Difference between revisions of "Adamantinoma"

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'''Adamantinoma''' is an uncommon benign [[bone tumour]]. It should '''not''' be confused with ''[[adenomatoid tumour]]''.
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Adamantinoma_-_intermed_mag.jpg
| Width      =
| Caption    = Adamantinoma. [[H&E stain]].
| Micro      = biphasic tumour - epithelial component & fibro-osseous component
| Subtypes  = classic, differentiated
| LMDDx      = [[vascular tumours]] ([[epithelioid hemangioendothelioma]]), [[metastatic carcinoma]]
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[bone]] - classically tibia, other sites
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign +/-locally aggressive
| Other      =
| ClinDDx    = [[osteosarcoma]]
}}
'''Adamantinoma''' is an uncommon benign [[bone tumour]].  
 
It should '''not''' be confused with ''[[adenomatoid tumour]]''.


==General==
==General==
Features:<ref name=Ref_WMSP650>{{Ref WMSP|650}}</ref>
Features:<ref name=Ref_WMSP650>{{Ref WMSP|650}}</ref>
*Rare: < 1% of bone tumours.
*Rare: < 1% of bone tumours.
*25-35 years old.
*Typically 25-35 years old.
*Benign, may be locally aggressive.
*Benign, may be locally aggressive.  
*Cousin of [[ameloblastoma]]. (???)


==Gross==
==Gross==
*Tibia or fibula.
*Classically mid portion of tibia.<ref name=pmid18279517/>
**Fibula common.
**Reported in many other sites.


===Radiology===
===Radiology===
Line 16: Line 48:
==Microscopic==
==Microscopic==
Features:
Features:
*Biphasic tumour:
*Biphasic tumour:<ref name=pmid18279517/>
*#Fibrous/spindle cell component.
*#Fibro-osseous component.
*#*Spindle cells.
*#Epithelial component.
*#Epithelial component.
*#*Classically nests of basaloid cells.
Note:
*It is described as resembling [[ameloblastoma]],<ref name=pmid18279517/> but the resemblance isn't striking.


DDx:<ref name=pathcon_adam>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970057-2 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970057-2]. Accessed on: 28 April 2011.</ref>
DDx:<ref name=pathcon_adam>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970057-2 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970057-2]. Accessed on: 28 April 2011.</ref>
*Vascular tumours ([[Epithelioid hemangioendothelioma]]).
*Vascular tumours ([[epithelioid hemangioendothelioma]]).
*[[Metastatic carcinoma]].
*[[Metastatic carcinoma]].
===Subtypes===
Subdivided into:<ref name=pmid18279517/>
*Classic.
*Differentiated - less than 20 years old only.


===Images===
===Images===
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www:
www:
*[http://southbaypath.org/CaseImages/sb5260/AdamantinomaBiopsy3.jpg Adamantinoma (southbaypath.org)].<ref>URL: [http://southbaypath.org/CaseImages/sb5260/sb5260.htm http://southbaypath.org/CaseImages/sb5260/sb5260.htm]. Accessed on: 7 December 2010.</ref>
*[http://southbaypath.org/CaseImages/sb5260/AdamantinomaBiopsy3.jpg Adamantinoma (southbaypath.org)].<ref>URL: [http://southbaypath.org/CaseImages/sb5260/sb5260.htm http://southbaypath.org/CaseImages/sb5260/sb5260.htm]. Accessed on: 7 December 2010.</ref>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276480/figure/F1/ Adamantinoma (nih.gov)].<ref name=pmid18279517>{{Cite journal  | last1 = Jain | first1 = D. | last2 = Jain | first2 = VK. | last3 = Vasishta | first3 = RK. | last4 = Ranjan | first4 = P. | last5 = Kumar | first5 = Y. | title = Adamantinoma: a clinicopathological review and update. | journal = Diagn Pathol | volume = 3 | issue =  | pages = 8 | month =  | year = 2008 | doi = 10.1186/1746-1596-3-8 | PMID = 18279517 }}</ref>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276480/figure/F2/ Adamantinoma (nih.gov)].
*[http://www.tumorlibrary.com/case/images/1878.jpg Adamantinoma (tumorlibrary.com)].
*[http://www.tumorlibrary.com/case/images/1890.jpg Adamantinoma (tumorlibrary.com)].
*[http://www.tumorlibrary.com/case/images/1891.jpg Adamantinoma (tumorlibrary.com)].
*Epithelium can be focal - Diagnostico Med Br [http://www.diagnostico.med.br/osteopat/54d.JPG]


==IHC==
==IHC==
Features:<ref name=pathcon_adam/>
Features:<ref name=pathcon_adam/>
*CK14 +ve (HMWK).<ref>URL: [http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm]. Accessed on: 28 April 2011.</ref>
*CK14 +ve (HMWK).<ref>URL: [http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm]. Accessed on: 28 April 2011.</ref>
*CK19 +ve (LMWK).
*[[CK19]] +ve (LMWK).
*CK8/18 -ve (LMWK).
*CK8/18 -ve (LMWK).


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==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
==External links==
*[http://www.tumorlibrary.com/case/list.jsp?category=Bone+Tumors&category_type=Adamantinoma&order=diagnosis+ASC Adamantinoma case (tumorlibrary.com)].


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Chondro-osseous tumours]]
[[Category:Chondro-osseous tumours]]

Latest revision as of 21:30, 20 August 2015

Adamantinoma
Diagnosis in short

Adamantinoma. H&E stain.
LM biphasic tumour - epithelial component & fibro-osseous component
Subtypes classic, differentiated
LM DDx vascular tumours (epithelioid hemangioendothelioma), metastatic carcinoma
Site bone - classically tibia, other sites
Prevalence uncommon
Prognosis benign +/-locally aggressive
Clin. DDx osteosarcoma

Adamantinoma is an uncommon benign bone tumour.

It should not be confused with adenomatoid tumour.

General

Features:[1]

  • Rare: < 1% of bone tumours.
  • Typically 25-35 years old.
  • Benign, may be locally aggressive.

Gross

  • Classically mid portion of tibia.[2]
    • Fibula common.
    • Reported in many other sites.

Radiology

  • Intracortical, radiolucent.

Microscopic

Features:

  • Biphasic tumour:[2]
    1. Fibro-osseous component.
      • Spindle cells.
    2. Epithelial component.
      • Classically nests of basaloid cells.

Note:

  • It is described as resembling ameloblastoma,[2] but the resemblance isn't striking.

DDx:[3]

Subtypes

Subdivided into:[2]

  • Classic.
  • Differentiated - less than 20 years old only.

Images

  • Adamantinoma - intermed. mag. (WC)

www:

IHC

Features:[3]

  • CK14 +ve (HMWK).[5]
  • CK19 +ve (LMWK).
  • CK8/18 -ve (LMWK).

See also

References

  1. ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 650. ISBN 978-0781765275.
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Jain, D.; Jain, VK.; Vasishta, RK.; Ranjan, P.; Kumar, Y. (2008). "Adamantinoma: a clinicopathological review and update.". Diagn Pathol 3: 8. doi:10.1186/1746-1596-3-8. PMID 18279517.
  3. ↑ 3.0 3.1 URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970057-2. Accessed on: 28 April 2011.
  4. ↑ URL: http://southbaypath.org/CaseImages/sb5260/sb5260.htm. Accessed on: 7 December 2010.
  5. ↑ URL: http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm. Accessed on: 28 April 2011.

External links

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