Difference between revisions of "Thrombotic thrombocytopenic purpura"
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#Fever. | #Fever. | ||
#Thrombocytopenia. | #Thrombocytopenia. | ||
#Microangiopathic hemolytic anemia. | #Microangiopathic hemolytic [[anemia]]. | ||
#*Usu. with schistocytes (fragmented | #*Usu. with schistocytes (fragmented [[RBC]]s).<ref>{{Ref Klatt|65}}</ref> | ||
#Transient neurologic symptoms. | #Transient neurologic symptoms. | ||
#Renal failure. | #Renal failure. | ||
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*[[Vasculitides]]. | *[[Vasculitides]]. | ||
*[[Medical renal diseases]]. | *[[Medical renal diseases]]. | ||
*[[Anemia]]. | |||
==References== | ==References== | ||
Revision as of 11:54, 22 March 2011
Thrombotic thrombocytopenic purpura is a type of thrombotic microangiopathy.
Classic pentad
It was classically described as the pentad of:[1]
- Fever.
- Thrombocytopenia.
- Microangiopathic hemolytic anemia.
- Transient neurologic symptoms.
- Renal failure.
Mnemonic
HUS/TTP is a CRAFTY syndrome:[3]
- CNS symptoms.
- Renal failure.
- Anemia - microangiopathic hemolytic anemia.
- Fever.
- Thrombocytopenia.
- Y - no one knows "Y" it occurs.
Etiology
Deficiency of plasma enzyme ADAMTS13 which may be:[1]
- Inherited.
- Acquired (autoantibodies).
See also
References
- ↑ 1.0 1.1 Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 669. ISBN 978-1416031215.
- ↑ Klatt, Edward C. (2006). Robbins and Cotran Atlas of Pathology (1st ed.). Saunders. pp. 65. ISBN 978-1416002741.
- ↑ URL: http://www.valuemd.com/mnemonics2.php. Accessed on: 8 November 2010.