Difference between revisions of "Splenic hamartoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Splenic_hamartoma_-_very_low_mag.jpg | |||
| Width = | |||
| Caption = Splenic hamartoma. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = variable size irregular vascular channels, red pulp-like disorganized stroma, +/-lymphoid follicles | |||
| Subtypes = | |||
| LMDDx = [[littoral cell angioma]] | |||
| Stains = | |||
| IHC = factor VIII +ve, CD31 -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = red, well-circumscribed | |||
| Grossing = | |||
| Site = [[spleen]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = +/-splenic enlargement | |||
| Symptoms = +/-abdominal pain | |||
| Prevalence = | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
| Tx = observe or splenectomy | |||
}} | |||
'''Splenic hamartoma''', also '''[[hamartoma]] of the spleen''', is an uncommon benign lesion of the [[spleen]]. | '''Splenic hamartoma''', also '''[[hamartoma]] of the spleen''', is an uncommon benign lesion of the [[spleen]]. | ||
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Image:Spleen_hamartom.jpg | Splenic hamartoma. (WC) | Image:Spleen_hamartom.jpg | Splenic hamartoma. (WC) | ||
</gallery> | </gallery> | ||
==Microscopic== | ==Microscopic== | ||
Features:<ref name=pmid19123729/> | Features:<ref name=pmid19123729/> | ||
| Line 19: | Line 51: | ||
*Red pulp-like disorganized stroma | *Red pulp-like disorganized stroma | ||
*+/-Lymphoid follicles. | *+/-Lymphoid follicles. | ||
DDx: | |||
*[[Littoral cell angioma]]. | |||
===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||
Image: | Image: Splenic hamartoma - very low mag.jpg | Splenic hamartoma - very low mag. (WC) | ||
Image: | Image: Splenic hamartoma - low mag.jpg | Splenic hamartoma - low mag. (WC) | ||
Image: | Image: Splenic hamartoma - intermed mag.jpg | Splenic hamartoma - intermed. mag. (WC) | ||
Image: Splenic hamartoma - add - intermed mag.jpg | Splenic hamartoma - intermed. mag. (WC) | |||
Image: Splenic hamartoma - high mag.jpg | Splenic hamartoma - high mag. (WC) | |||
Image: Splenic hamartoma - very high mag.jpg | Splenic hamartoma - very high mag. (WC) | |||
</gallery> | </gallery> | ||
Latest revision as of 02:03, 9 April 2014
| Splenic hamartoma | |
|---|---|
| Diagnosis in short | |
 Splenic hamartoma. H&E stain. | |
|
| |
| LM | variable size irregular vascular channels, red pulp-like disorganized stroma, +/-lymphoid follicles |
| LM DDx | littoral cell angioma |
| IHC | factor VIII +ve, CD31 -ve |
| Gross | red, well-circumscribed |
| Site | spleen |
|
| |
| Signs | +/-splenic enlargement |
| Symptoms | +/-abdominal pain |
| Prognosis | benign |
| Treatment | observe or splenectomy |
Splenic hamartoma, also hamartoma of the spleen, is an uncommon benign lesion of the spleen.
General
Gross
- Red lesion.
- Well-circumscribed.
Image
Splenic hamartoma. (WC)
Microscopic
Features:[3]
- Variable size irregular vascular channels
- Red pulp-like disorganized stroma
- +/-Lymphoid follicles.
DDx:
Images
Splenic hamartoma - very low mag. (WC)
Splenic hamartoma - low mag. (WC)
Splenic hamartoma - intermed. mag. (WC)
Splenic hamartoma - intermed. mag. (WC)
Splenic hamartoma - high mag. (WC)
Splenic hamartoma - very high mag. (WC)
IHC
Features:
- CD8 +ve endothelial cells.[3]
- Factor VIII +ve (diffuse intense).[4]
- Background spleen -ve.
- CD31 -ve.[4]
- Background spleen +ve.
See also
References
- ↑ Sankar, S.; Thanka, J.; Jagdishchandrabose, S.; Rajendran, S.. "Splenic hamartoma: a rare vascular space occupying lesion of the spleen.". Indian J Pathol Microbiol 54 (1): 223-5. doi:10.4103/0377-4929.77416. PMID 21393931.
- ↑ Tatekawa, Y.; Kanehiro, H.; Nakajima, Y. (Sep 2007). "Laparoscopic extirpation of splenic hamartoma.". Pediatr Surg Int 23 (9): 911-4. doi:10.1007/s00383-007-1902-1. PMID 17364201.
- ↑ 3.0 3.1 Lee, H.; Maeda, K. (Jan 2009). "Hamartoma of the spleen.". Arch Pathol Lab Med 133 (1): 147-51. doi:10.1043/1543-2165-133.1.147. PMID 19123729.
- ↑ 4.0 4.1 Ali, TZ.; Beyer, G.; Taylor, M.; Volpe, C.; Papadimitriou, JC. (Jan 2005). "Splenic hamartoma: immunohistochemical and ultrastructural profile of two cases.". Int J Surg Pathol 13 (1): 103-11. PMID 15735864.