Difference between revisions of "Pityriasis rubra pilaris"
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| Line 5: | Line 5: | ||
| Caption = | | Caption = | ||
| Synonyms = | | Synonyms = | ||
| Micro = | | Micro = alterating [[orthokeratosis]] and [[parakeratosis]] (known as "checkerboard pattern"), +/-eosinophils (common), follicular plugging, [[acantholysis]] (common) | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = | | LMDDx = [[fungal infection]] | ||
| Stains = | | Stains = PASD -ve (to r/o fungal infections) | ||
| IHC = | | IHC = | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
| IF = | | IF = | ||
| Gross = | | Gross = salmon-coloured plaques, well-demarcated | ||
| Grossing = | | Grossing = | ||
| Site = [[skin]] - see ''[[inflammatory skin disorders]]'' | | Site = [[skin]] - see ''[[inflammatory skin disorders]]'' | ||
| Line 28: | Line 28: | ||
| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = | ||
| Tx = | | Tx = retinoids, methotrexate and others | ||
}} | }} | ||
'''Pityriasis rubra pilaris''', abbreviated '''PRP''', is an uncommon [[inflammatory skin disorder]]. | '''Pityriasis rubra pilaris''', abbreviated '''PRP''', is an uncommon [[inflammatory skin disorder]]. | ||
Revision as of 06:20, 24 September 2014
| Pityriasis rubra pilaris | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | alterating orthokeratosis and parakeratosis (known as "checkerboard pattern"), +/-eosinophils (common), follicular plugging, acantholysis (common) |
| LM DDx | fungal infection |
| Stains | PASD -ve (to r/o fungal infections) |
| Gross | salmon-coloured plaques, well-demarcated |
| Site | skin - see inflammatory skin disorders |
|
| |
| Prevalence | uncommon |
| Treatment | retinoids, methotrexate and others |
Pityriasis rubra pilaris, abbreviated PRP, is an uncommon inflammatory skin disorder.
General
- Uncommon.[1]
- Typically sporadic, may be familial.[2]
- Bimodal age distribution:[3]
- Children: <10 years.
- Adults: 40s and 50s.
Treatment:
- Retinoids, methotrexate and others.[3]
Gross
Microscopic
Features:[1]
- Alterating orthokeratosis and parakeratosis - known as "checkerboard pattern".
- +/-Eosinophils (common).
- Follicular plugging.
- Acantholysis.[4]
Images
Stains
IHC
Molecular
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See also
References
- ↑ 1.0 1.1 Marrouche, N.; Kurban, M.; Kibbi, AG.; Abbas, O. (Apr 2014). "Pityriasis rubra pilaris: clinicopathological study of 32 cases from Lebanon.". Int J Dermatol 53 (4): 434-9. PMID 24783259.
- ↑ Mercer, JM.; Pushpanthan, C.; Anandakrishnan, C.; Landells, ID.. "Familial pityriasis rubra pilaris: case report and review.". J Cutan Med Surg 17 (4): 226-32. PMID 23815954.
- ↑ 3.0 3.1 3.2 Klein, A.; Landthaler, M.; Karrer, S. (2010). "Pityriasis rubra pilaris: a review of diagnosis and treatment.". Am J Clin Dermatol 11 (3): 157-70. doi:10.2165/11530070-000000000-00000. PMID 20184391.
- ↑ 4.0 4.1 4.2 Leger, M.; Newlove, T.; Robinson, M.; Patel, R.; Meehan, S.; Ramachandran, S. (Dec 2012). "Pityriasis rubra pilaris.". Dermatol Online J 18 (12): 14. PMID 23286804.