Difference between revisions of "Drug toxicity"
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This article covers a few of the distinctive histomorphologic pattern and links to other articles that deal with specific organ systems. | This article covers a few of the distinctive histomorphologic pattern and links to other articles that deal with specific organ systems. | ||
=General principles= | |||
A drug/toxin reaction should be considered if there is: | |||
# Ingestion/exposure. | |||
# An appropriate temporal relation. | |||
# An empirical correlation between the drug/toxin and the pattern. | |||
#* Worsening with re-challenge. | |||
#* Improvement with removal of exposure. | |||
#* Pathologic pattern matches with toxin. | |||
#* Drug/toxin detected within individual. | |||
=Site specific= | |||
==Liver drug toxicity== | |||
*[[Drug-induced liver disease]]. | |||
==Stomach== | |||
*[[Reactive gastropathy]]. | |||
==Small bowel== | |||
*[[Small bowel diaphragm disease]]. | |||
=Specific drugs= | |||
==Sodium polystyrene sulfonate== | ==Sodium polystyrene sulfonate== | ||
[[AKA]] ''Kayexalate'' | :[[AKA]] ''Kayexalate'' (trade name). | ||
===General=== | ===General=== | ||
*Used to treat hyperkalemia. | *Used to treat hyperkalemia. | ||
| Line 12: | Line 33: | ||
*Can cause focal [[necrosis]]. | *Can cause focal [[necrosis]]. | ||
Image | ====Image==== | ||
<gallery> | |||
Image:Cecal_adenocarcinoma.jpg | Kayexalate crystals and adenocarcinoma. (WC) | |||
</gallery> | |||
==Proton pump inhibitor== | |||
{{Main|Proton pump inhibitor effect}} | |||
==Nonsteroidal anti-inflammatory drugs== | |||
{{Main|Nonsteroidal anti-inflammatory drugs}} | |||
==Oral contraceptive pill== | |||
{{Main|Oral contraceptive pill}} | |||
==Minocycline== | |||
*[[Minocycline associated thyroid pigmentation]]. | |||
==Spironolactone== | |||
*[[Spironolactone bodies]]. | |||
=See also= | |||
*[[ | *[[Basics]]. | ||
=References= | |||
{{Reflist|1}} | {{Reflist|1}} | ||
[[Category:Stuff]] | [[Category:Stuff]] | ||
Latest revision as of 03:20, 22 March 2018
Drug toxicity, also drug reaction, in pathology is often a diagnosis of exclusion. Few drugs leave a distinctive histomorphologic pattern.
This article covers a few of the distinctive histomorphologic pattern and links to other articles that deal with specific organ systems.
General principles
A drug/toxin reaction should be considered if there is:
- Ingestion/exposure.
- An appropriate temporal relation.
- An empirical correlation between the drug/toxin and the pattern.
- Worsening with re-challenge.
- Improvement with removal of exposure.
- Pathologic pattern matches with toxin.
- Drug/toxin detected within individual.
Site specific
Liver drug toxicity
Stomach
Small bowel
Specific drugs
Sodium polystyrene sulfonate
- AKA Kayexalate (trade name).
General
- Used to treat hyperkalemia.
Microscopic
Features:[1]
- Purple blobs on H&E stain - look somewhat like calcium phosphate.
- Can cause focal necrosis.
Image
Kayexalate crystals and adenocarcinoma. (WC)
Proton pump inhibitor
Main article: Proton pump inhibitor effect
Nonsteroidal anti-inflammatory drugs
Main article: Nonsteroidal anti-inflammatory drugs
Oral contraceptive pill
Main article: Oral contraceptive pill
Minocycline
Spironolactone
See also
References
- ↑ Abraham SC, Bhagavan BS, Lee LA, Rashid A, Wu TT (May 2001). "Upper gastrointestinal tract injury in patients receiving kayexalate (sodium polystyrene sulfonate) in sorbitol: clinical, endoscopic, and histopathologic findings". Am. J. Surg. Pathol. 25 (5): 637-44. PMID 11342776. http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0147-5185&volume=25&issue=5&spage=637.