Difference between revisions of "Secretory carcinoma of the salivary gland"
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*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370021/figure/Fig1/ MASC (nih.gov)].<ref name=pmid22127547/> | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370021/figure/Fig2/ MASC (nih.gov)].<ref name=pmid22127547/> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370021/figure/Fig2/ MASC (nih.gov)].<ref name=pmid22127547/> | ||
Revision as of 20:13, 18 March 2015
Mammary analogue secretory carcinoma, abbreviated MASC, is a newly described malignant salivary gland tumour.[1]
General
- Microscopic appearance similar to secretory breast carcinoma.[2]
- Super rare - 21 cases in the world literature as of 2012.[1]
- Original paper described it only in adults.[2]
- Has been described in a pediatric patient.[3]
Gross
- Usually parotid gland.[2]
- Well-circumscribed.[citation needed]
Microscopic
Features:
- Large cells with abundant cytoplasm.
- Small nuclei.
- +/-Lymphocytic infiltrate.
- Solid and microcystic growth pattern.
DDx:
- Acinic cell carcinoma - very closely mimics.
- Abundant basophilic granular cytoplasm.[1]
- Mucoepidermoid carcinoma.
Images
Stains
Features:[2]
- PAS stain +ve.
- Mucicarmine stain +ve.
IHC
Features:[2]
- S-100 +ve.[1]
- Mammomglobin +ve.
- Vimentin +ve.
Molecular
- t(12;15)(p13;q25).
- Fusion of the genes ETV6 and NTRK3.[1]
Note:
- The translocation seen in secretory breast carcinoma and congenital-infantile fibrosarcoma.
See also
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Lei, Y.; Chiosea, SI. (Jun 2012). "Re-evaluating historic cohort of salivary acinic cell carcinoma with new diagnostic tools.". Head Neck Pathol 6 (2): 166-70. doi:10.1007/s12105-011-0312-9. PMID 22127547.
- ↑ 2.0 2.1 2.2 2.3 2.4 Skálová, A.; Vanecek, T.; Sima, R.; Laco, J.; Weinreb, I.; Perez-Ordonez, B.; Starek, I.; Geierova, M. et al. (May 2010). "Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity.". Am J Surg Pathol 34 (5): 599-608. doi:10.1097/PAS.0b013e3181d9efcc. PMID 20410810.
- ↑ Rastatter, JC.; Jatana, KR.; Jennings, LJ.; Melin-Aldana, H. (Mar 2012). "Mammary analogue secretory carcinoma of the parotid gland in a pediatric patient.". Otolaryngol Head Neck Surg 146 (3): 514-5. doi:10.1177/0194599811419044. PMID 21873597.