Difference between revisions of "Renal hybrid oncocytic/chromophobe tumour"
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==General== | ==General== | ||
*Rare. | *Rare. | ||
*Molecular heterogeneous group<ref name=pmid23740406/> - may represent several different entities. | |||
May be seen in several contexts:<ref name=pmid23740406/> | May be seen in several contexts:<ref name=pmid23740406/> | ||
| Line 8: | Line 9: | ||
*[[Birt–Hogg–Dubé syndrome]]. | *[[Birt–Hogg–Dubé syndrome]]. | ||
*Renal oncocytosis. | *Renal oncocytosis. | ||
==Microscopic== | |||
Three morphologic patterns as per Hes ''et al.'':<ref name=pmid23740406/> | |||
# [[Renal oncocytoma]] and [[chromophobe renal cell carcinoma]] [[collision tumour]]. | |||
#* Different fields viewed in isolation would be compatible with the different diagnoses. Tumour component do not intermingle. | |||
# Renal oncocytoma with scattered chromophobe cells. | |||
# Large eosinophilic cell with intracytoplasmic vacuoles. | |||
DDx: | |||
*[[Renal oncocytoma]] - may have limited chromophobe-like areas (<=5% of tumour).<ref name=pmid21166703>{{Cite journal | last1 = Trpkov | first1 = K. | last2 = Yilmaz | first2 = A. | last3 = Uzer | first3 = D. | last4 = Dishongh | first4 = KM. | last5 = Quick | first5 = CM. | last6 = Bismar | first6 = TA. | last7 = Gokden | first7 = N. | title = Renal oncocytoma revisited: a clinicopathological study of 109 cases with emphasis on problematic diagnostic features. | journal = Histopathology | volume = 57 | issue = 6 | pages = 893-906 | month = Dec | year = 2010 | doi = 10.1111/j.1365-2559.2010.03726.x | PMID = 21166703 }}</ref> | |||
*[[Chromophobe renal cell carcinoma]], eosinophilic variant. | |||
*Other [[renal tumours with eosinophilic cytoplasm]]. | |||
==IHC== | |||
Features:<ref name=pmid23740406/> | |||
*CD117 +ve (practically definitional). | |||
*CK7 +ve (usually). | |||
==See also== | ==See also== | ||
Revision as of 10:28, 15 June 2015
Renal hybrid oncocytic/chromophobe tumour, also hybrid oncocytic/chromophobe tumour (abbreviated HOCT) and hybrid tumour, is a rare kidney tumour with features of chromophobe renal cell carcinoma and renal oncocytoma.[1]
General
- Rare.
- Molecular heterogeneous group[1] - may represent several different entities.
May be seen in several contexts:[1]
- Sporadic.
- Birt–Hogg–Dubé syndrome.
- Renal oncocytosis.
Microscopic
Three morphologic patterns as per Hes et al.:[1]
- Renal oncocytoma and chromophobe renal cell carcinoma collision tumour.
- Different fields viewed in isolation would be compatible with the different diagnoses. Tumour component do not intermingle.
- Renal oncocytoma with scattered chromophobe cells.
- Large eosinophilic cell with intracytoplasmic vacuoles.
DDx:
- Renal oncocytoma - may have limited chromophobe-like areas (<=5% of tumour).[2]
- Chromophobe renal cell carcinoma, eosinophilic variant.
- Other renal tumours with eosinophilic cytoplasm.
IHC
Features:[1]
- CD117 +ve (practically definitional).
- CK7 +ve (usually).
See also
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Hes, O.; Petersson, F.; Kuroda, N.; Hora, M.; Michal, M. (Oct 2013). "Renal hybrid oncocytic/chromophobe tumors - a review.". Histol Histopathol 28 (10): 1257-64. PMID 23740406.
- ↑ Trpkov, K.; Yilmaz, A.; Uzer, D.; Dishongh, KM.; Quick, CM.; Bismar, TA.; Gokden, N. (Dec 2010). "Renal oncocytoma revisited: a clinicopathological study of 109 cases with emphasis on problematic diagnostic features.". Histopathology 57 (6): 893-906. doi:10.1111/j.1365-2559.2010.03726.x. PMID 21166703.