Difference between revisions of "Astrocytoma"
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** It is likely that suggests that in the upcoming WHO classification gliomatosis is no longer a separate glioma entity.<ref>{{Cite journal | last1 = Herrlinger | first1 = U. | last2 = Jones | first2 = DT. | last3 = Glas | first3 = M. | last4 = Hattingen | first4 = E. | last5 = Gramatzki | first5 = D. | last6 = Stuplich | first6 = M. | last7 = Felsberg | first7 = J. | last8 = Bähr | first8 = O. | last9 = Gielen | first9 = GH. | title = Gliomatosis cerebri: no evidence for a separate brain tumor entity. | journal = Acta Neuropathol | volume = | issue = | pages = | month = Oct | year = 2015 | doi = 10.1007/s00401-015-1495-z | PMID = 26493382 }}</ref> | ** It is likely that suggests that in the upcoming WHO classification gliomatosis is no longer a separate glioma entity.<ref>{{Cite journal | last1 = Herrlinger | first1 = U. | last2 = Jones | first2 = DT. | last3 = Glas | first3 = M. | last4 = Hattingen | first4 = E. | last5 = Gramatzki | first5 = D. | last6 = Stuplich | first6 = M. | last7 = Felsberg | first7 = J. | last8 = Bähr | first8 = O. | last9 = Gielen | first9 = GH. | title = Gliomatosis cerebri: no evidence for a separate brain tumor entity. | journal = Acta Neuropathol | volume = | issue = | pages = | month = Oct | year = 2015 | doi = 10.1007/s00401-015-1495-z | PMID = 26493382 }}</ref> | ||
==H3 | ==Diffuse midline glioma, H3 K27M mutant== | ||
* High-grade astrocytic neoplasm associated with midline structures | * High-grade astrocytic neoplasm associated with midline structures (thalamus, brain stem, spinal cord). | ||
* Mostly in children and adolescents | * Mostly in children and adolescents. | ||
* Includes diffuse intrinsic pontine gliomas (DPIG) | * Includes diffuse intrinsic pontine gliomas (DPIG). | ||
* | * Newly defined entity since WHO 2016 classification.<ref>{{Cite journal | last1 = Louis | first1 = DN. | last2 = Perry | first2 = A. | last3 = Reifenberger | first3 = G. | last4 = von Deimling | first4 = A. | last5 = Figarella-Branger | first5 = D. | last6 = Cavenee | first6 = WK. | last7 = Ohgaki | first7 = H. | last8 = Wiestler | first8 = OD. | last9 = Kleihues | first9 = P. | title = The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. | journal = Acta Neuropathol | volume = 131 | issue = 6 | pages = 803-20 | month = Jun | year = 2016 | doi = 10.1007/s00401-016-1545-1 | PMID = 27157931 }}</ref> | ||
* Distinct biological and clinical group with poor prognosis <ref>{{Cite journal | last1 = Khuong-Quang | first1 = DA. | last2 = Buczkowicz | first2 = P. | last3 = Rakopoulos | first3 = P. | last4 = Liu | first4 = XY. | last5 = Fontebasso | first5 = AM. | last6 = Bouffet | first6 = E. | last7 = Bartels | first7 = U. | last8 = Albrecht | first8 = S. | last9 = Schwartzentruber | first9 = J. | title = K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas. | journal = Acta Neuropathol | volume = 124 | issue = 3 | pages = 439-47 | month = Sep | year = 2012 | doi = 10.1007/s00401-012-0998-0 | PMID = 22661320 }}</ref> | * Distinct biological and clinical group with poor prognosis.<ref>{{Cite journal | last1 = Khuong-Quang | first1 = DA. | last2 = Buczkowicz | first2 = P. | last3 = Rakopoulos | first3 = P. | last4 = Liu | first4 = XY. | last5 = Fontebasso | first5 = AM. | last6 = Bouffet | first6 = E. | last7 = Bartels | first7 = U. | last8 = Albrecht | first8 = S. | last9 = Schwartzentruber | first9 = J. | title = K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas. | journal = Acta Neuropathol | volume = 124 | issue = 3 | pages = 439-47 | month = Sep | year = 2012 | doi = 10.1007/s00401-012-0998-0 | PMID = 22661320 }}</ref> | ||
* MRI: May be or be not enhancing. | |||
*HIstologic spectrum ranges from minimal hypercellularity to full-blown glioblastoma. | |||
<gallery> | <gallery> | ||
File:K27M mutant diffuse glioma of the midline.jpg|Nuclear [[H3F3A]] K27M immunostaining in a diffuse glioma of the midline. (WC/jensflorian) | File:K27M mutant diffuse glioma of the midline.jpg|Nuclear [[H3F3A]] K27M immunostaining in a diffuse glioma of the midline. (WC/jensflorian) | ||
Revision as of 14:12, 18 May 2016
An astrocytoma is a neoplasm derived from an astrocyte. Astrocytomas are common. This article is a brief introduction them. An overview of CNS tumours is found in the CNS tumours article.
Overview
| Name | Type | Variants / Patterns | Image |
|---|---|---|---|
| Diffuse Astrocytoma, WHO II | diffuse | protoplasmatic, fibrillar, gemistocytic | |
| Anaplastic Astrocytoma, WHO III | diffuse | gliomatosis cerebri | |
| Glioblastoma, WHO IV | diffuse | small cell, epitheloid/rhabdoid, with PNET componet, with granular cell component, giant cell, gliosarcoma | |
| Pilocytic astrocytoma, WHO I | circumscribed | pilomyxoid astrocytoma, anaplastic pilocytic astrocytoma | |
| Pleomorphic xanthoastrocytoma, WHO II (PXA) | circumscribed | anaplastic PXA | |
| Subependymal giant cell astrocytoma, WHO I (SEGA) | circumscribed | SEGA in tuberous sclerosis |
.jpg)
Common
Pilocytic astrocytoma
- Benign, cystic, infratentorial.
- Classic childhood tumor, surgically resectable.
- Variant: Pilomyxoid astrocytoma
Main article: Pilocytic astrocytoma
Diffuse astrocytoma
- Grade II astrocytic tumors typically seen in adults.
- Usually show progression to glioblastoma.
Main article: Diffuse astrocytoma
Anaplastic astrocytoma
- Grade III astrocytic tumors typically seen in adults.
- Lacks endothelial proliferations and necrosis of glioblastoma.
Main article: Anaplastic astrocytoma
Glioblastoma
- Most common malignant brain tumor peaking around 65 years.
- Prognosis very poor.
- Variant: Giant cell glioblastoma
- Variant: Gliosarcoma
Main article: Glioblastoma
Uncommon
Subependymal giant cell astrocytoma
- Intraventricular benign tumor of adolescents.
- Assoicated with Tuberous sclerosis.
Main article: Subependymal giant cell astrocytoma
Pleomorphic xanthroastrocytoma (PXA)
- Kids & young adults usually with good prognosis.
- Large lipidized cells mimicking a malignant tumor
Main article: Pleomorphic xanthoastrocytoma
Gliomatosis cerebri
- Extensively diffusely growing astrocytic neoplasm.
- Currently considered a rare pattern of diffuse glioma infiltration.
- Introduced in 1938 as a post-mortem diagnosis.[1]
- More than 3 lobes have to be involved, us. bilateral (radiology required).
- biologic behaviour corresponds to WHO III (ICD-O: 9381/3)
- Based on presence / absence of a solid component authors propose two types:[2]
- GC type 1: classic diffuse growth, without IDH1/2 mutation.
- GC type 2: with a solid portion, mostly IDH1 mutant.
- Genetic studies indicate strong overlap with diffuse astrocytic gliomas, oligodendrogliomas and glioblastoma.
- It is likely that suggests that in the upcoming WHO classification gliomatosis is no longer a separate glioma entity.[3]
Diffuse midline glioma, H3 K27M mutant
- High-grade astrocytic neoplasm associated with midline structures (thalamus, brain stem, spinal cord).
- Mostly in children and adolescents.
- Includes diffuse intrinsic pontine gliomas (DPIG).
- Newly defined entity since WHO 2016 classification.[4]
- Distinct biological and clinical group with poor prognosis.[5]
- MRI: May be or be not enhancing.
- HIstologic spectrum ranges from minimal hypercellularity to full-blown glioblastoma.
Nuclear H3F3A K27M immunostaining in a diffuse glioma of the midline. (WC/jensflorian)
Gliosarcoma
General
- Considered to be a variant of glioblastoma by WHO.[6]
- Rare ~ 200 cases reported in the literature.[6]
- Definition: gliosarcoma = glioblastoma + sarcomatous component.[7]
- Usual location (like glioblastoma): temporal lobe.
Microscopic
Features:
- Glioblastoma.
- Sarcomatous component (one of the following):[6][7]
- Fibroblastic.
- Cartilaginous.
- Osseous.
- Smooth muscle.
- Striated muscle.
- Adipocyte.
Images
Gliosarcoma - elastica van Giesson. (WC)
www:
- Gliosarcoma - several images (upmc.edu).
- Gliosarcoma - case 2 - several images (upmc.edu).
- Gliosarcoma - case 3 - several images (upmc.edu).
IHC
Gliosarcoma with smooth muscle component (gliomyosarcoma):[10]
- SMA +ve.
- Factor VIII +ve.
Gliofibroma
- Very rare indolent tumor in children [11]
- Usually not dura-based (DD: Desmoplastic infantile astrocytoma)
- Glial tumor with non-neoplastic fibromatous component.
See also
References
- ↑ SAMUEL NEVIN - GLIOMATOSIS CEREBRI, DOI: http://dx.doi.org/10.1093/brain/61.2.170 170-191 First published online: 1 June 1938
- ↑ Seiz, M.; Tuettenberg, J.; Meyer, J.; Essig, M.; Schmieder, K.; Mawrin, C.; von Deimling, A.; Hartmann, C. (Aug 2010). "Detection of IDH1 mutations in gliomatosis cerebri, but only in tumors with additional solid component: evidence for molecular subtypes.". Acta Neuropathol 120 (2): 261-7. doi:10.1007/s00401-010-0701-2. PMID 20514489.
- ↑ Herrlinger, U.; Jones, DT.; Glas, M.; Hattingen, E.; Gramatzki, D.; Stuplich, M.; Felsberg, J.; Bähr, O. et al. (Oct 2015). "Gliomatosis cerebri: no evidence for a separate brain tumor entity.". Acta Neuropathol. doi:10.1007/s00401-015-1495-z. PMID 26493382.
- ↑ Louis, DN.; Perry, A.; Reifenberger, G.; von Deimling, A.; Figarella-Branger, D.; Cavenee, WK.; Ohgaki, H.; Wiestler, OD. et al. (Jun 2016). "The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.". Acta Neuropathol 131 (6): 803-20. doi:10.1007/s00401-016-1545-1. PMID 27157931.
- ↑ Khuong-Quang, DA.; Buczkowicz, P.; Rakopoulos, P.; Liu, XY.; Fontebasso, AM.; Bouffet, E.; Bartels, U.; Albrecht, S. et al. (Sep 2012). "K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas.". Acta Neuropathol 124 (3): 439-47. doi:10.1007/s00401-012-0998-0. PMID 22661320.
- ↑ 6.0 6.1 6.2 Han SJ, Yang I, Tihan T, Prados MD, Parsa AT (February 2010). "Primary gliosarcoma: key clinical and pathologic distinctions from glioblastoma with implications as a unique oncologic entity". J. Neurooncol. 96 (3): 313–20. doi:10.1007/s11060-009-9973-6. PMC 2808523. PMID 19618114. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808523/.
- ↑ 7.0 7.1 Ayadi L, Charfi S, Khabir A, et al. (March 2010). "[Cerebral gliosarcoma: clinico-pathologic study of 8 cases]" (in French). Tunis Med 88 (3): 142–6. PMID 20415184.
- ↑ Horiguchi, H.; Hirose, T.; Kannuki, S.; Nagahiro, S.; Sano, T. (Aug 1998). "Gliosarcoma: an immunohistochemical, ultrastructural and fluorescence in situ hybridization study.". Pathol Int 48 (8): 595-602. PMID 9736406.
- ↑ URL: http://path.upmc.edu/cases/case361.html. Accessed on: 15 January 2012.
- ↑ Khanna, M.; Siraj, F.; Chopra, P.; Bhalla, S.; Roy, S.. "Gliosarcoma with prominent smooth muscle component (gliomyosarcoma): a report of 10 cases.". Indian J Pathol Microbiol 54 (1): 51-4. doi:10.4103/0377-4929.77324. PMID 21393877.
- ↑ Deb, P.; Sarkar, C.; Garg, A.; Singh, VP.; Kale, SS.; Sharma, MC. (Feb 2006). "Intracranial gliofibroma mimicking a meningioma: a case report and review of literature.". Clin Neurol Neurosurg 108 (2): 178-86. doi:10.1016/j.clineuro.2004.11.021. PMID 16412839.