Difference between revisions of "Invasive lobular carcinoma"

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#redirect [[Invasive_breast_cancer#Invasive_lobular_carcinoma]]
'''Invasive lobular carcinoma''', abbreviated '''ILC''', is the second most common form of [[Invasive breast cancer]].


It may be referred to as '''lobular carcinoma'''; however, this may lead to confusion with [[lobular carcinoma in situ]].
==General==
*May be associated with a CDH1 mutation - seen in diffuse type [[stomach|gastric]] cancer.<ref>URL: [http://www.asco.org/ascov2/Meetings/Abstracts?&vmview=abst_detail_view&confID=65&abstractID=33006 http://www.asco.org/ascov2/Meetings/Abstracts?&vmview=abst_detail_view&confID=65&abstractID=33006]. Accessed on: 19 April 2011.</ref><ref name=omim192090>{{OMIM|192090}}</ref>
==Microscopic==
Features:
*"Single file" - cell line-up in a row.
**Cell should not be cohesive -- [[lymphoma]] should briefly come to mind.
***primary lymphoma of the breast exists... but it is extremely rare.
*NO gland formation.
**If it forms glands... it is more likely NST.
*May have [[signet ring cell|signet ring]] morphology.
*NO [[desmoplastic reaction]], i.e. the stroma surrounding the tumour cells should look benign and undisturbed.
Note:
*Commonly have low grade nuclear features.
===Images===
<gallery>
Image:Lobular_carcinoma_-_low_mag.jpg | Lobular carcinoma - low mag. (WC/Nephron)
Image:Lobular_carcinoma_-_high_mag.jpg | Lobular carcinoma - high mag. (WC/Nephron)
Image:Lobular_carcinoma_-_high_mag.jpg | Lobular carcinoma - very high mag. (WC/Nephron)
</gallery>
More [[WC]] images:
*[http://commons.wikimedia.org/wiki/File:Breast_invasive_lobular_carcinoma_%281%29.jpg Lobular carcinoma - 1 (WC)].
*[http://commons.wikimedia.org/wiki/File:Breast_invasive_lobular_carcinoma_%282%29.jpg Lobular carcinoma - 2 (WC)].
===Subclassification===
*Classic lobular carcinoma.
**Low nuclear grade - NO significant variation of nucleus size.
*Pleomorphic lobular carcinoma.
**Significant nuclear atypia.
Note:
*Some pathologist grade lobular carcinoma like other types and avoid the term "pleomorphic lobular carcinoma."<ref>MUA. Jan 22, 2009.</ref>
==See also==
*[[Invasive breast cancer]].
==References==
{{Reflist|2}}
[[Category:Invasive breast cancer]]
[[Category:Diagnosis]]
[[Category:Diagnosis]]

Revision as of 10:39, 14 February 2014

Invasive lobular carcinoma, abbreviated ILC, is the second most common form of Invasive breast cancer.

It may be referred to as lobular carcinoma; however, this may lead to confusion with lobular carcinoma in situ.

General

  • May be associated with a CDH1 mutation - seen in diffuse type gastric cancer.[1][2]

Microscopic

Features:

  • "Single file" - cell line-up in a row.
    • Cell should not be cohesive -- lymphoma should briefly come to mind.
      • primary lymphoma of the breast exists... but it is extremely rare.
  • NO gland formation.
    • If it forms glands... it is more likely NST.
  • May have signet ring morphology.
  • NO desmoplastic reaction, i.e. the stroma surrounding the tumour cells should look benign and undisturbed.

Note:

  • Commonly have low grade nuclear features.

Images

  • Lobular carcinoma - low mag. (WC/Nephron)

  • Lobular carcinoma - high mag. (WC/Nephron)

  • Lobular carcinoma - very high mag. (WC/Nephron)

More WC images:

Subclassification

  • Classic lobular carcinoma.
    • Low nuclear grade - NO significant variation of nucleus size.
  • Pleomorphic lobular carcinoma.
    • Significant nuclear atypia.

Note:

  • Some pathologist grade lobular carcinoma like other types and avoid the term "pleomorphic lobular carcinoma."[3]

See also

References

  1. ↑ URL: http://www.asco.org/ascov2/Meetings/Abstracts?&vmview=abst_detail_view&confID=65&abstractID=33006. Accessed on: 19 April 2011.
  2. ↑ Online 'Mendelian Inheritance in Man' (OMIM) 192090
  3. ↑ MUA. Jan 22, 2009.
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