Difference between revisions of "Lobular capillary hemangioma"

Lobular capillary hemangioma
	Diagnosis in short
	; Lobular capillary hemangioma. H&E stain.
Synonyms	pyogenic granuloma
LM	polypoid or peduculated lesion, vascular - with plump endothelium, usu. thinned epithelium or ulcerated, lobular arrangement of vascular (seen at low power)
LM DDx	capillary hemangioma, myopericytoma (?), bacillary angiomatosis
Site	head and neck - lips, tongue, gingiva
Clinical history	+/-rapid growth, young adults, children and pregnant women
Prognosis	benign

Revision as of 18:24, 6 December 2015

Lobular capillary hemangioma, also known as pyogenic granuloma,^[1] a benign head and neck lesion that can mimic malignancy.

On occasion it is referred to as pregnancy tumour.

General

Seen in children, young adults, pregnant women.

Clinical:

May grow quickly - clinically suspicious for a malignancy.

Note:

Pyogenic granuloma is a misnomer:
- Not pyogenic, i.e. infectious.
- Not granulomatous.
The WMSP advocates the name lobular capillary hemangioma.^[2]

Gross

Features:^[3]

Erythematous.
Hemorrhagic.

Usually location:^[2]

Lips.
Tongue.
Gingiva.

Microscopic

Features:^[4]

Polypoid or peduculated.
Vascular, i.e. many blood vessels, with plump endothelium.
Usu. thinned epithelium^[5] or ulcerated.^[2]
Lobular arrangement of vascular (seen at low power).^[6]

DDx:

Why it is not...

Glomus tumour - cookie cutter arrangement of cells.

Image

Pyogenic granuloma. (WC)

www:

Pyogenic granuloma (sciencephoto.com).

IHC

Features - positive for vascular markers:^[2]

CD34 +ve.
CD31 +ve.
Factor VIII +ve.
SMA +ve -- marks pericytes.^{[citation needed]}

A panel:

CD31, SMA, HMB-45.

Sign out

Tongue Lesion, Excision:
- Lobular capillary hemangioma (pyogenic granuloma).

Block letters

TONGUE, LEFT LATERAL, BIOPSY:
- LOBULAR CAPILLARY HEMANGIOMA (PYOGENIC GRANULOMA).

LESION, POSTERIOR TO LEFT EAR, EXCISION:
- LOBULAR CAPILLARY HEMANGIOMA (PYOGENIC GRANULOMA).

COMMENT:
The lesion stains as follows:
POSITIVE: SMA, CD31.
NEGATIVE: S-100, HMB-45.

Micro

The sections shows a pendunculated vascular lesion with small capillaries arranged in a lobular fashion. The endothelial cells of the lesion show no atypia. The overlying acanthotic epidermis has hyperkeratosis and hypergranulosis, and is focally ulcerated and impetiginized. There is no significant keratocyte atypia. No melanocytic nests are seen. The dermis has a mild perivascular lymphoplasmacytic infiltrate. The lesion is excised in the plane of section.

Alternate - tongue

The sections shows a pendunculated vascular lesion with small capillaries arranged in a lobular fashion. The endothelial cells of the lesion show no significant atypia. The overlying epithelium is largely eroded. There is no significant keratocyte atypia. The lesion is excised in the plane of section.

References

↑ Baglin, AC. (Aug 2011). "[Vascular tumors and pseudotumors. Pyogenic granuloma (lobular capillary hemangioma)].". Ann Pathol 31 (4): 266-70. doi:10.1016/j.annpat.2011.05.014. PMID 21839350.
↑ ^2.0 ^2.1 ^2.2 ^2.3 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 12. ISBN 978-0781765275.
↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 776. ISBN 0-7216-0187-1.
↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 775. ISBN 0-7216-0187-1.
↑ URL: http://basicpathology-histopathology.blogspot.com/2009/10/head-and-neck-oral-cavity-reactive_3282.html. Accessed on: 2 February 2011.
↑ S. Sade. 8 September 2011.
↑ Levy, I.; Rolain, JM.; Lepidi, H.; Raoult, D.; Feinmesser, M.; Lapidoth, M.; Ben-Amitai, D. (Dec 2005). "Is pyogenic granuloma associated with Bartonella infection?". J Am Acad Dermatol 53 (6): 1065-6. doi:10.1016/j.jaad.2005.08.046. PMID 16310070.

[pmid21839350-1] Baglin, AC. (Aug 2011). "[Vascular tumors and pseudotumors. Pyogenic granuloma (lobular capillary hemangioma)].". Ann Pathol 31 (4): 266-70. doi:10.1016/j.annpat.2011.05.014. PMID 21839350.

[Ref_WMSP12-2] 2.0 ^2.1 ^2.2 ^2.3 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 12. ISBN 978-0781765275.

[Ref_PBoD776-3] Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 776. ISBN 0-7216-0187-1.

[Ref_PBoD775-4] Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 775. ISBN 0-7216-0187-1.

[5] URL: http://basicpathology-histopathology.blogspot.com/2009/10/head-and-neck-oral-cavity-reactive_3282.html. Accessed on: 2 February 2011.

[6] S. Sade. 8 September 2011.

[pmid16310070-7] Levy, I.; Rolain, JM.; Lepidi, H.; Raoult, D.; Feinmesser, M.; Lapidoth, M.; Ben-Amitai, D. (Dec 2005). "Is pyogenic granuloma associated with Bartonella infection?". J Am Acad Dermatol 53 (6): 1065-6. doi:10.1016/j.jaad.2005.08.046. PMID 16310070.

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