Difference between revisions of "Serous borderline tumour"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Serous borderline tumour with micropapillary pattern -- intermed mag.jpg | |||
| Width = | |||
| Caption = Serous borderline tumour with a micropapillary pattern. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = cuboidal to columnar epithelium with mild to moderate atypia, no invasion (see below), "sparse" mitoses ,+/-[[psammoma bodies]], +/-micropapillary architecture (often described as a ''medusa head'' pattern) | |||
| Subtypes = serous borderline tumour (SBT) with micropapillary pattern, typical SBT ''or'' SBT not otherwise specified | |||
| LMDDx = [[serous cystadenoma of the ovary|serous cystadenoma]], [[serous carcinoma of the ovary]], [[clear cell carcinoma of the ovary]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Staging = | |||
| Site = [[ovary]], [[uterine tube]] - see ''[[ovarian tumours]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = usually benign, need follow-up | |||
| Other = | |||
| ClinDDx = other [[ovarian tumours]] (benign and malignant) | |||
| Tx = excision, follow-up | |||
}} | |||
'''Serous borderline tumour''' is a Muellerian epithelial [[ovarian tumour]] with a behaviour that borders on [[malignant]]. | |||
It is also known as '''serous tumour of low malignant potential''', abbreviated ''SLMP''.<ref name=pmid10836293>{{Cite journal | last1 = Seidman | first1 = JD. | last2 = Kurman | first2 = RJ. | title = Ovarian serous borderline tumors: a critical review of the literature with emphasis on prognostic indicators. | journal = Hum Pathol | volume = 31 | issue = 5 | pages = 539-57 | month = May | year = 2000 | doi = | PMID = 10836293 }}</ref><ref name=pmid10881733>{{Cite journal | last1 = Dietel | first1 = M. | last2 = Hauptmann | first2 = S. | title = Serous tumors of low malignant potential of the ovary. 1. Diagnostic pathology. | journal = Virchows Arch | volume = 436 | issue = 5 | pages = 403-12 | month = May | year = 2000 | doi = | PMID = 10881733 }}</ref> | |||
''Serous ovarian tumour of low malignant potential'' redirects here.<ref name=pmid10881733/> | |||
==General== | |||
*Usually benign. | |||
*Require long term follow-up. | |||
==Microscopic== | |||
Features:<ref name=Ref_GP399>{{Ref GP|399}}</ref> | |||
*Cuboidal to columnar epithelium with mild to moderate atypia. | |||
*Non-invasive. | |||
*"Sparse" mitoses. | |||
*+/-[[Psammoma bodies]]. | |||
*+/-Micropapillary architecture - often described as a ''medusa head'' pattern. | |||
DDx: | |||
*[[Serous carcinoma of the ovary]] - focus a with stromal invasion >5mm (linear measurement) ''or'' > 10 mm<sup>2</sup> (area).<ref name=Ref_GP399>{{Ref GP|399}}</ref> | |||
**Invasive cells are "pink", i.e. have abundant eosinophilic cytoplasm,<ref name=Ref_GP399/>; also, cells usu. large (~2-3x size of non-invasive component), and typically have an enlarged nucleus (~2x non-invasive component). | |||
*[[Clear cell carcinoma of the ovary]] - classically associated with [[endometriosis]], have simpler, smaller papillae without branching. | |||
*[[Serous cystadenoma of the ovary]]. | |||
===Images=== | |||
<gallery> | |||
Image: Serous borderline tumour with micropapillary pattern -- intermed mag.jpg -- very very low mag.jpg | SBTMP - very very low mag. | |||
Image: Serous borderline tumour with micropapillary pattern -- very low mag.jpg | SBTMP - very low mag. | |||
Image: Serous borderline tumour with micropapillary pattern -- low mag.jpg | SBTMP - low mag. | |||
Image: Serous borderline tumour with micropapillary pattern -- intermed mag.jpg | SBTMP - intermed. mag. | |||
Image: Serous borderline tumour with micropapillary pattern -- high mag.jpg | SBTMP - high mag. | |||
Image: Serous borderline tumour with micropapillary pattern - a -- very low mag.jpg | SBTMP - very low mag. | |||
Image: Serous borderline tumour with micropapillary pattern - a -- low mag.jpg | SBTMP - low mag. | |||
Image: Serous borderline tumour with micropapillary pattern - a -- intermed mag.jpg | SBTMP - intermed. mag. | |||
Image: Serous borderline tumour with micropapillary pattern - a -- high mag.jpg | SBTMP - high mag. | |||
Image: Serous borderline tumour with micropapillary pattern - a2 -- high mag.jpg | SBTMP - high mag. | |||
Image: Serous borderline tumour with micropapillary pattern - a3 -- high mag.jpg | SBTMP - high mag. | |||
Image: Serous borderline tumour with micropapillary pattern - a -- very high mag.jpg | SBTMP - very high mag. | |||
</gallery> | |||
====www==== | |||
*[http://pubs.rsna.org/na101/home/literatum/publisher/rsna/journals/content/radiographics/2005/radiographics.2005.25.issue-6/rg.256055015/production/images/medium/g05nv16c4x.jpeg Serous ovarian LMP tumour (radiographics.rsna.org)].<ref name=pmid16284143>{{Cite journal | last1 = Burkholz | first1 = KJ. | last2 = Wood | first2 = BP. | last3 = Zuppan | first3 = C. | title = Best cases from the AFIP: Borderline papillary serous tumor of the right ovary. | journal = Radiographics | volume = 25 | issue = 6 | pages = 1689-92 | month = | year = | doi = 10.1148/rg.256055015 | PMID = 16284143 }}</ref> | |||
===Subclassification=== | |||
Typical subdivided into:<ref name=pmid21917305>{{Cite journal | last1 = Park | first1 = JY. | last2 = Kim | first2 = DY. | last3 = Kim | first3 = JH. | last4 = Kim | first4 = YM. | last5 = Kim | first5 = KR. | last6 = Kim | first6 = YT. | last7 = Nam | first7 = JH. | title = Micropapillary pattern in serous borderline ovarian tumors: does it matter? | journal = Gynecol Oncol | volume = 123 | issue = 3 | pages = 511-6 | month = Dec | year = 2011 | doi = 10.1016/j.ygyno.2011.08.008 | PMID = 21917305 }}</ref> | |||
*Micropapillary serous borderline tumour. | |||
*Typical serous borderline tumour (SBOT). | |||
==Sign out== | |||
<pre> | |||
Cyst and Right Fallopian Tube, Excision: | |||
- SEROUS BORDERLINE TUMOUR with micropapillary architecture, see comment. | |||
- Fallopian tube within normal limits. | |||
- NEGATIVE for evidence of invasion. | |||
Comment: | |||
The lesion appears to be confined to a cystic structure. | |||
</pre> | |||
==See also== | |||
*[[Ovarian tumours]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | |||
[[Category:Ovarian tumours]] | |||
Latest revision as of 11:25, 29 March 2016
| Serous borderline tumour | |
|---|---|
| Diagnosis in short | |
 Serous borderline tumour with a micropapillary pattern. H&E stain. | |
|
| |
| LM | cuboidal to columnar epithelium with mild to moderate atypia, no invasion (see below), "sparse" mitoses ,+/-psammoma bodies, +/-micropapillary architecture (often described as a medusa head pattern) |
| Subtypes | serous borderline tumour (SBT) with micropapillary pattern, typical SBT or SBT not otherwise specified |
| LM DDx | serous cystadenoma, serous carcinoma of the ovary, clear cell carcinoma of the ovary |
| Site | ovary, uterine tube - see ovarian tumours |
|
| |
| Prevalence | uncommon |
| Prognosis | usually benign, need follow-up |
| Clin. DDx | other ovarian tumours (benign and malignant) |
| Treatment | excision, follow-up |
Serous borderline tumour is a Muellerian epithelial ovarian tumour with a behaviour that borders on malignant.
It is also known as serous tumour of low malignant potential, abbreviated SLMP.[1][2]
Serous ovarian tumour of low malignant potential redirects here.[2]
General
- Usually benign.
- Require long term follow-up.
Microscopic
Features:[3]
- Cuboidal to columnar epithelium with mild to moderate atypia.
- Non-invasive.
- "Sparse" mitoses.
- +/-Psammoma bodies.
- +/-Micropapillary architecture - often described as a medusa head pattern.
DDx:
- Serous carcinoma of the ovary - focus a with stromal invasion >5mm (linear measurement) or > 10 mm2 (area).[3]
- Invasive cells are "pink", i.e. have abundant eosinophilic cytoplasm,[3]; also, cells usu. large (~2-3x size of non-invasive component), and typically have an enlarged nucleus (~2x non-invasive component).
- Clear cell carcinoma of the ovary - classically associated with endometriosis, have simpler, smaller papillae without branching.
- Serous cystadenoma of the ovary.
Images
SBTMP - very very low mag.
SBTMP - very low mag.
SBTMP - low mag.
SBTMP - intermed. mag.
SBTMP - high mag.
SBTMP - very low mag.
SBTMP - low mag.
SBTMP - intermed. mag.
SBTMP - high mag.
SBTMP - high mag.
SBTMP - high mag.
SBTMP - very high mag.
www
Subclassification
Typical subdivided into:[5]
- Micropapillary serous borderline tumour.
- Typical serous borderline tumour (SBOT).
Sign out
Cyst and Right Fallopian Tube, Excision: - SEROUS BORDERLINE TUMOUR with micropapillary architecture, see comment. - Fallopian tube within normal limits. - NEGATIVE for evidence of invasion. Comment: The lesion appears to be confined to a cystic structure.
See also
References
- ↑ Seidman, JD.; Kurman, RJ. (May 2000). "Ovarian serous borderline tumors: a critical review of the literature with emphasis on prognostic indicators.". Hum Pathol 31 (5): 539-57. PMID 10836293.
- ↑ 2.0 2.1 Dietel, M.; Hauptmann, S. (May 2000). "Serous tumors of low malignant potential of the ovary. 1. Diagnostic pathology.". Virchows Arch 436 (5): 403-12. PMID 10881733.
- ↑ 3.0 3.1 3.2 Nucci, Marisa R.; Oliva, Esther (2009). Gynecologic Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 399. ISBN 978-0443069208.
- ↑ Burkholz, KJ.; Wood, BP.; Zuppan, C.. "Best cases from the AFIP: Borderline papillary serous tumor of the right ovary.". Radiographics 25 (6): 1689-92. doi:10.1148/rg.256055015. PMID 16284143.
- ↑ Park, JY.; Kim, DY.; Kim, JH.; Kim, YM.; Kim, KR.; Kim, YT.; Nam, JH. (Dec 2011). "Micropapillary pattern in serous borderline ovarian tumors: does it matter?". Gynecol Oncol 123 (3): 511-6. doi:10.1016/j.ygyno.2011.08.008. PMID 21917305.