Difference between revisions of "Canalicular adenoma"

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Canalicular_adenoma_--_high_mag.jpg
| Width      =
| Caption    = Canalicular adenoma. [[H&E stain]].  (WC)
| Synonyms  =
| Micro      = cords of tumour ("canals") with beading (characteristic), cystic spaces/tubules,
intraluminal squamous balls (common)
| Subtypes  =
| LMDDx      =
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Staging    =
| Site      = [[salivary gland]] - usually upper lip or buccal mucosa
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      = mass lesion
| Symptoms  =
| Prevalence = very rare
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  =
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Canalicular adenoma''' is a rare [[salivary gland]] tumour.
'''Canalicular adenoma''' is a rare [[salivary gland]] tumour.


==General==
==General==
*Exclusively oral cavity.
*Exclusively oral cavity.
**80% of lesions on upper lip.
 
Clinical:
*Mass lesion.<ref name=pmid25141970>{{Cite journal  | last1 = Thompson | first1 = LD. | last2 = Bauer | first2 = JL. | last3 = Chiosea | first3 = S. | last4 = McHugh | first4 = JB. | last5 = Seethala | first5 = RR. | last6 = Miettinen | first6 = M. | last7 = Müller | first7 = S. | title = Canalicular adenoma: a clinicopathologic and immunohistochemical analysis of 67 cases with a review of the literature. | journal = Head Neck Pathol | volume = 9 | issue = 2 | pages = 181-95 | month = Jun | year = 2015 | doi = 10.1007/s12105-014-0560-6 | PMID = 25141970 }}</ref>
 
==Gross==
*Classically upper lip - may be buccal mucosa or palate.
 
Note:
*In one large series of 67 cases:<ref name=pmid25141970/>
**Upper lip 69% (47/67).
**Buccal mucosa 25% (17/67).
**Palate 6% (4/67).


==Microscopic==
==Microscopic==
Features:
Features:<ref name=pmid25141970/>
*Channels - "beading of cell".
*Cords of tumour ("canals") with beading - characteristic.
*Mucoid/hemorrhagic stroma.
*Cystic spaces/tubules.
*Intraluminal squamous balls - common (~60% of cases).
*Myxoid/bluish stroma.


DDx:
DDx:
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===Images===
===Images===
*[http://www.webpathology.com/image.asp?n=1&Case=116 Canalicular adenoma - low mag. (webpathology.com)].
<gallery>
*[http://www.webpathology.com/image.asp?case=116&n=2 Canalicular adenoma - high mag. (webpathology.com)].
Image: Canalicular adenoma -- intermed mag.jpg | CA - intermed. mag. (WC)
Image: Canalicular adenoma - alt -- intermed mag.jpg | CA - intermed. mag. (WC)
Image: Canalicular adenoma -- high mag.jpg | CA - high mag. (WC)
Image: Canalicular adenoma -- very high mag.jpg | CA - very high mag. (WC)
Image: Canalicular adenoma - alt -- very high mag.jpg | CA - very high mag. (WC)
</gallery>
====www====
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424207/figure/Fig2/ CA (nih.gov)].<ref name=pmid25141970/>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424207/figure/Fig3/ CA with myxoid stroma (nih.gov)].


==IHC==
==IHC==
*[[p63]] -ve.
Features:<ref name=pmid25141970/>
**Basal cell adenoma p63 +ve.
*[[S-100]] +ve - diffuse and strong.
*[[Pankeratin]] +ve - diffuse and strong.
*GFAP +ve - luminal.
*SOX10 +ve - nuclear.
*p16 +ve - luminal squamous balls.
*CK5/6 +ve - luminal squamous balls.
*p63 -ve.
**Nuclei negative, cytoplasm positive.
**Positive in basal cell adenoma.


==See also==
==See also==

Latest revision as of 21:43, 1 August 2016

Canalicular adenoma
Diagnosis in short

Canalicular adenoma. H&E stain. (WC)
LM

cords of tumour ("canals") with beading (characteristic), cystic spaces/tubules,

intraluminal squamous balls (common)
Site salivary gland - usually upper lip or buccal mucosa
Signs mass lesion
Prevalence very rare

Canalicular adenoma is a rare salivary gland tumour.

General

  • Exclusively oral cavity.

Clinical:

  • Mass lesion.[1]

Gross

  • Classically upper lip - may be buccal mucosa or palate.

Note:

  • In one large series of 67 cases:[1]
    • Upper lip 69% (47/67).
    • Buccal mucosa 25% (17/67).
    • Palate 6% (4/67).

Microscopic

Features:[1]

  • Cords of tumour ("canals") with beading - characteristic.
  • Cystic spaces/tubules.
  • Intraluminal squamous balls - common (~60% of cases).
  • Myxoid/bluish stroma.

DDx:

Images

  • CA - intermed. mag. (WC)

  • CA - intermed. mag. (WC)

  • CA - high mag. (WC)

  • CA - very high mag. (WC)

  • CA - very high mag. (WC)

www

IHC

Features:[1]

  • S-100 +ve - diffuse and strong.
  • Pankeratin +ve - diffuse and strong.
  • GFAP +ve - luminal.
  • SOX10 +ve - nuclear.
  • p16 +ve - luminal squamous balls.
  • CK5/6 +ve - luminal squamous balls.
  • p63 -ve.
    • Nuclei negative, cytoplasm positive.
    • Positive in basal cell adenoma.

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Thompson, LD.; Bauer, JL.; Chiosea, S.; McHugh, JB.; Seethala, RR.; Miettinen, M.; Müller, S. (Jun 2015). "Canalicular adenoma: a clinicopathologic and immunohistochemical analysis of 67 cases with a review of the literature.". Head Neck Pathol 9 (2): 181-95. doi:10.1007/s12105-014-0560-6. PMID 25141970.
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