Difference between revisions of "Eccrine spiradenoma"

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Eccrine_spiradenoma_-_very_low_mag.jpg
| Width      =
| Caption    = Eccrine spiradenoma. [[H&E stain]].
| Synonyms  = spiradenoma
| Micro      = dense nests of cells in the dermis ("dermal blue balls"), mixed cell population (epithelial, myoepithelial, +/-lymphocytes)
| Subtypes  =
| LMDDx      = [[dermal cylindroma]], [[trichoepithelioma]]
| Stains    =
| IHC        = S100 +ve, CK7 +ve, CK18 +ve
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[skin]]
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  = pain - see ''[[painful skin lesions]]''
| Prevalence = uncommon
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign
| Other      = may be related to [[dermal cylindroma]]
| ClinDDx    = [[painful skin lesions]], others
| Tx        = excision
}}
'''Eccrine spiradenoma''', also '''spiradenoma''',<ref>URL: [http://emedicine.medscape.com/article/1062079-overview http://emedicine.medscape.com/article/1062079-overview]. Accessed on: 9 May 2011.</ref> is (usually) a benign, painful skin thingy.  There is case series of malignant ones.<ref name=pmid20851376>{{Cite journal  | last1 = Andreoli | first1 = MT. | last2 = Itani | first2 = KM. | title = Malignant eccrine spiradenoma: a meta-analysis of reported cases. | journal = Am J Surg | volume = 201 | issue = 5 | pages = 688-92 | month = May | year = 2011 | doi = 10.1016/j.amjsurg.2010.04.015 | PMID = 20851376 }}</ref>
'''Eccrine spiradenoma''', also '''spiradenoma''',<ref>URL: [http://emedicine.medscape.com/article/1062079-overview http://emedicine.medscape.com/article/1062079-overview]. Accessed on: 9 May 2011.</ref> is (usually) a benign, painful skin thingy.  There is case series of malignant ones.<ref name=pmid20851376>{{Cite journal  | last1 = Andreoli | first1 = MT. | last2 = Itani | first2 = KM. | title = Malignant eccrine spiradenoma: a meta-analysis of reported cases. | journal = Am J Surg | volume = 201 | issue = 5 | pages = 688-92 | month = May | year = 2011 | doi = 10.1016/j.amjsurg.2010.04.015 | PMID = 20851376 }}</ref>


==General==
==General==
*A painful skin lesion.
*A [[painful skin lesion]].
*Benign.
*Benign.


Line 17: Line 48:
*[[Trichoepithelioma]].
*[[Trichoepithelioma]].


Images:
===Images===
*[http://commons.wikimedia.org/wiki/File:Eccrine_spiradenoma_-_very_low_mag.jpg Eccrine spiradenoma - very low mag. (WC)].
<gallery>
*[http://commons.wikimedia.org/wiki/File:Eccrine_spiradenoma_-_very_high_mag.jpg Eccrine spiradenoma - very high mag. (WC)].
Image:Eccrine_spiradenoma_-_very_low_mag.jpg | Eccrine spiradenoma - very low mag. (WC)
Image:Eccrine_spiradenoma_-_low_mag.jpg | Eccrine spiradenoma - low mag. (WC)
Image:Eccrine_spiradenoma_-_intermed_mag.jpg | Eccrine spiradenoma - intermed. mag. (WC)
Image:Eccrine_spiradenoma_-_high_mag.jpg | Eccrine spiradenoma - high mag. (WC)
Image:Eccrine_spiradenoma_-_very_high_mag.jpg | Eccrine spiradenoma - very high mag. (WC)
</gallery>
www:
*[http://dermimages.med.jhmi.edu/images/spiradenoma_2_060109.jpg Eccrine spiradenoma (dermimages.med.jhmi.edu)].<ref name=dermatlas>URL: [http://www.dermatlas.com/derm/IndexDisplay.cfm?ImageID=-1193575448 http://www.dermatlas.com/derm/IndexDisplay.cfm?ImageID=-1193575448]. Accessed on: 29 November 2010.</ref>
*[http://dermimages.med.jhmi.edu/images/spiradenoma_2_060109.jpg Eccrine spiradenoma (dermimages.med.jhmi.edu)].<ref name=dermatlas>URL: [http://www.dermatlas.com/derm/IndexDisplay.cfm?ImageID=-1193575448 http://www.dermatlas.com/derm/IndexDisplay.cfm?ImageID=-1193575448]. Accessed on: 29 November 2010.</ref>


Revision as of 03:09, 28 May 2014

Eccrine spiradenoma
Diagnosis in short

Eccrine spiradenoma. H&E stain.
Synonyms spiradenoma
LM dense nests of cells in the dermis ("dermal blue balls"), mixed cell population (epithelial, myoepithelial, +/-lymphocytes)
LM DDx dermal cylindroma, trichoepithelioma
IHC S100 +ve, CK7 +ve, CK18 +ve
Site skin
Symptoms pain - see painful skin lesions
Prevalence uncommon
Prognosis benign
Other may be related to dermal cylindroma
Clin. DDx painful skin lesions, others
Treatment excision

Eccrine spiradenoma, also spiradenoma,[1] is (usually) a benign, painful skin thingy. There is case series of malignant ones.[2]

General

Microscopic

Features:[3][4]

  • Dense nests of cells in the dermis; "dermal blue balls".
  • Mixed cell population:
    • Epithelial.
    • Myoepithelial.
  • +/-Lymphocytes.

DDx:

Images

  • Eccrine spiradenoma - very low mag. (WC)

  • Eccrine spiradenoma - low mag. (WC)

  • Eccrine spiradenoma - intermed. mag. (WC)

  • Eccrine spiradenoma - high mag. (WC)

  • Eccrine spiradenoma - very high mag. (WC)

www:

IHC

Features:[5]

  • S100 +ve.
  • Keratins 7, 8, and 18 +ve.

Notes:

  • IHC profile essentially identical to dermal cylindroma.[5]

See also

References

  1. ↑ URL: http://emedicine.medscape.com/article/1062079-overview. Accessed on: 9 May 2011.
  2. ↑ Andreoli, MT.; Itani, KM. (May 2011). "Malignant eccrine spiradenoma: a meta-analysis of reported cases.". Am J Surg 201 (5): 688-92. doi:10.1016/j.amjsurg.2010.04.015. PMID 20851376.
  3. ↑ 3.0 3.1 URL: http://www.dermatlas.com/derm/IndexDisplay.cfm?ImageID=-1193575448. Accessed on: 29 November 2010.
  4. ↑ URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970191-7. Accessed on: 10 May 2011.
  5. ↑ 5.0 5.1 Meybehm, M.; Fischer, HP. (Apr 1997). "Spiradenoma and dermal cylindroma: comparative immunohistochemical analysis and histogenetic considerations.". Am J Dermatopathol 19 (2): 154-61. PMID 9129700.
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