Difference between revisions of "Carney complex"
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The '''Carney complex''', also known as '''NAME syndrome''' and '''LAMB syndrome''', is a bunch of things that occur together due to some genetic problem.<ref name=Ref_WMSP135>{{Ref WMSP|135}}</ref> It should not be confused with the [[Carney triad]]. | The '''Carney complex''', also known as '''Carney syndrome''', '''NAME syndrome''' and '''LAMB syndrome''', is a bunch of things that occur together due to some genetic problem.<ref name=Ref_WMSP135>{{Ref WMSP|135}}</ref> It should not be confused with the [[Carney triad]]. | ||
NAME and LAMB are acronyms that were proposed later.<ref name=emed1097150o>URL: [http://emedicine.medscape.com/article/1097150-overview http://emedicine.medscape.com/article/1097150-overview]. Accessed on: 25 May 2011.</ref> | |||
NAME and LAMB | In addition to the elements in ''NAME'' and ''LAMB'', it includes: | ||
*[[Pituitary adenoma]].<ref name=Ref_PCPBoD8_554>{{Ref PCPBoD8|554}}</ref> | |||
*[[Psammomatous melanotic schwannoma]].<ref name=emed1097150o>URL: [http://emedicine.medscape.com/article/1097150-overview http://emedicine.medscape.com/article/1097150-overview]. Accessed on: 25 May 2011.</ref> | |||
==Types== | ==Types== | ||
Two types exist: | Two types exist: | ||
*Carney complex type 1.<ref name=omim160980>{{OMIM|160980}}</ref> | *Carney complex type 1.<ref name=omim160980>{{OMIM|160980}}</ref> | ||
**PRKAR1A gene. | |||
*Carney complex type 2.<ref name=omim605244>{{OMIM|605244}}</ref> | *Carney complex type 2.<ref name=omim605244>{{OMIM|605244}}</ref> | ||
**CNC gene. | |||
==Acronyms== | ==Acronyms== | ||
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*Myxoid [[neurofibroma]]. | *Myxoid [[neurofibroma]]. | ||
*Ephelides (freckles<ref>URL: [http://emedicine.medscape.com/article/1119293-overview http://emedicine.medscape.com/article/1119293-overview]. Accessed on: 7 January 2011.</ref>). | *Ephelides (freckles<ref>URL: [http://emedicine.medscape.com/article/1119293-overview http://emedicine.medscape.com/article/1119293-overview]. Accessed on: 7 January 2011.</ref>). | ||
**Pronounced ''e-FEE-le-DEEs''.<ref>URL: [http://www.merriam-webster.com/medlineplus/ephelides http://www.merriam-webster.com/medlineplus/ephelides]. Accessed on: 8 February 2012.</ref> | |||
===LAMB=== | ===LAMB=== | ||
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*Mucocutaneous myxomas. | *Mucocutaneous myxomas. | ||
*[[Blue nevi]]. | *[[Blue nevi]]. | ||
Notes: | |||
*Large calcifying [[sertoli cell tumours]] are also described in association ''Carney complex''.<ref name=pmid22732638>{{Cite journal | last1 = Gourgari | first1 = E. | last2 = Saloustros | first2 = E. | last3 = Stratakis | first3 = CA. | title = Large-cell calcifying Sertoli cell tumors of the testes in pediatrics. | journal = Curr Opin Pediatr | volume = 24 | issue = 4 | pages = 518-22 | month = Aug | year = 2012 | doi = 10.1097/MOP.0b013e328355a279 | PMID = 22732638 }}</ref> | |||
==See also== | ==See also== | ||
*[[Peutz-Jeghers syndrome]]. | *[[Peutz-Jeghers syndrome]]. | ||
*[[Carney triad]]. | *[[Carney triad]]. | ||
*[[Carney-Stratakis syndrome]]. | |||
*[[Myxoid lesions]]. | *[[Myxoid lesions]]. | ||
Latest revision as of 04:05, 15 March 2016
The Carney complex, also known as Carney syndrome, NAME syndrome and LAMB syndrome, is a bunch of things that occur together due to some genetic problem.[1] It should not be confused with the Carney triad.
NAME and LAMB are acronyms that were proposed later.[2]
In addition to the elements in NAME and LAMB, it includes:
Types
Two types exist:
Acronyms
NAME
NAME:
- Nevi.
- Atrial myxoma.
- Myxoid neurofibroma.
- Ephelides (freckles[6]).
- Pronounced e-FEE-le-DEEs.[7]
LAMB
LAMB:
- Lentigines.
- Focal melanocyte hyperplasia.
- Atrial myxomas.
- Mucocutaneous myxomas.
- Blue nevi.
Notes:
- Large calcifying sertoli cell tumours are also described in association Carney complex.[8]
See also
References
- ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 135. ISBN 978-0781765275.
- ↑ 2.0 2.1 URL: http://emedicine.medscape.com/article/1097150-overview. Accessed on: 25 May 2011.
- ↑ Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 554. ISBN 978-1416054542.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 160980
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 605244
- ↑ URL: http://emedicine.medscape.com/article/1119293-overview. Accessed on: 7 January 2011.
- ↑ URL: http://www.merriam-webster.com/medlineplus/ephelides. Accessed on: 8 February 2012.
- ↑ Gourgari, E.; Saloustros, E.; Stratakis, CA. (Aug 2012). "Large-cell calcifying Sertoli cell tumors of the testes in pediatrics.". Curr Opin Pediatr 24 (4): 518-22. doi:10.1097/MOP.0b013e328355a279. PMID 22732638.