Difference between revisions of "Lymphocytic interstitial pneumonia"
Jump to navigation
Jump to search
(+infobox) |
|||
| Line 1: | Line 1: | ||
{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = | |||
| Width = | |||
| Caption = | |||
| Synonyms = | |||
| Micro = small mature lymphocytes in the interstitium of the lung, plasma cells, +/-lymphoid follicles | |||
| Subtypes = | |||
| LMDDx = [[lymphoma]], follicular bronchitis/bronchiolitis, nodular lymphoid hyperplasia | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Staging = | |||
| Site = [[lung]] - see ''[[diffuse lung diseases]]'' | |||
| Assdx = autoimmune disorders ([[rheumatoid arthritis]], [[pernicious anemia]], [[Sjoegren syndrome]]), viral infections ([[HIV]], [[EBV]], human T-cell leukemia virus (HTLV) type 1) | |||
| Syndromes = | |||
| Clinicalhx = dependent on underlying cause - see ''associated diagnoses'' | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = rare | |||
| Bloodwork = | |||
| Rads = basilar predominance, increased interstitial markings | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Lymphocytic interstitial pneumonia''' (abbreviated '''LIP'''), also known as '''lymphoid interstitial pneumonia''' and '''lymphocytic interstitial pneumonitis''', is an uncommon [[diffuse lung disease]]. | '''Lymphocytic interstitial pneumonia''' (abbreviated '''LIP'''), also known as '''lymphoid interstitial pneumonia''' and '''lymphocytic interstitial pneumonitis''', is an uncommon [[diffuse lung disease]]. | ||
Revision as of 16:45, 6 April 2016
| Lymphocytic interstitial pneumonia | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | small mature lymphocytes in the interstitium of the lung, plasma cells, +/-lymphoid follicles |
| LM DDx | lymphoma, follicular bronchitis/bronchiolitis, nodular lymphoid hyperplasia |
| Site | lung - see diffuse lung diseases |
|
| |
| Associated Dx | autoimmune disorders (rheumatoid arthritis, pernicious anemia, Sjoegren syndrome), viral infections (HIV, EBV, human T-cell leukemia virus (HTLV) type 1) |
| Clinical history | dependent on underlying cause - see associated diagnoses |
| Prevalence | rare |
| Radiology | basilar predominance, increased interstitial markings |
Lymphocytic interstitial pneumonia (abbreviated LIP), also known as lymphoid interstitial pneumonia and lymphocytic interstitial pneumonitis, is an uncommon diffuse lung disease.
General
- Associated with autoimmune disorders (rheumatoid arthritis, pernicious anemia, Sjoegren syndrome)[1] and immunodeficiency.[2]
- Associated with viral infections (HIV, EBV, human T-cell leukemia virus (HTLV) type 1).
- Considered an AIDS-defining diagnosis.[3]
Gross
- Location: basilar predominance.
- Increased interstitial markings.
Microscopic
Features:[4]
- Small mature lymphocytes (usually B cells)[5] in the interstitium of the lung.
- Plasma cells.
- +/-Lymphoid follicles.
Negatives:
- No vasculitis.
- No necrosis.
DDx:
- Lymphoma.
- Follicular bronchitis/bronchiolitis.
- Nodular lymphoid hyperplasia.
- This is determined in part by radiology; it has nodules radiographically.
Images
www:
Stains
To exclude infection:[6]
- GMS stain -ve.
- Ziehl-Neelsen stain -ve.
IHC
- May be done to exclude lymphoma.
See also
References
- ↑ URL: http://emedicine.medscape.com/article/299643-overview. Accessed on: 2 June 2010.
- ↑ Nicholson AG (August 2001). "Lymphocytic interstitial pneumonia and other lymphoproliferative disorders in the lung". Semin Respir Crit Care Med 22 (4): 409–22. doi:10.1055/s-2001-17384. PMID 16088689.
- ↑ Turner, BJ.; Eppes, S.; McKee, LJ.; Cosler, L.; Markson, LE. (Jan 1995). "A population-based comparison of the clinical course of children and adults with AIDS.". AIDS 9 (1): 65-72. PMID 7893443.
- ↑ URL: http://emedicine.medscape.com/article/299643-diagnosis. Accessed on: 2 June 2010.
- ↑ AFIP atlas of nontumour pathology. 2002. Vo. 2. P.265. ISBN 1-881041-79-4.
- ↑ URL: http://path.upmc.edu/cases/case176/dx.html. Accessed on: 8 January 2012.