LEFT SCAPULA, EXCISION: - DERMAL SCAR WITH KELOIDAL-TYPE COLLAGEN, SEE COMMENT. COMMENT: The findings are consistent with a hypertrophic scar or keloid; clinical correlation is required.
Clinical provided
SKIN LESION, LEFT NIPPLE AREOLA, EXCISION: - DERMAL SCAR WITH KELOIDAL-TYPE COLLAGEN, CONSISTENT WITH HYPERTROPHIC SCAR.
See also
References
{{Reflist|1}
- ↑ 1.0 1.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 492. ISBN 978-0781765275.
- ↑ Gauglitz, GG.; Korting, HC.; Pavicic, T.; Ruzicka, T.; Jeschke, MG.. "Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies.". Mol Med 17 (1-2): 113-25. doi:10.2119/molmed.2009.00153. PMC 3022978. PMID 20927486. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022978/.