Difference between revisions of "Epidermoid cyst of the testis"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Epidermoid cyst of testis -- low mag.jpg | |||
| Width = | |||
| Caption = Epidermoid cyst of testis. [[H&E stain]]. (WC) | |||
| Synonyms = | |||
| Micro = unilocular cyst lined by squamous epithelium without significant nuclear atypia, no [[GCNIS]] (ITGCN) | |||
| Subtypes = | |||
| LMDDx = [[teratoma]], [[mixed germ cell tumour]], [[immature teratoma]], [[dermoid cyst]] of testis (subtype of teratoma) | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = unilocular cyst containing keratineous material with a laminated appearance | |||
| Grossing = [[orchiectomy grossing]] | |||
| Site = [[testis]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = testicular mass | |||
| Symptoms = typically asymptomatic | |||
| Prevalence = rare (1-2% of testicular masses) | |||
| Bloodwork = normal (beta-hCG, AFP, LDH) | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = other testicular mass - [[germ cell tumours]], abscess | |||
| Tx = excision to exclude a malignant tumour/treat symptoms | |||
}} | |||
'''Epidermoid cyst of the testis''' is a rare benign lesion of the [[testis]]. It is important to differentiate it from a testicular [[teratoma]]. | '''Epidermoid cyst of the testis''' is a rare benign lesion of the [[testis]]. It is important to differentiate it from a testicular [[teratoma]]. | ||
==General== | ==General== | ||
*Rare. | *Rare. | ||
*Benign. | |||
*1-2% of testicular tumours.<ref name=pmid15486244>{{Cite journal | last1 = Loya | first1 = AG. | last2 = Said | first2 = JW. | last3 = Grant | first3 = EG. | title = Epidermoid cyst of the testis: radiologic-pathologic correlation. | journal = Radiographics | volume = 24 Suppl 1 | issue = | pages = S243-6 | month = Oct | year = 2004 | doi = 10.1148/rg.24si035223 | PMID = 15486244 }}</ref> | |||
*Typical age: teens to thirties (range: 3-77).<ref name=pmid15486244/> | |||
Clinical: | |||
*Asymptomatic mass (typical).<ref name=pmid15486244/> | |||
==Gross== | ==Gross== | ||
Features:<ref name=pmid22458906>{{Cite journal | last1 = Ye | first1 = H. | last2 = Ulbright | first2 = TM. | title = Difficult differential diagnoses in testicular pathology. | journal = Arch Pathol Lab Med | volume = 136 | issue = 4 | pages = 435-46 | month = Apr | year = 2012 | doi = 10.5858/arpa.2011-0475-RA | PMID = 22458906 }}</ref> | Features:<ref name=pmid22458906>{{Cite journal | last1 = Ye | first1 = H. | last2 = Ulbright | first2 = TM. | title = Difficult differential diagnoses in testicular pathology. | journal = Arch Pathol Lab Med | volume = 136 | issue = 4 | pages = 435-46 | month = Apr | year = 2012 | doi = 10.5858/arpa.2011-0475-RA | PMID = 22458906 }}</ref> | ||
| Line 14: | Line 50: | ||
==Microscopic== | ==Microscopic== | ||
Features:<ref name=pmid22458906/> | Features:<ref name=pmid22458906/> | ||
*Cyst lined by squamous epithelium | *Cyst lined by squamous epithelium without significant [[nuclear atypia]]. | ||
*'''No''' adnexal structures. | *'''No''' adnexal structures. | ||
*'''No''' [[ | *'''No''' [[germ cell neoplasia in situ]] (GCNIS) in the adjacent seminiferous tubules. | ||
*'''No''' nuclear atypia. | *'''No''' nuclear atypia. | ||
Notes: | |||
*Surround testis usually within normal limits. | |||
*Granulomas may be seen in the context of cyst rupture. | |||
DDx: | DDx: | ||
*[[Dermoid cyst]] - adnexal structures, e.g. sweat glands, hair follicules. | *[[Dermoid cyst]] - adnexal structures, e.g. sweat glands, hair follicules. | ||
*[[Teratoma]] - nuclear atypia, multilocular, | *[[Teratoma]] - nuclear atypia, multilocular, mesenchymal elements. | ||
*[[Mixed germ cell tumour]]. | *[[Mixed germ cell tumour]]. | ||
===Images=== | |||
<gallery> | |||
Image: Epidermoid cyst of testis -- very low mag.jpg | ECT - very low mag. | |||
Image: Epidermoid cyst of testis -- low mag.jpg | ECT - low mag. | |||
Image: Epidermoid cyst of testis -- intermed mag.jpg | ECT - intermed. mag. | |||
Image: Epidermoid cyst of testis -- high mag.jpg | ECT - high mag. | |||
</gallery> | |||
==See also== | ==See also== | ||
*[[Testis]]. | *[[Testis]]. | ||
*[[Epidermal inclusion cyst]]. | |||
==References== | ==References== | ||
{{Reflist| | {{Reflist|2}} | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Testis]] | [[Category:Testis]] | ||
Latest revision as of 23:42, 15 March 2016
| Epidermoid cyst of the testis | |
|---|---|
| Diagnosis in short | |
 Epidermoid cyst of testis. H&E stain. (WC) | |
|
| |
| LM | unilocular cyst lined by squamous epithelium without significant nuclear atypia, no GCNIS (ITGCN) |
| LM DDx | teratoma, mixed germ cell tumour, immature teratoma, dermoid cyst of testis (subtype of teratoma) |
| Gross | unilocular cyst containing keratineous material with a laminated appearance |
| Grossing notes | orchiectomy grossing |
| Site | testis |
|
| |
| Signs | testicular mass |
| Symptoms | typically asymptomatic |
| Prevalence | rare (1-2% of testicular masses) |
| Blood work | normal (beta-hCG, AFP, LDH) |
| Prognosis | benign |
| Clin. DDx | other testicular mass - germ cell tumours, abscess |
| Treatment | excision to exclude a malignant tumour/treat symptoms |
Epidermoid cyst of the testis is a rare benign lesion of the testis. It is important to differentiate it from a testicular teratoma.
General
Clinical:
- Asymptomatic mass (typical).[1]
Gross
Features:[2]
- Unilocular cyst containing keratineous material with a laminated appearance.
Notes:
- Teratomas are usually multilocular.
- Presence of hair suggests a dermoid cyst.
Microscopic
Features:[2]
- Cyst lined by squamous epithelium without significant nuclear atypia.
- No adnexal structures.
- No germ cell neoplasia in situ (GCNIS) in the adjacent seminiferous tubules.
- No nuclear atypia.
Notes:
- Surround testis usually within normal limits.
- Granulomas may be seen in the context of cyst rupture.
DDx:
- Dermoid cyst - adnexal structures, e.g. sweat glands, hair follicules.
- Teratoma - nuclear atypia, multilocular, mesenchymal elements.
- Mixed germ cell tumour.
Images
ECT - very low mag.
ECT - low mag.
ECT - intermed. mag.
ECT - high mag.
See also
References
- ↑ 1.0 1.1 1.2 Loya, AG.; Said, JW.; Grant, EG. (Oct 2004). "Epidermoid cyst of the testis: radiologic-pathologic correlation.". Radiographics 24 Suppl 1: S243-6. doi:10.1148/rg.24si035223. PMID 15486244.
- ↑ 2.0 2.1 Ye, H.; Ulbright, TM. (Apr 2012). "Difficult differential diagnoses in testicular pathology.". Arch Pathol Lab Med 136 (4): 435-46. doi:10.5858/arpa.2011-0475-RA. PMID 22458906.