Difference between revisions of "Colitis cystica profunda"

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      =
| Width      =
| Caption    =
| Micro      = mucin filled cysts in submucosa or deeper
| Subtypes  =
| LMDDx      = well-differentiated [[colorectal adenocarcinoma]], [[mucinous adenocarcinoma]]
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[colon]] and [[rectum]], usu. distal
| Assdx      = [[cap polyposis]]
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = very rare (case reports)
| Bloodwork  =
| Rads      =
| Endoscopy  = polypoid lesion(s)
| Prognosis  = good, benign
| Other      =
| ClinDDx    = other [[GI polyps|polypoid lesions]]
}}
'''Colitis cystica profunda''', abbreviated '''CCP''', a very rare [[gastrointestinal pathology]].
'''Colitis cystica profunda''', abbreviated '''CCP''', a very rare [[gastrointestinal pathology]].


==General==
==General==
*Very rare ~ 200 cases reported.<ref name=pmid17891698>{{Cite journal  | last1 = Dolar | first1 = E. | last2 = Kiyici | first2 = M. | last3 = Yilmazlar | first3 = T. | last4 = Gürel | first4 = S. | last5 = Nak | first5 = SG. | last6 = Gülten | first6 = M. | title = Colitis cystica profunda. | journal = Turk J Gastroenterol | volume = 18 | issue = 3 | pages = 206-7 | month = Sep | year = 2007 | doi =  | PMID = 17891698 }}</ref>
*Very rare ~ 200 cases reported.<ref name=pmid17891698>{{Cite journal  | last1 = Dolar | first1 = E. | last2 = Kiyici | first2 = M. | last3 = Yilmazlar | first3 = T. | last4 = Gürel | first4 = S. | last5 = Nak | first5 = SG. | last6 = Gülten | first6 = M. | title = Colitis cystica profunda. | journal = Turk J Gastroenterol | volume = 18 | issue = 3 | pages = 206-7 | month = Sep | year = 2007 | doi =  | PMID = 17891698 }}</ref>
*Benign - may mimic of adenocarcinoma.<ref name=pmid16018526/>
*Benign - may mimic [[adenocarcinoma]].<ref name=pmid16018526/>
**Has been reported in conjunction with [[colonic adenocarcinoma]].<ref>{{Cite journal  | last1 = Mitsunaga | first1 = M. | last2 = Izumi | first2 = M. | last3 = Uchiyama | first3 = T. | last4 = Sawabe | first4 = A. | last5 = Tanida | first5 = E. | last6 = Hosono | first6 = K. | last7 = Abe | first7 = T. | last8 = Shirahama | first8 = K. | last9 = Kanesaki | first9 = A. | title = Colonic adenocarcinoma associated with colitis cystica profunda. | journal = Gastrointest Endosc | volume = 69 | issue = 3 Pt 2 | pages = 759-60; discussion 760-1 | month = Mar | year = 2009 | doi = 10.1016/j.gie.2008.12.240 | PMID = 19251024 }}</ref>
**Has been reported in conjunction with [[colonic adenocarcinoma]].<ref>{{Cite journal  | last1 = Mitsunaga | first1 = M. | last2 = Izumi | first2 = M. | last3 = Uchiyama | first3 = T. | last4 = Sawabe | first4 = A. | last5 = Tanida | first5 = E. | last6 = Hosono | first6 = K. | last7 = Abe | first7 = T. | last8 = Shirahama | first8 = K. | last9 = Kanesaki | first9 = A. | title = Colonic adenocarcinoma associated with colitis cystica profunda. | journal = Gastrointest Endosc | volume = 69 | issue = 3 Pt 2 | pages = 759-60; discussion 760-1 | month = Mar | year = 2009 | doi = 10.1016/j.gie.2008.12.240 | PMID = 19251024 }}</ref>
*The same process in the [[small bowel]] is ''enteritis cystica profunda''.<ref name=pmid17891698/>
*The same process in the [[small bowel]] is ''enteritis cystica profunda''.<ref name=pmid17891698/>
 
*Association with [[cap polyposis]].<ref name=pmid24118052>{{Cite journal  | last1 = Arana | first1 = R. | last2 = Fléjou | first2 = JF. | last3 = Parc | first3 = Y. | last4 = El-Murr | first4 = N. | last5 = Cosnes | first5 = J. | last6 = Svrcek | first6 = M. | title = Cap polyposis and colitis cystica profunda: a rare association. | journal = Histopathology | volume =  | issue =  | pages =  | month = Sep | year = 2013 | doi = 10.1111/his.12292 | PMID = 24118052 }}</ref>
==Gross==
==Gross==
Features:<ref name=pmid18563984>{{Cite journal  | last1 = Higuera Alvarez | first1 = R. | last2 = García | first2 = Jde L. | last3 = San Miguel | first3 = G. | last4 = Castro | first4 = B. | title = [Colitis cystica profunda]. | journal = Rev Esp Enferm Dig | volume = 100 | issue = 4 | pages = 240-2 | month = Apr | year = 2008 | doi =  | PMID = 18563984 }}</ref>
Features:<ref name=pmid18563984>{{Cite journal  | last1 = Higuera Alvarez | first1 = R. | last2 = García | first2 = Jde L. | last3 = San Miguel | first3 = G. | last4 = Castro | first4 = B. | title = [Colitis cystica profunda]. | journal = Rev Esp Enferm Dig | volume = 100 | issue = 4 | pages = 240-2 | month = Apr | year = 2008 | doi =  | PMID = 18563984 }}</ref>
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==Microscopic==
==Microscopic==
Features:
Features:
*Mucin filled cysts in the submucosa.<ref name=pmid16018526/><ref name=pmid18563984/>
*Mucin filled cysts in the submucosa<ref name=pmid16018526/><ref name=pmid18563984/> or deeper.<ref name=pmid21212765/>
*+/-Inflammation.
 
DDx:
*Well-differentiated [[colorectal adenocarcinoma]].<ref name=pmid16018526>{{Cite journal  | last1 = Kayaçetin | first1 = E. | last2 = Kayaçetin | first2 = S. | title = Colitis cystica profunda simulating rectal carcinoma. | journal = Acta Chir Belg | volume = 105 | issue = 3 | pages = 306-8 | month =  | year =  | doi =  | PMID = 16018526 }}</ref>
*+/-Inflammation.
*+/-Inflammation.


DDx:
DDx:
*Well-differentiated [[colorectal adenocarcinoma]].<ref name=pmid16018526>{{Cite journal  | last1 = Kayaçetin | first1 = E. | last2 = Kayaçetin | first2 = S. | title = Colitis cystica profunda simulating rectal carcinoma. | journal = Acta Chir Belg | volume = 105 | issue = 3 | pages = 306-8 | month =  | year =  | doi =  | PMID = 16018526 }}</ref>
*Well-differentiated [[colorectal adenocarcinoma]].<ref name=pmid16018526>{{Cite journal  | last1 = Kayaçetin | first1 = E. | last2 = Kayaçetin | first2 = S. | title = Colitis cystica profunda simulating rectal carcinoma. | journal = Acta Chir Belg | volume = 105 | issue = 3 | pages = 306-8 | month =  | year =  | doi =  | PMID = 16018526 }}</ref>
*Metastatic [[mucinous adenocarcinoma]].


Image:
Image:
*[http://www.nature.com/ajg/journal/v106/n1/fig_tab/ajg2010374f2.html Colitis cystica profunda (nature.com)].<ref name=pmid21212765 >{{Cite journal  | last1 = Qayed | first1 = E. | last2 = Srinivasan | first2 = S. | last3 = Wehbi | first3 = M. | title = A case of colitis cystica profunda in association with diverticulitis. | journal = Am J Gastroenterol | volume = 106 | issue = 1 | pages = 172-3 | month = Jan | year = 2011 | doi = 10.1038/ajg.2010.374 | PMID = 21212765 | URL = http://www.nature.com/ajg/journal/v106/n1/full/ajg2010374a.html }}</ref>


==See also==
==See also==
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==References==
==References==
{{Reflist|1}}
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Gastrointestinal pathology]]
[[Category:Gastrointestinal pathology]]

Latest revision as of 17:11, 5 May 2018

Colitis cystica profunda
Diagnosis in short
LM mucin filled cysts in submucosa or deeper
LM DDx well-differentiated colorectal adenocarcinoma, mucinous adenocarcinoma
Site colon and rectum, usu. distal
Associated Dx cap polyposis
Prevalence very rare (case reports)
Endoscopy polypoid lesion(s)
Prognosis good, benign
Clin. DDx other polypoid lesions

Colitis cystica profunda, abbreviated CCP, a very rare gastrointestinal pathology.

General

Gross

Features:[5]

Microscopic

Features:

  • Mucin filled cysts in the submucosa[2][5] or deeper.[6]
  • +/-Inflammation.

DDx:

Image:

See also

References

  1. ↑ 1.0 1.1 Dolar, E.; Kiyici, M.; Yilmazlar, T.; Gürel, S.; Nak, SG.; Gülten, M. (Sep 2007). "Colitis cystica profunda.". Turk J Gastroenterol 18 (3): 206-7. PMID 17891698.
  2. ↑ 2.0 2.1 2.2 Kayaçetin, E.; Kayaçetin, S.. "Colitis cystica profunda simulating rectal carcinoma.". Acta Chir Belg 105 (3): 306-8. PMID 16018526.
  3. ↑ Mitsunaga, M.; Izumi, M.; Uchiyama, T.; Sawabe, A.; Tanida, E.; Hosono, K.; Abe, T.; Shirahama, K. et al. (Mar 2009). "Colonic adenocarcinoma associated with colitis cystica profunda.". Gastrointest Endosc 69 (3 Pt 2): 759-60; discussion 760-1. doi:10.1016/j.gie.2008.12.240. PMID 19251024.
  4. ↑ Arana, R.; Fléjou, JF.; Parc, Y.; El-Murr, N.; Cosnes, J.; Svrcek, M. (Sep 2013). "Cap polyposis and colitis cystica profunda: a rare association.". Histopathology. doi:10.1111/his.12292. PMID 24118052.
  5. ↑ 5.0 5.1 Higuera Alvarez, R.; García, Jde L.; San Miguel, G.; Castro, B. (Apr 2008). "[Colitis cystica profunda].". Rev Esp Enferm Dig 100 (4): 240-2. PMID 18563984.
  6. ↑ Cite error: Invalid <ref> tag; no text was provided for refs named pmid21212765
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