Difference between revisions of "Mesonephric duct remnant"

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#redirect [[Gynecologic_pathology#Mesonephric_duct_remnant]]
'''Mesonephric duct remnant''', also '''Wolffian duct remnant''' and  '''Gartner duct''', a benign embryological remanant that is usually ignored.
 
==General==
Epidemiology:
*Embryological remnant - benign.
**Wolffian duct = precursor of male reproductive tract.<ref name=pmid16567946>{{cite journal |author=Hannema SE, Print CG, Charnock-Jones DS, Coleman N, Hughes IA |title=Changes in gene expression during Wolffian duct development |journal=Horm. Res. |volume=65 |issue=4 |pages=200–9 |year=2006 |pmid=16567946 |doi=10.1159/000092408 |url=}}</ref>
 
Notes:
*This is ''not'' a finding that is reported.  The importance of this finding is knowing it isn't something neoplastic.
*Lame way of remember the synonyms ''Gartner, Mesonephric, and Wolffian'': ''GMW''... it is trying to be a ''BMW'' but in ''g''irls.
 
==Gross==
*Classically anterior-lateral wall of the [[vagina]].<ref name=Ref_GP97>{{Ref GP|97}}</ref>
 
Note:
*Same location as Muellerian cyst.
==Microscopic==
Features:<ref>Sternberg SE. Histology for Pathologists. 2nd Ed. P.893.</ref>
*Small duct -- typically ~50-100 micrometres in diameter.
**Duct lined by cuboidal cells with moderate eosinophilic cytoplasm.
DDx:
*Muellerian cyst - most common vaginal cyst.<ref name=Ref_GP97>{{Ref GP|97}}</ref>
*[[Vaginal inclusion cyst]].
*[[Cervical adenocarcinoma]], not otherwise specified.
*[[Minimal deviation adenocarcinoma of the uterine cervix]].
*[[Mesonephric adenocarcinoma]] - has cellular atypia.
*[[Wolffian duct hyperplasia]].
 
Images:
*[http://www.webpathology.com/image.asp?case=550&n=1 Mesonephric duct remnant - low mag. (webpathology.com)].
*[http://www.webpathology.com/image.asp?n=2&Case=550 Mesonephric duct remnant - high mag. (webpathology.com)].
 
==IHC==
Features:<ref name=Ref_WMSP442>{{Ref WMSP|442}}</ref>
*CD10 +ve.
*CK7 +ve.
*PAX2 +ve (nuclear - strong & diffuse).<ref name=pmid20061933>{{Cite journal  | last1 = Rabban | first1 = JT. | last2 = McAlhany | first2 = S. | last3 = Lerwill | first3 = MF. | last4 = Grenert | first4 = JP. | last5 = Zaloudek | first5 = CJ. | title = PAX2 distinguishes benign mesonephric and mullerian glandular lesions of the cervix from endocervical adenocarcinoma, including minimal deviation adenocarcinoma. | journal = Am J Surg Pathol | volume = 34 | issue = 2 | pages = 137-46 | month = Feb | year = 2010 | doi = 10.1097/PAS.0b013e3181c89c98 | PMID = 20061933 }}</ref>
**Cancers often lose staining.
 
==See also==
*[[Gynecologic pathology]].
 
==References==
{{Reflist|2}}
 
[[Category:Gynecologic pathology]]

Revision as of 01:07, 19 April 2014

Mesonephric duct remnant, also Wolffian duct remnant and Gartner duct, a benign embryological remanant that is usually ignored.

General

Epidemiology:

  • Embryological remnant - benign.
    • Wolffian duct = precursor of male reproductive tract.[1]

Notes:

  • This is not a finding that is reported. The importance of this finding is knowing it isn't something neoplastic.
  • Lame way of remember the synonyms Gartner, Mesonephric, and Wolffian: GMW... it is trying to be a BMW but in girls.

Gross

  • Classically anterior-lateral wall of the vagina.[2]

Note:

  • Same location as Muellerian cyst.

Microscopic

Features:[3]

  • Small duct -- typically ~50-100 micrometres in diameter.
    • Duct lined by cuboidal cells with moderate eosinophilic cytoplasm.

DDx:

Images:

IHC

Features:[4]

  • CD10 +ve.
  • CK7 +ve.
  • PAX2 +ve (nuclear - strong & diffuse).[5]
    • Cancers often lose staining.

See also

References

  1. ↑ Hannema SE, Print CG, Charnock-Jones DS, Coleman N, Hughes IA (2006). "Changes in gene expression during Wolffian duct development". Horm. Res. 65 (4): 200–9. doi:10.1159/000092408. PMID 16567946.
  2. ↑ 2.0 2.1 Nucci, Marisa R.; Oliva, Esther (2009). Gynecologic Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 97. ISBN 978-0443069208.
  3. ↑ Sternberg SE. Histology for Pathologists. 2nd Ed. P.893.
  4. ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 442. ISBN 978-0781765275.
  5. ↑ Rabban, JT.; McAlhany, S.; Lerwill, MF.; Grenert, JP.; Zaloudek, CJ. (Feb 2010). "PAX2 distinguishes benign mesonephric and mullerian glandular lesions of the cervix from endocervical adenocarcinoma, including minimal deviation adenocarcinoma.". Am J Surg Pathol 34 (2): 137-46. doi:10.1097/PAS.0b013e3181c89c98. PMID 20061933.
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