Difference between revisions of "Thymic carcinoma"
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'''Thymic carcinoma''' is a malignant tumour of the [[thymus]]. It was previously known as ''thymic tumour type C''. | |||
==General== | |||
*Rare. | |||
*Usually arise ''de novo'', i.e. thymoma is not generally a precursor. | |||
*Risk factors - possibly: [[smoking]], radiation.<ref name=pmid23319214/> | |||
==Microscopic== | |||
Features:<ref name=Ref_WMSP147>{{Ref WMSP|147}}</ref> | |||
*Cytologically malignant - variable morphology. | |||
**[[Squamous cell carcinoma]] is the most common (65-73% of cases<ref name=pmid23319214>{{Cite journal | last1 = Thomas de Montpréville | first1 = V. | last2 = Ghigna | first2 = MR. | last3 = Lacroix | first3 = L. | last4 = Besse | first4 = B. | last5 = Broet | first5 = P. | last6 = Dartevelle | first6 = P. | last7 = Fadel | first7 = E. | last8 = Dorfmuller | first8 = P. | title = Thymic carcinomas: clinicopathologic study of 37 cases from a single institution. | journal = Virchows Arch | volume = 462 | issue = 3 | pages = 307-13 | month = Mar | year = 2013 | doi = 10.1007/s00428-013-1371-y | PMID = 23319214 }}</ref><ref name=pmid23866799>{{Cite journal | last1 = Zhao | first1 = Y. | last2 = Zhao | first2 = H. | last3 = Hu | first3 = D. | last4 = Fan | first4 = L. | last5 = Shi | first5 = J. | last6 = Fang | first6 = W. | title = Surgical treatment and prognosis of thymic squamous cell carcinoma: a retrospective analysis of 105 cases. | journal = Ann Thorac Surg | volume = 96 | issue = 3 | pages = 1019-24 | month = Sep | year = 2013 | doi = 10.1016/j.athoracsur.2013.04.078 | PMID = 23866799 }}</ref>). | |||
*+/-Squamous differentiation. | |||
Notes: | |||
*Staging depends on capsular invasion. | |||
DDx: | |||
*[[Thymoma]]. | |||
*[[Lung cancer|Lung carcinoma]]. | |||
*[[Gastrointestinal stromal tumour]].<ref name=pmid23375402>{{Cite journal | last1 = Rossi | first1 = V. | last2 = Donini | first2 = M. | last3 = Sergio | first3 = P. | last4 = Passalacqua | first4 = R. | last5 = Rossi | first5 = G. | last6 = Buti | first6 = S. | title = When a thymic carcinoma becomes a GIST. | journal = Lung Cancer | volume = 80 | issue = 1 | pages = 106-8 | month = Apr | year = 2013 | doi = 10.1016/j.lungcan.2013.01.003 | PMID = 23375402 }}</ref> | |||
===Images=== | |||
*[http://www.webpathology.com/image.asp?n=1&Case=653 Thymic carcinoma - low mag. (webpathology.com)]. | |||
*[http://www.webpathology.com/image.asp?n=2&Case=653 Thymic carcinoma - high mag. (webpathology.com)]. | |||
*[http://www.webpathology.com/image.asp?n=4&Case=653 Thymic carcinoma - lymphoepithelioma-like - high mag. (webpathology.com)]. | |||
==IHC== | |||
Features:<ref name=Ref_WMSP147>{{Ref WMSP|147}}</ref> | |||
*CD5 +ve (90% of cases<ref name=pmid23319214/>).<ref name=Ref_PBoD708>{{Ref PBoD|708}}</ref> | |||
*CD117 +ve (87% of cases<ref name=pmid23319214/>). | |||
*CD7 +ve. | |||
*[[TTF-1]] -ve. | |||
Note: | |||
*Should stain with [[keratins]]. | |||
==See also== | |||
*[[Thymus]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Haematopathology]] | |||
Latest revision as of 02:54, 20 March 2018
Thymic carcinoma is a malignant tumour of the thymus. It was previously known as thymic tumour type C.
General
- Rare.
- Usually arise de novo, i.e. thymoma is not generally a precursor.
- Risk factors - possibly: smoking, radiation.[1]
Microscopic
Features:[2]
- Cytologically malignant - variable morphology.
- Squamous cell carcinoma is the most common (65-73% of cases[1][3]).
- +/-Squamous differentiation.
Notes:
- Staging depends on capsular invasion.
DDx:
Images
- Thymic carcinoma - low mag. (webpathology.com).
- Thymic carcinoma - high mag. (webpathology.com).
- Thymic carcinoma - lymphoepithelioma-like - high mag. (webpathology.com).
IHC
Features:[2]
Note:
- Should stain with keratins.
See also
References
- ↑ 1.0 1.1 1.2 1.3 Thomas de Montpréville, V.; Ghigna, MR.; Lacroix, L.; Besse, B.; Broet, P.; Dartevelle, P.; Fadel, E.; Dorfmuller, P. (Mar 2013). "Thymic carcinomas: clinicopathologic study of 37 cases from a single institution.". Virchows Arch 462 (3): 307-13. doi:10.1007/s00428-013-1371-y. PMID 23319214.
- ↑ 2.0 2.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 147. ISBN 978-0781765275.
- ↑ Zhao, Y.; Zhao, H.; Hu, D.; Fan, L.; Shi, J.; Fang, W. (Sep 2013). "Surgical treatment and prognosis of thymic squamous cell carcinoma: a retrospective analysis of 105 cases.". Ann Thorac Surg 96 (3): 1019-24. doi:10.1016/j.athoracsur.2013.04.078. PMID 23866799.
- ↑ Rossi, V.; Donini, M.; Sergio, P.; Passalacqua, R.; Rossi, G.; Buti, S. (Apr 2013). "When a thymic carcinoma becomes a GIST.". Lung Cancer 80 (1): 106-8. doi:10.1016/j.lungcan.2013.01.003. PMID 23375402.
- ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 708. ISBN 0-7216-0187-1.