Difference between revisions of "Adenocarcinoma of the rete testis"
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| Caption = Adenocarcinoma of the rete testis. [[H&E stain]]. | | Caption = Adenocarcinoma of the rete testis. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = | ||
| Micro = | | Micro = atypical columnar or cuboidal cells, often with cigar-shaped nuclei; classically tubular or papillary architecture; transistion to normal appearing rete testis | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[adenomatous hyperplasia of the rete testis]], [[Sertoli cell tumour]], [[malignant mesothelioma]], metastasis | | LMDDx = [[adenomatous hyperplasia of the rete testis]], [[Sertoli cell tumour]], [[malignant mesothelioma]], metastasis | ||
| Stains = | | Stains = | ||
| IHC = EMA +ve, CK7 +ve, PSA -ve, calretinin -ve, CK5/6 -ve, PLAP -ve, AFP -ve, CD30 -ve | | IHC = EMA +ve, [[CK7]] +ve, PSA -ve, calretinin -ve, CK5/6 -ve, PLAP -ve, [[AFP]] -ve, CD30 -ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
| Line 15: | Line 15: | ||
| Gross = hilar mass | | Gross = hilar mass | ||
| Grossing = [[orchiectomy grossing]] | | Grossing = [[orchiectomy grossing]] | ||
| Site = [[testis]] - | | Site = [[paratesticular region]]/[[testis]] - see ''[[rete testis]]'' | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
| Line 22: | Line 22: | ||
| Symptoms = | | Symptoms = | ||
| Prevalence = extremely rare | | Prevalence = extremely rare | ||
| Bloodwork = | | Bloodwork = markers for GCT typically normal | ||
| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = | ||
| Line 30: | Line 30: | ||
| Tx = | | Tx = | ||
}} | }} | ||
'''Adenocarcinoma of the rete testis''', also '''rete testis adenocarcinoma''', is a very rare [[malignant]] tumour of the [[testis]]. | '''Adenocarcinoma of the rete testis''', also '''rete testis adenocarcinoma''', is a very rare [[malignant]] tumour of the [[paratesticular region]]/[[testis]]. | ||
==General== | ==General== | ||
*Extremely rare<ref name=pmid6465420>{{Cite journal | last1 = Nochomovitz | first1 = LE. | last2 = Orenstein | first2 = JM. | title = Adenocarcinoma of the rete testis. Case report, ultrastructural observations, and clinicopathologic correlates. | journal = Am J Surg Pathol | volume = 8 | issue = 8 | pages = 625-34 | month = Aug | year = 1984 | doi = | PMID = 6465420 }}</ref> - a few dozen cases in the world literature. | *Extremely rare<ref name=pmid6465420>{{Cite journal | last1 = Nochomovitz | first1 = LE. | last2 = Orenstein | first2 = JM. | title = Adenocarcinoma of the rete testis. Case report, ultrastructural observations, and clinicopathologic correlates. | journal = Am J Surg Pathol | volume = 8 | issue = 8 | pages = 625-34 | month = Aug | year = 1984 | doi = | PMID = 6465420 }}</ref> - a few dozen cases in the world literature. | ||
*Typically older men (>60 years old), but reported in younger men with undescended testis.<ref name=pmid6465420/> | *Typically older men (>60 years old), but reported in younger men with undescended testis.<ref name=pmid6465420/> | ||
*Possible association | *Possible association with diethylstilbestrol - based on non-human data.<ref name=pmid3799821>{{Cite journal | last1 = Newbold | first1 = RR. | last2 = Bullock | first2 = BC. | last3 = McLachlan | first3 = JA. | title = Adenocarcinoma of the rete testis. Diethylstilbestrol-induced lesions of the mouse rete testis. | journal = Am J Pathol | volume = 125 | issue = 3 | pages = 625-8 | month = Dec | year = 1986 | doi = | PMID = 3799821 | PMC = 1888460 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888460/?page=1}}</ref> | ||
*Prognosis poor<ref name=pmid17853037>{{Cite journal | last1 = Sogni | first1 = F. | last2 = Monga | first2 = G. | last3 = Terrone | first3 = C. | last4 = Gontero | first4 = P. | title = Primary adenocarcinoma of the rete testis: diagnostic problems and therapeutic dilemmas. | journal = Scand J Urol Nephrol | volume = 42 | issue = 1 | pages = 83-5 | month = | year = 2008 | doi = 10.1080/00365590701517608 | PMID = 17853037 }}</ref> - 3-year and 5-year disease-free survival approximately 50% and 15% respectively.<ref name=pmid7571213>{{Cite journal | last1 = Sánchez-Chapado | first1 = M. | last2 = Angulo | first2 = JC. | last3 = Haas | first3 = GP. | title = Adenocarcinoma of the rete testis. | journal = Urology | volume = 46 | issue = 4 | pages = 468-75 | month = Oct | year = 1995 | doi = 10.1016/S0090-4295(99)80257-X | PMID = 7571213 }}</ref> | *Prognosis poor<ref name=pmid17853037>{{Cite journal | last1 = Sogni | first1 = F. | last2 = Monga | first2 = G. | last3 = Terrone | first3 = C. | last4 = Gontero | first4 = P. | title = Primary adenocarcinoma of the rete testis: diagnostic problems and therapeutic dilemmas. | journal = Scand J Urol Nephrol | volume = 42 | issue = 1 | pages = 83-5 | month = | year = 2008 | doi = 10.1080/00365590701517608 | PMID = 17853037 }}</ref> - 3-year and 5-year disease-free survival approximately 50% and 15% respectively.<ref name=pmid7571213>{{Cite journal | last1 = Sánchez-Chapado | first1 = M. | last2 = Angulo | first2 = JC. | last3 = Haas | first3 = GP. | title = Adenocarcinoma of the rete testis. | journal = Urology | volume = 46 | issue = 4 | pages = 468-75 | month = Oct | year = 1995 | doi = 10.1016/S0090-4295(99)80257-X | PMID = 7571213 }}</ref> | ||
Clinical: | |||
*[[Germ cell tumour]] serum markers (LDH, AFP, beta-hCG) typically normal. | |||
==Gross== | ==Gross== | ||
| Line 45: | Line 48: | ||
*Adenocarcinoma: | *Adenocarcinoma: | ||
**Atypical columnar or cuboidal cells, often with cigar-shaped nuclei. | **Atypical columnar or cuboidal cells, often with cigar-shaped nuclei. | ||
** | **Classically tubular or papillary architecture.<ref name=pmid3799821/> | ||
*Transistion to normal appearing rete testis.<ref name=pmid6465420/> | *Transistion to normal appearing rete testis.<ref name=pmid6465420/> | ||
| Line 69: | Line 72: | ||
==IHC== | ==IHC== | ||
Features:<ref name=pmid23800084/> | Features:<ref name=pmid23800084/> | ||
*CK7 +ve. | *[[CK7]] +ve. | ||
*EMA +ve. | *[[EMA]] +ve. | ||
Others:<ref name=pmid23800084/> | Others:<ref name=pmid23800084/> | ||
*AFP -ve. | *[[AFP]] -ve. | ||
*CD30 -ve. | *CD30 -ve. | ||
*PLAP -ve. | *PLAP -ve. | ||
*CK5/6 -ve. | *CK5/6 -ve. | ||
*Calretinin -ve. | *Calretinin -ve. | ||
*PSA -ve. | *[[PSA]] -ve. | ||
==See also== | ==See also== | ||
Latest revision as of 21:56, 29 September 2015
| Adenocarcinoma of the rete testis | |
|---|---|
| Diagnosis in short | |
 Adenocarcinoma of the rete testis. H&E stain. | |
|
| |
| LM | atypical columnar or cuboidal cells, often with cigar-shaped nuclei; classically tubular or papillary architecture; transistion to normal appearing rete testis |
| LM DDx | adenomatous hyperplasia of the rete testis, Sertoli cell tumour, malignant mesothelioma, metastasis |
| IHC | EMA +ve, CK7 +ve, PSA -ve, calretinin -ve, CK5/6 -ve, PLAP -ve, AFP -ve, CD30 -ve |
| Gross | hilar mass |
| Grossing notes | orchiectomy grossing |
| Site | paratesticular region/testis - see rete testis |
|
| |
| Prevalence | extremely rare |
| Blood work | markers for GCT typically normal |
| Prognosis | poor |
| Clin. DDx | other testicular mass |
Adenocarcinoma of the rete testis, also rete testis adenocarcinoma, is a very rare malignant tumour of the paratesticular region/testis.
General
- Extremely rare[1] - a few dozen cases in the world literature.
- Typically older men (>60 years old), but reported in younger men with undescended testis.[1]
- Possible association with diethylstilbestrol - based on non-human data.[2]
- Prognosis poor[3] - 3-year and 5-year disease-free survival approximately 50% and 15% respectively.[4]
Clinical:
- Germ cell tumour serum markers (LDH, AFP, beta-hCG) typically normal.
Gross
- Lesion of the testicular hilum.[1]
Microscopic
Features:
- Adenocarcinoma:
- Atypical columnar or cuboidal cells, often with cigar-shaped nuclei.
- Classically tubular or papillary architecture.[2]
- Transistion to normal appearing rete testis.[1]
DDx:
- Adenomatous hyperplasia of the rete testis - may be a concurrent pathology.[5]
- Metastatic carcinoma involving the testis - usually prostate, kidney, or colon.[6]
- Sertoli cell tumour.
- Malignant mesothelioma.[1]
Images
ART - low mag. (WC)
ART - intermed. mag. (WC)
ART - high mag. (WC)
ART - high mag. (WC)
ART - very high mag. (WC)
www:
IHC
Features:[5]
Others:[5]
See also
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Nochomovitz, LE.; Orenstein, JM. (Aug 1984). "Adenocarcinoma of the rete testis. Case report, ultrastructural observations, and clinicopathologic correlates.". Am J Surg Pathol 8 (8): 625-34. PMID 6465420.
- ↑ 2.0 2.1 Newbold, RR.; Bullock, BC.; McLachlan, JA. (Dec 1986). "Adenocarcinoma of the rete testis. Diethylstilbestrol-induced lesions of the mouse rete testis.". Am J Pathol 125 (3): 625-8. PMC 1888460. PMID 3799821. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888460/.
- ↑ Sogni, F.; Monga, G.; Terrone, C.; Gontero, P. (2008). "Primary adenocarcinoma of the rete testis: diagnostic problems and therapeutic dilemmas.". Scand J Urol Nephrol 42 (1): 83-5. doi:10.1080/00365590701517608. PMID 17853037.
- ↑ Sánchez-Chapado, M.; Angulo, JC.; Haas, GP. (Oct 1995). "Adenocarcinoma of the rete testis.". Urology 46 (4): 468-75. doi:10.1016/S0090-4295(99)80257-X. PMID 7571213.
- ↑ 5.0 5.1 5.2 Lin, XY.; Yu, JH.; Xu, HT.; Wang, L.; Fan, CF.; Liu, Y.; Wang, EH. (2013). "A case of adenocarcinoma of the rete testis accompanied by focal adenomatous hyperplasia.". Diagn Pathol 8: 105. doi:10.1186/1746-1596-8-105. PMID 23800084.
- ↑ Ulbright, TM.; Young, RH. (Nov 2008). "Metastatic carcinoma to the testis: a clinicopathologic analysis of 26 nonincidental cases with emphasis on deceptive features.". Am J Surg Pathol 32 (11): 1683-93. doi:10.1097/PAS.0b013e3181788516. PMID 18769334.
- ↑ Yang, Z.; Sheng, C.; Cao, L.; Wang, D.. "Adenocarcinoma of rete testis with widespread liver metastasis.". Can Urol Assoc J 7 (9-10): E654-6. doi:10.5489/cuaj.470. PMID 24409217.
- ↑ Tian, Y.; Yao, W.; Yang, L.; Wang, J.; Wazir, R.; Wang, K. (Feb 2014). "Primary adenocarcinoma of the rete testis: A case report and review of the literature.". Oncol Lett 7 (2): 455-457. doi:10.3892/ol.2013.1708. PMID 24396468.
- ↑ Wu, CA.; Chen, YH.; Man, KM.; Shen, JL.; Chen, WC. (2011). "Papillary adenocarcinoma of rete testis mimics inflammatory lump: a case report.". Case Rep Urol 2011: 857812. doi:10.1155/2011/857812. PMID 22606627.