Difference between revisions of "Mammary myofibroblastoma"

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#redirect [[Breast_pathology#Mammary_myofibroblastoma]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Mammary myofibroblastoma - extra - very high mag.jpg
| Width      =
| Caption    = Mammary myofibroblastoma. [[H&E stain]].
| Synonyms  = myofibroblastoma of the breast, breast myofibroblastoma
| Micro      = well-circumscribed lesion, wpindle cells without nuclear atypia arranged in fascicles, interspersed thick bundles of collagen.
| Subtypes  =
| LMDDx      = [[metaplastic breast carcinoma]], [[fibromatosis]], [[leiomyoma]] of the breast, [[nodular fasciitis]], [[phyllodes tumour]], [[spindle cell lipoma]]
| Stains    =
| IHC        = CD34 +ve, SMA +ve, desmin, +ve, vimentin +ve, S-100 -ve, beta-catenin -ve
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[breast]]
| Assdx      =
| Syndromes  =
| Clinicalhx = postmenopausal female or older male
| Signs      =
| Symptoms  =
| Prevalence = rare
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign
| Other      =
| ClinDDx    =
| Tx        = excision
}}
'''Mammary myofibroblastoma''', also '''myofibroblastoma of the breast''', is a rare benign pathology of the [[breast]].


==General==
*Rare.
*Excision = cure.
*Postmenopausal females and older males.<ref name=pmid18723968>{{Cite journal  | last1 = Qureshi | first1 = A. | last2 = Kayani | first2 = N. | title = Myofibroblastoma of breast. | journal = Indian J Pathol Microbiol | volume = 51 | issue = 3 | pages = 395-6 | month =  | year =  | doi =  | PMID = 18723968 }}</ref><ref name=pmid22096693>{{Cite journal  | last1 = Mele | first1 = M. | last2 = Jensen | first2 = V. | last3 = Wronecki | first3 = A. | last4 = Lelkaitis | first4 = G. | title = Myofibroblastoma of the breast: Case report and literature review. | journal = Int J Surg Case Rep | volume = 2 | issue = 6 | pages = 93-6 | month =  | year = 2011 | doi = 10.1016/j.ijscr.2011.02.006 | PMID = 22096693 | PMC = 3199680 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199680/}}</ref>
Note:
*In extra-mammary sites the tumour is known as a ''mammary-type myofibroblastoma'' may immunohistochemically and histomorphologically overlap with [[spindle cell lipoma]].<ref name=pmid11474286>{{Cite journal  | last1 = McMenamin | first1 = ME. | last2 = Fletcher | first2 = CD. | title = Mammary-type myofibroblastoma of soft tissue: a tumor closely related to spindle cell lipoma. | journal = Am J Surg Pathol | volume = 25 | issue = 8 | pages = 1022-9 | month = Aug | year = 2001 | doi =  | PMID = 11474286 }}</ref>
==Microscopic==
Features:<ref name=Ref_BP131>{{Ref BP|131}}</ref>
*Well-circumscribed lesion.
*Spindle cells without nuclear atypia arranged in fascicles.
*Interspersed thick bundles of collagen.
Notes:
*No calcifications.
*No necrosis.
*No hemorrhage.
DDx:
*[[Metaplastic breast carcinoma]].<ref name=pmid24298520/>
*[[Fibromatosis]].
*[[Leiomyoma]] of the breast.
*[[Nodular fasciitis]].
*[[Phyllodes tumour]].
*[[Spindle cell lipoma]].
===Images===
<gallery>
Image:Mammary_myofibroblastoma_-_low_mag.jpg | Mammary myofibroblastoma - low mag. (WC/Nephron)
Image:Mammary_myofibroblastoma_-_intermed_mag.jpg | Mammary myofibroblastoma - intermed. mag. (WC/Nephron)
Image:Mammary_myofibroblastoma_-_high_mag.jpg | Mammary myofibroblastoma - high mag. (WC/Nephron)
</gallery>
www:
*[http://path.upmc.edu/cases/case249.html Mammary myofibroblastoma - several images (upmc.edu)].
==IHC==
Features:<ref name=pmid22096693>{{Cite journal  | last1 = Mele | first1 = M. | last2 = Jensen | first2 = V. | last3 = Wronecki | first3 = A. | last4 = Lelkaitis | first4 = G. | title = Myofibroblastoma of the breast: Case report and literature review. | journal = Int J Surg Case Rep | volume = 2 | issue = 6 | pages = 93-6 | month =  | year = 2011 | doi = 10.1016/j.ijscr.2011.02.006 | PMID = 22096693 | PMC = 3199680 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199680/}}</ref>
*CD34 +ve.<ref name=pmid11474286/>
*Desmin +ve.<ref name=pmid11474286/>
*Actin +ve.
*Vimentin +ve.
*SMA +ve.<ref name=pmid24466766/>
Others:
*S-100 -ve.<ref name=pmid24298520/>
*Beta-catenin -ve.{{fact}}
*H-caldesmon -ve.<ref name=pmid24466766>{{Cite journal  | last1 = Mnif | first1 = H. | last2 = Charfi | first2 = S. | last3 = Abid | first3 = N. | last4 = Sallemi-Boudawara | first4 = T. | title = Mammary myofibroblastoma with leiomyomatous differentiation: case report and literature review. | journal = Pathologica | volume = 105 | issue = 4 | pages = 142-5 | month = Aug | year = 2013 | doi =  | PMID = 24466766 }}</ref>{{fact}}
*CK7 -ve.<ref name=pmid24298520>{{Cite journal  | last1 = Shivali | first1 = B. | last2 = S | first2 = K. | last3 = Chandramouleeswari | first3 = K. | last4 = Anita | first4 = S. | title = Myofibroblastoma breast with unusual morphological features. Cytohistopathogical diagnostic pitfalls and role of immunohistochemistry-review of literature. | journal = J Clin Diagn Res | volume = 7 | issue = 10 | pages = 2323-5 | month = Oct | year = 2013 | doi = 10.7860/JCDR/2013/5281.3515 | PMID = 24298520 }}</ref>
*HMCK -ve.<ref name=pmid24298520/>
==See also==
*[[Breast pathology]].
==References==
{{Reflist|2}}
[[Category:Breast pathology]]
[[Category:Diagnosis]]
[[Category:Diagnosis]]

Latest revision as of 22:55, 1 May 2016

Mammary myofibroblastoma
Diagnosis in short

Mammary myofibroblastoma. H&E stain.
Synonyms myofibroblastoma of the breast, breast myofibroblastoma
LM well-circumscribed lesion, wpindle cells without nuclear atypia arranged in fascicles, interspersed thick bundles of collagen.
LM DDx metaplastic breast carcinoma, fibromatosis, leiomyoma of the breast, nodular fasciitis, phyllodes tumour, spindle cell lipoma
IHC CD34 +ve, SMA +ve, desmin, +ve, vimentin +ve, S-100 -ve, beta-catenin -ve
Site breast
Clinical history postmenopausal female or older male
Prevalence rare
Prognosis benign
Treatment excision

Mammary myofibroblastoma, also myofibroblastoma of the breast, is a rare benign pathology of the breast.

General

  • Rare.
  • Excision = cure.
  • Postmenopausal females and older males.[1][2]

Note:

  • In extra-mammary sites the tumour is known as a mammary-type myofibroblastoma may immunohistochemically and histomorphologically overlap with spindle cell lipoma.[3]

Microscopic

Features:[4]

  • Well-circumscribed lesion.
  • Spindle cells without nuclear atypia arranged in fascicles.
  • Interspersed thick bundles of collagen.

Notes:

  • No calcifications.
  • No necrosis.
  • No hemorrhage.

DDx:

Images

  • Mammary myofibroblastoma - low mag. (WC/Nephron)

  • Mammary myofibroblastoma - intermed. mag. (WC/Nephron)

  • Mammary myofibroblastoma - high mag. (WC/Nephron)

www:

IHC

Features:[2]

  • CD34 +ve.[3]
  • Desmin +ve.[3]
  • Actin +ve.
  • Vimentin +ve.
  • SMA +ve.[6]

Others:

See also

References

  1. ↑ Qureshi, A.; Kayani, N.. "Myofibroblastoma of breast.". Indian J Pathol Microbiol 51 (3): 395-6. PMID 18723968.
  2. ↑ 2.0 2.1 Mele, M.; Jensen, V.; Wronecki, A.; Lelkaitis, G. (2011). "Myofibroblastoma of the breast: Case report and literature review.". Int J Surg Case Rep 2 (6): 93-6. doi:10.1016/j.ijscr.2011.02.006. PMC 3199680. PMID 22096693. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199680/.
  3. ↑ 3.0 3.1 3.2 McMenamin, ME.; Fletcher, CD. (Aug 2001). "Mammary-type myofibroblastoma of soft tissue: a tumor closely related to spindle cell lipoma.". Am J Surg Pathol 25 (8): 1022-9. PMID 11474286.
  4. ↑ O'Malley, Frances P.; Pinder, Sarah E. (2006). Breast Pathology: A Volume in Foundations in Diagnostic Pathology series (1st ed.). Churchill Livingstone. pp. 131. ISBN 978-0443066801.
  5. ↑ 5.0 5.1 5.2 5.3 Shivali, B.; S, K.; Chandramouleeswari, K.; Anita, S. (Oct 2013). "Myofibroblastoma breast with unusual morphological features. Cytohistopathogical diagnostic pitfalls and role of immunohistochemistry-review of literature.". J Clin Diagn Res 7 (10): 2323-5. doi:10.7860/JCDR/2013/5281.3515. PMID 24298520.
  6. ↑ 6.0 6.1 Mnif, H.; Charfi, S.; Abid, N.; Sallemi-Boudawara, T. (Aug 2013). "Mammary myofibroblastoma with leiomyomatous differentiation: case report and literature review.". Pathologica 105 (4): 142-5. PMID 24466766.
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