Difference between revisions of "Lymphoepithelioma-like carcinoma of the urinary bladder"
Jump to navigation
Jump to search
| Line 42: | Line 42: | ||
**Central nuclei +/- small/indistinct nucleoli. | **Central nuclei +/- small/indistinct nucleoli. | ||
**Surrounded by a prominent lymphoid component - '''key feature'''. | **Surrounded by a prominent lymphoid component - '''key feature'''. | ||
*+/-[[Urothelial carcinoma in situ]]. | |||
DDx: | DDx: | ||
| Line 60: | Line 61: | ||
</ref> | </ref> | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881438/figure/F0003/ LELC of the urinary bladder - high mag. (nih.gov)].<ref name=pmid19847088/> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881438/figure/F0003/ LELC of the urinary bladder - high mag. (nih.gov)].<ref name=pmid19847088/> | ||
==IHC== | |||
Features:<ref name=pmid21383609/> | |||
*p53 +ve/-ve. | |||
*CK20 -ve. | |||
*TTF-1 -ve. | |||
*CD30 -ve. | |||
*CK34betaE12 +ve (+ve in 75% of cases). | |||
*CK7 +ve/-ve (+ve in ~60% of cases). | |||
*p63 +ve/-ve (+ve in ~50% of cases). | |||
==See also== | ==See also== | ||
Revision as of 20:19, 5 September 2015
| Lymphoepithelioma-like carcinoma of the urinary bladder | |
|---|---|
| Diagnosis in short | |
 Urinary bladder lymphoepithelioma-like carcinoma. H&E stain. | |
|
| |
| LM | squamoid cells with abundant dense cytoplasm central nuclei +/- small/indistinct nucleoli, prominent lymphoid infiltrate |
| Subtypes | subtype of urothelial carcinoma |
| LM DDx | lymphoma, urothelial carcinoma and inflammation, metastatic lymphoepithelioma-like carcinoma |
| Site | urinary bladder - see urothelium |
|
| |
| Prevalence | rare |
| Other | not associated with EBV |
Lymphoepithelioma-like carcinoma of the urinary bladder, also urinary bladder lymphoepithelioma-like carcinoma (abbreviated UBLELC), is a rare variant of urothelial carcinoma.[1]
General
Microscopic
Features:
- Clusters of (cohesive) squamoid cells with:
- Abundant dense cytoplasm.
- Central nuclei +/- small/indistinct nucleoli.
- Surrounded by a prominent lymphoid component - key feature.
- +/-Urothelial carcinoma in situ.
DDx:
- Lymphoma.
- Urothelial carcinoma and inflammation.
- Metastatic lymphoepithelioma-like carcinoma.
Images
UBLELC - low mag. (WC)
UBLELC - intermed. mag. (WC)
UBLELC - intermed. mag. (WC)
UBLELC - high mag. (WC)
UBLELC - very high mag. (WC)
www:
- LELC of the urinary bladder - low mag. (nih.gov).[3]
- LELC of the urinary bladder - high mag. (nih.gov).[3]
IHC
Features:[2]
- p53 +ve/-ve.
- CK20 -ve.
- TTF-1 -ve.
- CD30 -ve.
- CK34betaE12 +ve (+ve in 75% of cases).
- CK7 +ve/-ve (+ve in ~60% of cases).
- p63 +ve/-ve (+ve in ~50% of cases).
See also
References
- ↑ Amin, MB. (Jun 2009). "Histological variants of urothelial carcinoma: diagnostic, therapeutic and prognostic implications.". Mod Pathol 22 Suppl 2: S96-S118. doi:10.1038/modpathol.2009.26. PMID 19494856.
- ↑ 2.0 2.1 Williamson, SR.; Zhang, S.; Lopez-Beltran, A.; Shah, RB.; Montironi, R.; Tan, PH.; Wang, M.; Baldridge, LA. et al. (Apr 2011). "Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features.". Am J Surg Pathol 35 (4): 474-83. doi:10.1097/PAS.0b013e31820f709e. PMID 21383609.
- ↑ 3.0 3.1 Singh, NG.; Mannan, AA.; Rifaat, AA.; Kahvic, M.. "Lymphoepithelioma-like carcinoma of the urinary bladder: report of a rare case.". Ann Saudi Med 29 (6): 478-81. doi:10.4103/0256-4947.57173. PMID 19847088.