Difference between revisions of "Neutrophil"
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[[Image:Neutrophils.jpg|thumb|right|Neutrophils on a blood film.]] | |||
The '''neutrophil''', [[AKA]] '''polymorphonucleocyte''' or '''PMN''' is a white blood cell. It is often seen in the context of acute inflammation. | The '''neutrophil''', [[AKA]] '''polymorphonucleocyte''' or '''PMN''' is a white blood cell. It is often seen in the context of acute inflammation. | ||
==Histology== | |||
*Little dots = the multilobular nucleus - '''key feature'''. | |||
*Neutrophils are often found with friends, i.e. lymphocytes, plasma cells. | |||
DDx of little dots: | |||
*Nuclear debris - apoptotic cell. | |||
**Apoptotic cell -- has nuclear condensation (pyknosis), eosinophilic cytoplasm. | |||
Notes: | |||
*You find PMNs by their nucleus; on a histologic section don't bother looking for the cell membrane (they are usually impossible to see). | |||
*A collection of PMNs... think about ''[[necrosis]]'' and ''abscess''. | |||
==Pathology== | ==Pathology== | ||
Hypersegmentation = megaloblastic anemia.<ref name=Ref_Klatt63>{{Ref Klatt|63}}</ref> | Hypersegmentation = megaloblastic [[anemia]].<ref name=Ref_Klatt63>{{Ref Klatt|63}}</ref> | ||
==See also== | ==See also== | ||
*[[Basics]]. | *[[Basics]]. | ||
*[[Dysgranulopoiesis]]. | |||
*[[Red blood cell]]. | |||
*[[Chronic granulomatous disease]] - caused by neutrophil dysfunction. | |||
*[[Eosinophil]]. | |||
*[[Auer rods]]. | |||
==References== | ==References== | ||
Latest revision as of 00:08, 28 July 2015
The neutrophil, AKA polymorphonucleocyte or PMN is a white blood cell. It is often seen in the context of acute inflammation.
Histology
- Little dots = the multilobular nucleus - key feature.
- Neutrophils are often found with friends, i.e. lymphocytes, plasma cells.
DDx of little dots:
- Nuclear debris - apoptotic cell.
- Apoptotic cell -- has nuclear condensation (pyknosis), eosinophilic cytoplasm.
Notes:
- You find PMNs by their nucleus; on a histologic section don't bother looking for the cell membrane (they are usually impossible to see).
- A collection of PMNs... think about necrosis and abscess.
Pathology
Hypersegmentation = megaloblastic anemia.[1]
See also
- Basics.
- Dysgranulopoiesis.
- Red blood cell.
- Chronic granulomatous disease - caused by neutrophil dysfunction.
- Eosinophil.
- Auer rods.
References
- ↑ Klatt, Edward C. (2006). Robbins and Cotran Atlas of Pathology (1st ed.). Saunders. pp. 63. ISBN 978-1416002741.