Difference between revisions of "Tubulocystic carcinoma of the kidney"
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Tubulocystic renal cell carcinoma -- low mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = Tubulocystic renal cell carcinoma. [[H&E stain]]. | ||
| Synonyms = low-grade collecting duct carcinoma, tubulocystic renal cell carcinoma | | Synonyms = low-grade collecting duct carcinoma, tubulocystic renal cell carcinoma | ||
| Micro = cysts of variable size lined by a single layer of epithelium that has a cuboidal, flat, or hobnail morphology, eosinophilic cytoplasm, large nuclei with prominent nucleoli, +/-fibrotic stroma | | Micro = cysts of variable size lined by a single layer of epithelium that has a cuboidal, flat, or [[hobnail morphology]], eosinophilic cytoplasm, large nuclei with prominent nucleoli, +/-fibrotic stroma | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[renal oncocytoma]], [[cystic nephroma]]/[[mixed epithelial and stromal tumour]], [[multilocular cystic renal cell carcinoma]] | | LMDDx = [[papillary renal cell carcinoma]] - especially oncocytic variant, [[renal oncocytoma]], [[cystic nephroma]]/[[mixed epithelial and stromal tumour]], [[multilocular cystic renal cell carcinoma]] | ||
| Stains = | | Stains = | ||
| IHC = CD10 +ve, RCC +ve, vimentin +ve, AMACR +ve | | IHC = CD10 +ve, RCC +ve, vimentin +ve, AMACR +ve | ||
| Line 14: | Line 14: | ||
| IF = | | IF = | ||
| Gross = multicystic lesion (bubble wrap-like appearance) | | Gross = multicystic lesion (bubble wrap-like appearance) | ||
| Grossing = | | Grossing = [[total nephrectomy for tumour grossing]], [[partial nephrectomy grossing]] | ||
| Staging = [[kidney cancer staging]] | |||
| Site = [[kidney]] | | Site = [[kidney]] | ||
| Assdx = | | Assdx = | ||
| Line 31: | Line 32: | ||
}} | }} | ||
'''Tubulocystic carcinoma of the kidney''', abbreviated '''TCCK''', is a very rare [[kidney tumour]]. | '''Tubulocystic carcinoma of the kidney''', abbreviated '''TCCK''', is a very rare [[kidney tumour]]. | ||
In the [[Vancouver classification|Vancouver modification]] of the WHO classification of renal neoplasia, it is refered to as '''tubulocystic renal cell carcinoma''' (abbreviated '''TC-RCC''').<ref name=pmid24025519>{{Cite journal | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | last3 = Eble | first3 = JN. | last4 = Egevad | first4 = L. | last5 = Epstein | first5 = JI. | last6 = Grignon | first6 = D. | last7 = Hes | first7 = O. | last8 = Moch | first8 = H. | last9 = Montironi | first9 = R. | title = The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. | journal = Am J Surg Pathol | volume = 37 | issue = 10 | pages = 1469-89 | month = Oct | year = 2013 | doi = 10.1097/PAS.0b013e318299f2d1 | PMID = 24025519 }}</ref> | |||
It is also known as '''low-grade collecting duct carcinoma'''.<ref name=pmid19011562 >{{Cite journal | last1 = Amin | first1 = MB. | last2 = MacLennan | first2 = GT. | last3 = Gupta | first3 = R. | last4 = Grignon | first4 = D. | last5 = Paraf | first5 = F. | last6 = Vieillefond | first6 = A. | last7 = Paner | first7 = GP. | last8 = Stovsky | first8 = M. | last9 = Young | first9 = AN. | title = Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma. | journal = Am J Surg Pathol | volume = 33 | issue = 3 | pages = 384-92 | month = Mar | year = 2009 | doi = 10.1097/PAS.0b013e3181872d3f | PMID = 19011562 }}</ref> | It is also known as '''low-grade collecting duct carcinoma'''.<ref name=pmid19011562 >{{Cite journal | last1 = Amin | first1 = MB. | last2 = MacLennan | first2 = GT. | last3 = Gupta | first3 = R. | last4 = Grignon | first4 = D. | last5 = Paraf | first5 = F. | last6 = Vieillefond | first6 = A. | last7 = Paner | first7 = GP. | last8 = Stovsky | first8 = M. | last9 = Young | first9 = AN. | title = Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma. | journal = Am J Surg Pathol | volume = 33 | issue = 3 | pages = 384-92 | month = Mar | year = 2009 | doi = 10.1097/PAS.0b013e3181872d3f | PMID = 19011562 }}</ref> | ||
It should '''not''' be confused with ''[[collecting duct carcinoma]]'', a very aggressive [[renal tumours|renal tumour]]. | It should '''not''' be confused with ''[[collecting duct carcinoma]]'', a very aggressive [[renal tumours|renal tumour]]. | ||
==General== | ==General== | ||
*Rare <1% - in a series of 615 cases. | *Rare <1% - in a series of 615 cases. | ||
*Males:Females ~ 7:1.<ref name=pmid19011562/> | *Males:Females ~ 7:1.<ref name=pmid19011562/> | ||
*Prognosis - probably favourable.<ref name=pmid19011562/> | *Prognosis - probably favourable.<ref name=pmid19011562/> | ||
*Thought to be related to [[papillary renal cell carcinoma]].<ref name=pmid19898225>{{Cite journal | last1 = Zhou | first1 = M. | last2 = Yang | first2 = XJ. | last3 = Lopez | first3 = JI. | last4 = Shah | first4 = RB. | last5 = Hes | first5 = O. | last6 = Shen | first6 = SS. | last7 = Li | first7 = R. | last8 = Yang | first8 = Y. | last9 = Lin | first9 = F. | title = Renal tubulocystic carcinoma is closely related to papillary renal cell carcinoma: implications for pathologic classification. | journal = Am J Surg Pathol | volume = 33 | issue = 12 | pages = 1840-9 | month = Dec | year = 2009 | doi = 10.1097/PAS.0b013e3181be22d1 | PMID = 19898225 }}</ref> | |||
==Gross== | ==Gross== | ||
*Bubble wrap-like appearance - due to the cystic nature.<ref name=pmid19011562/> | *Bubble wrap-like appearance - due to the cystic nature.<ref name=pmid19011562/><ref name=pmid17786473>{{Cite journal | last1 = Azoulay | first1 = S. | last2 = Vieillefond | first2 = A. | last3 = Paraf | first3 = F. | last4 = Pasquier | first4 = D. | last5 = Cussenot | first5 = O. | last6 = Callard | first6 = P. | last7 = Sibony | first7 = M. | title = Tubulocystic carcinoma of the kidney: a new entity among renal tumors. | journal = Virchows Arch | volume = 451 | issue = 5 | pages = 905-9 | month = Nov | year = 2007 | doi = 10.1007/s00428-007-0483-7 | PMID = 17786473 }}</ref> | ||
==Microscopic== | ==Microscopic== | ||
Features:.<ref name=pmid19011562/> | Features:.<ref name=pmid19011562/> | ||
*Cysts of variable size lined by a single layer of epithelium that has a: | *Cysts of variable size lined by a single layer of epithelium that has a: | ||
**Cuboidal, flat, or hobnail morphology. | **Cuboidal, flat, or [[hobnail morphology]]. | ||
**Eosinophilic cytoplasm. | **Eosinophilic cytoplasm. | ||
**Large nuclei with prominent nucleoli. | **Large nuclei with prominent nucleoli. | ||
| Line 56: | Line 58: | ||
DDx: | DDx: | ||
*[[Papillary renal cell carcinoma]] (oncocytic variant). | |||
*[[Hereditary leiomyomatosis renal cell carcinoma syndrome associated renal cell carcinoma]]. | |||
*[[Renal oncocytoma]]. | *[[Renal oncocytoma]]. | ||
*[[Cystic nephroma]]/[[Mixed epithelial and stromal tumour]]. | *[[Cystic nephroma]]/[[Mixed epithelial and stromal tumour]]. | ||
*[[Multilocular cystic renal cell carcinoma | *[[Multilocular cystic renal neoplasm of low malignant potential]] (multilocular cystic renal cell carcinoma). | ||
===Images=== | ===Images=== | ||
====Case 1==== | |||
<gallery> | |||
Image: Tubulocystic renal cell carcinoma -- very low mag.jpg | TC-RCC - very low mag. | |||
Image: Tubulocystic renal cell carcinoma -- low mag.jpg | TC-RCC - low mag. | |||
Image: Tubulocystic renal cell carcinoma -- intermed mag.jpg | TC-RCC - intermed. mag. | |||
Image: Tubulocystic renal cell carcinoma -- high mag.jpg | TC-RCC - high mag. | |||
Image: Tubulocystic renal cell carcinoma -- very high mag.jpg | TC-RCC - very high mag. | |||
Image: Tubulocystic renal cell carcinoma - alt -- low mag.jpg | TC-RCC - low mag. | |||
Image: Tubulocystic renal cell carcinoma - alt -- intermed mag.jpg | TC-RCC - intermed. mag. | |||
Image: Tubulocystic renal cell carcinoma - alt -- high mag.jpg | TC-RCC - high mag. | |||
Image: Tubulocystic renal cell carcinoma - alt -- very high mag.jpg | TC-RCC - very high mag. | |||
</gallery> | |||
====Case 2==== | |||
<gallery> | |||
Image: Tubulocystic carcinoma of the kidney -- low mag.jpg | TC - low mag. | |||
Image: Tubulocystic carcinoma of the kidney -- intermed mag.jpg | TC - intermed. mag. | |||
Image: Tubulocystic carcinoma of the kidney -- high mag.jpg | TC - high mag. | |||
Image: Tubulocystic carcinoma of the kidney -- very high mag.jpg | TC - very high mag. | |||
</gallery> | |||
====www==== | |||
*[http://www.nature.com/modpathol/journal/v22/n2s/fig_tab/modpathol200970f14.html#figure-title TCCK - low mag. (nature.com)].<ref name=pmid19494850>{{Cite journal | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | title = Uncommon and recently described renal carcinomas. | journal = Mod Pathol | volume = 22 Suppl 2 | issue = | pages = S2-S23 | month = Jun | year = 2009 | doi = 10.1038/modpathol.2009.70 | PMID = 19494850 }}</ref> | *[http://www.nature.com/modpathol/journal/v22/n2s/fig_tab/modpathol200970f14.html#figure-title TCCK - low mag. (nature.com)].<ref name=pmid19494850>{{Cite journal | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | title = Uncommon and recently described renal carcinomas. | journal = Mod Pathol | volume = 22 Suppl 2 | issue = | pages = S2-S23 | month = Jun | year = 2009 | doi = 10.1038/modpathol.2009.70 | PMID = 19494850 }}</ref> | ||
*[http://www.nature.com/modpathol/journal/v22/n2s/fig_tab/modpathol200970f15.html#figure-title TCCK - intermed. mag. (nature.com)]. | *[http://www.nature.com/modpathol/journal/v22/n2s/fig_tab/modpathol200970f15.html#figure-title TCCK - intermed. mag. (nature.com)]. | ||
| Line 66: | Line 91: | ||
==IHC== | ==IHC== | ||
Features:<ref name=pmid23525677/> | Features:<ref name=pmid23525677>{{Cite journal | last1 = Alexiev | first1 = BA. | last2 = Drachenberg | first2 = CB. | title = Tubulocystic carcinoma of the kidney: a histologic, immunohistochemical, and ultrastructural study. | journal = Virchows Arch | volume = 462 | issue = 5 | pages = 575-81 | month = May | year = 2013 | doi = 10.1007/s00428-013-1398-0 | PMID = 23525677 }}</ref> | ||
*CD10 +ve. | *CD10 +ve. | ||
*RCC +ve. | *RCC +ve. | ||
*Vimentin +ve. | *Vimentin +ve. | ||
*AMACR +ve. | *[[AMACR]] +ve. | ||
*CK7 -ve/+ve (focally in 2/3 tumours<ref name=pmid23157747>{{Cite journal | last1 = Zhang | first1 = SH. | last2 = Shi | first2 = SF. | last3 = Huang | first3 = SF. | last4 = Zhang | first4 = YN. | last5 = Zheng | first5 = YY. | last6 = Chen | first6 = GY. | title = [Clinical and pathologic features of tubulocystic carcinoma of kidney]. | journal = Zhonghua Bing Li Xue Za Zhi | volume = 41 | issue = 8 | pages = 543-6 | month = Aug | year = 2012 | doi = | PMID = 23157747 }}</ref>). | *[[CK7]] -ve/+ve (focally in 2/3 tumours<ref name=pmid23157747>{{Cite journal | last1 = Zhang | first1 = SH. | last2 = Shi | first2 = SF. | last3 = Huang | first3 = SF. | last4 = Zhang | first4 = YN. | last5 = Zheng | first5 = YY. | last6 = Chen | first6 = GY. | title = [Clinical and pathologic features of tubulocystic carcinoma of kidney]. | journal = Zhonghua Bing Li Xue Za Zhi | volume = 41 | issue = 8 | pages = 543-6 | month = Aug | year = 2012 | doi = | PMID = 23157747 }}</ref>). | ||
Notes: | |||
*IHC profile essentially that of [[PaRCC]].{{fact}} | |||
==See also== | ==See also== | ||
Latest revision as of 18:14, 28 February 2017
| Tubulocystic carcinoma of the kidney | |
|---|---|
| Diagnosis in short | |
 Tubulocystic renal cell carcinoma. H&E stain. | |
|
| |
| Synonyms | low-grade collecting duct carcinoma, tubulocystic renal cell carcinoma |
|
| |
| LM | cysts of variable size lined by a single layer of epithelium that has a cuboidal, flat, or hobnail morphology, eosinophilic cytoplasm, large nuclei with prominent nucleoli, +/-fibrotic stroma |
| LM DDx | papillary renal cell carcinoma - especially oncocytic variant, renal oncocytoma, cystic nephroma/mixed epithelial and stromal tumour, multilocular cystic renal cell carcinoma |
| IHC | CD10 +ve, RCC +ve, vimentin +ve, AMACR +ve |
| Gross | multicystic lesion (bubble wrap-like appearance) |
| Grossing notes | total nephrectomy for tumour grossing, partial nephrectomy grossing |
| Staging | kidney cancer staging |
| Site | kidney |
|
| |
| Clinical history | typically male |
| Prevalence | very rare |
| Prognosis | good |
Tubulocystic carcinoma of the kidney, abbreviated TCCK, is a very rare kidney tumour.
In the Vancouver modification of the WHO classification of renal neoplasia, it is refered to as tubulocystic renal cell carcinoma (abbreviated TC-RCC).[1]
It is also known as low-grade collecting duct carcinoma.[2]
It should not be confused with collecting duct carcinoma, a very aggressive renal tumour.
General
- Rare <1% - in a series of 615 cases.
- Males:Females ~ 7:1.[2]
- Prognosis - probably favourable.[2]
- Thought to be related to papillary renal cell carcinoma.[3]
Gross
Microscopic
Features:.[2]
- Cysts of variable size lined by a single layer of epithelium that has a:
- Cuboidal, flat, or hobnail morphology.
- Eosinophilic cytoplasm.
- Large nuclei with prominent nucleoli.
- +/-Fibrotic stroma.
DDx:
- Papillary renal cell carcinoma (oncocytic variant).
- Hereditary leiomyomatosis renal cell carcinoma syndrome associated renal cell carcinoma.
- Renal oncocytoma.
- Cystic nephroma/Mixed epithelial and stromal tumour.
- Multilocular cystic renal neoplasm of low malignant potential (multilocular cystic renal cell carcinoma).
Images
Case 1
TC-RCC - very low mag.
TC-RCC - low mag.
TC-RCC - intermed. mag.
TC-RCC - high mag.
TC-RCC - very high mag.
TC-RCC - low mag.
TC-RCC - intermed. mag.
TC-RCC - high mag.
TC-RCC - very high mag.
Case 2
TC - low mag.
TC - intermed. mag.
TC - high mag.
TC - very high mag.
www
IHC
Features:[6]
Notes:
- IHC profile essentially that of PaRCC.[citation needed]
See also
References
- ↑ Srigley, JR.; Delahunt, B.; Eble, JN.; Egevad, L.; Epstein, JI.; Grignon, D.; Hes, O.; Moch, H. et al. (Oct 2013). "The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia.". Am J Surg Pathol 37 (10): 1469-89. doi:10.1097/PAS.0b013e318299f2d1. PMID 24025519.
- ↑ 2.0 2.1 2.2 2.3 2.4 Amin, MB.; MacLennan, GT.; Gupta, R.; Grignon, D.; Paraf, F.; Vieillefond, A.; Paner, GP.; Stovsky, M. et al. (Mar 2009). "Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma.". Am J Surg Pathol 33 (3): 384-92. doi:10.1097/PAS.0b013e3181872d3f. PMID 19011562.
- ↑ Zhou, M.; Yang, XJ.; Lopez, JI.; Shah, RB.; Hes, O.; Shen, SS.; Li, R.; Yang, Y. et al. (Dec 2009). "Renal tubulocystic carcinoma is closely related to papillary renal cell carcinoma: implications for pathologic classification.". Am J Surg Pathol 33 (12): 1840-9. doi:10.1097/PAS.0b013e3181be22d1. PMID 19898225.
- ↑ Azoulay, S.; Vieillefond, A.; Paraf, F.; Pasquier, D.; Cussenot, O.; Callard, P.; Sibony, M. (Nov 2007). "Tubulocystic carcinoma of the kidney: a new entity among renal tumors.". Virchows Arch 451 (5): 905-9. doi:10.1007/s00428-007-0483-7. PMID 17786473.
- ↑ Srigley, JR.; Delahunt, B. (Jun 2009). "Uncommon and recently described renal carcinomas.". Mod Pathol 22 Suppl 2: S2-S23. doi:10.1038/modpathol.2009.70. PMID 19494850.
- ↑ Alexiev, BA.; Drachenberg, CB. (May 2013). "Tubulocystic carcinoma of the kidney: a histologic, immunohistochemical, and ultrastructural study.". Virchows Arch 462 (5): 575-81. doi:10.1007/s00428-013-1398-0. PMID 23525677.
- ↑ Zhang, SH.; Shi, SF.; Huang, SF.; Zhang, YN.; Zheng, YY.; Chen, GY. (Aug 2012). "[Clinical and pathologic features of tubulocystic carcinoma of kidney].". Zhonghua Bing Li Xue Za Zhi 41 (8): 543-6. PMID 23157747.