Difference between revisions of "Invasive cribriform carcinoma of the breast"
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| Micro = cribriform architecture, stromal desmoplasia, +/-tubular component | | Micro = cribriform architecture, stromal desmoplasia, +/-tubular component | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[tubular carcinoma of the breast|tubular carcinoma]], cribriform [[DCIS]], mixed tumour (e.g. ICC with [[invasive ductal carcinoma of the breast|IDC]] | | LMDDx = [[tubular carcinoma of the breast|tubular carcinoma]], cribriform [[DCIS]], mixed tumour (e.g. ICC with [[invasive ductal carcinoma of the breast|IDC]]), [[adenoid cystic carcinoma of the breast]] | ||
| Stains = | | Stains = | ||
| IHC = ER +ve, PR +ve, HER2 -ve | | IHC = ER +ve, PR +ve, HER2 -ve | ||
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==Microscopic== | ==Microscopic== | ||
Features: | Features:<ref name=pmid23412348/> | ||
*Cribriform architecture. | *[[Cribriform]] (or sieve-like) architecture. | ||
*[[Desmoplastic stroma]]. | *[[Desmoplastic stroma]]. | ||
*+/-[[Tubular carcinoma of the breast|Tubular]] component. | *+/-[[Tubular carcinoma of the breast|Tubular]] component. | ||
Notes: | |||
*Cribriform component should be >90% of the tumour.<ref name=pmid23412348>{{Cite journal | last1 = Zhang | first1 = W. | last2 = Zhang | first2 = T. | last3 = Lin | first3 = Z. | last4 = Zhang | first4 = X. | last5 = Liu | first5 = F. | last6 = Wang | first6 = Y. | last7 = Liu | first7 = H. | last8 = Yang | first8 = Y. | last9 = Niu | first9 = Y. | title = Invasive cribriform carcinoma in a Chinese population: comparison with low-grade invasive ductal carcinoma-not otherwise specified. | journal = Int J Clin Exp Pathol | volume = 6 | issue = 3 | pages = 445-57 | month = | year = 2013 | doi = | PMID = 23412348 }}</ref> | *Cribriform component should be >90% of the tumour.<ref name=pmid23412348>{{Cite journal | last1 = Zhang | first1 = W. | last2 = Zhang | first2 = T. | last3 = Lin | first3 = Z. | last4 = Zhang | first4 = X. | last5 = Liu | first5 = F. | last6 = Wang | first6 = Y. | last7 = Liu | first7 = H. | last8 = Yang | first8 = Y. | last9 = Niu | first9 = Y. | title = Invasive cribriform carcinoma in a Chinese population: comparison with low-grade invasive ductal carcinoma-not otherwise specified. | journal = Int J Clin Exp Pathol | volume = 6 | issue = 3 | pages = 445-57 | month = | year = 2013 | doi = | PMID = 23412348 | PMC = 3563205}}</ref> | ||
*Low or intermediate Nottingham grade. | |||
DDx: | DDx: | ||
| Line 51: | Line 51: | ||
*[[Tubular carcinoma of the breast]]. | *[[Tubular carcinoma of the breast]]. | ||
*[[Invasive ductal carcinoma of the breast]] with cribriform component. | *[[Invasive ductal carcinoma of the breast]] with cribriform component. | ||
*[[Adenoid cystic carcinoma of the breast]]. | |||
===Images=== | ===Images=== | ||
Latest revision as of 03:58, 31 October 2015
| Invasive cribriform carcinoma of the breast | |
|---|---|
| Diagnosis in short | |
 Invasive cribriform carcinoma of the breast. H&E stain. | |
|
| |
| LM | cribriform architecture, stromal desmoplasia, +/-tubular component |
| LM DDx | tubular carcinoma, cribriform DCIS, mixed tumour (e.g. ICC with IDC), adenoid cystic carcinoma of the breast |
| IHC | ER +ve, PR +ve, HER2 -ve |
| Site | breast |
|
| |
| Prevalence | very rare |
| Prognosis | good |
| Treatment | surgical |
Invasive cribriform carcinoma of the breast is a rare type of breast cancer with a favourable prognosis.[1]
General
- Rare ~ 0.6% of breast cancer in one series.[2]
- Low grade.
- Good prognosis if pure or associated with a tubular invasive component.[3]
Microscopic
Features:[4]
- Cribriform (or sieve-like) architecture.
- Desmoplastic stroma.
- +/-Tubular component.
Notes:
- Cribriform component should be >90% of the tumour.[4]
- Low or intermediate Nottingham grade.
DDx:
- Cribriform DCIS.
- Tubular carcinoma of the breast.
- Invasive ductal carcinoma of the breast with cribriform component.
- Adenoid cystic carcinoma of the breast.
Images
Breast invasive cribriform carcinoma - low power. (SKB)
Breast invasive cribriform carcinoma - medium power. (SKB)
Breast invasive cribriform carcinoma - high power. (SKB)
www:
IHC
Features:[1]
- ER +ve (9 +ve of 9 cases).
- PR +ve (9 +ve of 9 cases).
- HER2 -ve (0 +ve of 9 cases).
See also
References
- ↑ 1.0 1.1 Cong, Y.; Qiao, G.; Zou, H.; Lin, J.; Wang, X.; Li, X.; Li, Y.; Zhu, S. (Apr 2015). "Invasive cribriform carcinoma of the breast: A report of nine cases and a review of the literature.". Oncol Lett 9 (4): 1753-1758. doi:10.3892/ol.2015.2972. PMID 25789036.
- ↑ Stutz, JA.; Evans, AJ.; Pinder, S.; Ellis, IO.; Yeoman, LJ.; Wilson, AR.; Sibbering, DM. (Oct 1994). "The radiological appearances of invasive cribriform carcinoma of the breast. Nottingham Breast Team.". Clin Radiol 49 (10): 693-5. PMID 7955831.
- ↑ Page, DL.; Dixon, JM.; Anderson, TJ.; Lee, D.; Stewart, HJ. (Jul 1983). "Invasive cribriform carcinoma of the breast.". Histopathology 7 (4): 525-36. PMID 6884999.
- ↑ 4.0 4.1 4.2 Zhang, W.; Zhang, T.; Lin, Z.; Zhang, X.; Liu, F.; Wang, Y.; Liu, H.; Yang, Y. et al. (2013). "Invasive cribriform carcinoma in a Chinese population: comparison with low-grade invasive ductal carcinoma-not otherwise specified.". Int J Clin Exp Pathol 6 (3): 445-57. PMC 3563205. PMID 23412348. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563205/.