Difference between revisions of "Case 105"
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Low magnification. H&E stain.
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<center>Low magnification. [[H&E stain]].</center> | <center>Low magnification. [[H&E stain]].</center> | ||
{{hidden| | {{hidden|Low magnification|[[Image: Highly cellular leiomyoma at edge to myometrium at 20x.jpg |500px|link=|center|]] | ||
<center>Low magnification. [[H&E stain]].</center>}} | <center>Low magnification. [[H&E stain]].</center>}} | ||
{{hidden| | {{hidden|Low magnification|[[Image: Highly cellular leiomyoma on showing thick walled vessels at 20x.jpg |500px|link=|center|]] | ||
<center>Low magnification. [[H&E stain]].</center>}} | <center>Low magnification. [[H&E stain]].</center>}} | ||
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===Differential diagnosis=== | ===Differential diagnosis=== | ||
{{hidden|Differential diagnosis|<center> | {{hidden|Differential diagnosis|<center>Endometrial stromal neoplasm - nodule vs sarcoma </center>}} | ||
===Additional tests=== | ===Additional tests=== | ||
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====Ask a colleague==== | ====Ask a colleague==== | ||
{{hidden|Ask a colleague|<center> | {{hidden|Ask a colleague|<center> Would immunostains help? </center>}} | ||
====Stains==== | ====Stains==== | ||
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===Diagnosis=== | ===Diagnosis=== | ||
{{hidden|Diagnosis|<center>HIGHLY CELLULAR LEIOMYOMA</center>}} | {{hidden|Diagnosis|<center>[[Uterine leiomyoma|HIGHLY CELLULAR LEIOMYOMA]]</center> | ||
<br>Comment:<br>The differential diagnosis is between an endometrial stromal tumor ([[endometrial stromal nodule]], [[endometrial stromal sarcoma]]) and a highly cellular leiomyoma. Although the immunohistochemical stains can be helpful if CD10 negative, a high percentage of cellular leiomyoma mark with CD10, a stain traditionally assumed to mark stromal tumors. Conversely, endometrial stromal neoplasms with smooth muscle differentiation will mark with muscle markers. | |||
<br><br>The characteristic features of highly cellular leiomyoma are the cleft like spaces at the edge of the tumor, the thick-walled vessels within the tumor, and the "spindled" spindle cells as opposed to rounded spindled cells. They also lack the spiral arterioles characteristic of endometrial stromal neoplasms. The edge of a cellular leiomyoma is often irregular, sometimes raising concern not for an endometrial stromal nodule (which if misdiagnosed as, has no clinical implications) but for an endometrial stromal sarcoma (which does have prognostic and surgical implications). The irregular tongues of tumor in cellular leiomyoma are generally small, do not extend for more than a few millimeters beyond the tumor and "fade" into the surrounding myometrium; whereas these tongues are sharply circumscribed in endometrial stromal sarcoma. | |||
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===Other cases=== | ===Other cases=== | ||
{{Cases navigation}} | {{Cases navigation}} | ||
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[[Category:Cases]] | [[Category:Cases]] | ||
[[Category:Cases in gynecologic pathology]] | [[Category:Cases in gynecologic pathology]] | ||
- | [[Category:Cases in gynecologic pathology - senior]] | ||
[[Category:Cases difficulty 4]] <!-- difficulty 1-7 -- should roughly correspond to the PGY level --> | [[Category:Cases difficulty 4]] <!-- difficulty 1-7 -- should roughly correspond to the PGY level --> | ||
Latest revision as of 04:28, 24 September 2015
Provided clinical history
56 year old woman, with history of increased menstrual bleeding. 4.5 cm mass on ultrasound of the uterus
Site
Uterus- stromal
Primary image
Low magnification
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Low magnification
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High magnification
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Differential diagnosis
Differential diagnosis
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Additional tests
More history
More history
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Ask a colleague
Ask a colleague
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Stains
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IHC
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Molecular testing
Chromosomal translocations
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Other molecular tests
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Diagnosis
Diagnosis
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