Difference between revisions of "GATA3"
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m (other tumours - have yet to work out how to convert pmid numbers to wikimedia references) |
m (brenner's tumour and walthard rests) |
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*[[Trophoblastic tumours]] +ve.<ref>{{Cite journal | last1 = Mirkovic | first1 = J. | last2 = Elias | first2 = K. | last3 = Drapkin | first3 = R. | last4 = Barletta | first4 = JA. | last5 = Quade | first5 = B. | last6 = Hirsch | first6 = MS. | title = GATA3 expression in gestational trophoblastic tissues and tumours. | journal = Histopathology | volume = 67 | issue = 5 | pages = 636-44 | month = Nov | year = 2015 | doi = 10.1111/his.12681 | PMID = 25753145 }}</ref> | *[[Trophoblastic tumours]] +ve.<ref>{{Cite journal | last1 = Mirkovic | first1 = J. | last2 = Elias | first2 = K. | last3 = Drapkin | first3 = R. | last4 = Barletta | first4 = JA. | last5 = Quade | first5 = B. | last6 = Hirsch | first6 = MS. | title = GATA3 expression in gestational trophoblastic tissues and tumours. | journal = Histopathology | volume = 67 | issue = 5 | pages = 636-44 | month = Nov | year = 2015 | doi = 10.1111/his.12681 | PMID = 25753145 }}</ref> | ||
*Parathyroid - [[parathyroid hyperplasia]], [[parathyroid adenoma]], [[parathyroid carcinoma]].<ref name=pmid25046229>{{Cite journal | last1 = Ordóñez | first1 = NG. | title = Value of GATA3 immunostaining in the diagnosis of parathyroid tumors. | journal = Appl Immunohistochem Mol Morphol | volume = 22 | issue = 10 | pages = 756-61 | month = | year = | doi = 10.1097/PAI.0000000000000007 | PMID = 25046229 }}</ref> | *Parathyroid - [[parathyroid hyperplasia]], [[parathyroid adenoma]], [[parathyroid carcinoma]].<ref name=pmid25046229>{{Cite journal | last1 = Ordóñez | first1 = NG. | title = Value of GATA3 immunostaining in the diagnosis of parathyroid tumors. | journal = Appl Immunohistochem Mol Morphol | volume = 22 | issue = 10 | pages = 756-61 | month = | year = | doi = 10.1097/PAI.0000000000000007 | PMID = 25046229 }}</ref> | ||
*Salivary gland tumours < | *Salivary gland tumours <ref name=pmid23604756>{{Cite journal | last1 = Schwartz | first1 = LE. | last2 = Begum | first2 = S. | last3 = Westra | first3 = WH. | last4 = Bishop | first4 = JA. | title = GATA3 immunohistochemical expression in salivary gland neoplasms. | journal = Head Neck Pathol | volume = 7 | issue = 4 | pages = 311-5 | month = Dec | year = 2013 | doi = 10.1007/s12105-013-0442-3 | PMID = 23604756 }}</ref> | ||
*Pheochromocytoma (~70%) vs adrenocortical carcinoma (<10%)< | *Pheochromocytoma (~70%) vs adrenocortical carcinoma (<10%)<ref name=pmid2837449>{{Cite journal | last1 = Perrino | first1 = CM. | last2 = Ho | first2 = A. | last3 = Dall | first3 = CP. | last4 = Zynger | first4 = DL. | title = Utility of GATA3 in the differential diagnosis of pheochromocytoma. | journal = Histopathology | volume = 71 | issue = 3 | pages = 475-479 | month = Sep | year = 2017 | doi = 10.1111/his.13229 | PMID = 28374498 }}</ref> | ||
*[[Brenner tumor]]s and [[Walthard nest]]s<ref name=pmid25281026>{{Cite journal | last1 = Roma | first1 = AA. | last2 = Masand | first2 = RP. | title = Ovarian Brenner tumors and Walthard nests: a histologic and immunohistochemical study. | journal = Hum Pathol | volume = 45 | issue = 12 | pages = 2417-22 | month = Dec | year = 2014 | doi = 10.1016/j.humpath.2014.08.003 | PMID = 25281026 }}</ref> | |||
===Images=== | ===Images=== | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444740/figure/F1/ GATA3 nuclear staining - urothelial carcinoma (nih.gov)].<ref name=pmid22982890/> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444740/figure/F1/ GATA3 nuclear staining - urothelial carcinoma (nih.gov)].<ref name=pmid22982890/> | ||
Revision as of 21:17, 13 May 2018
| GATA3 | |
|---|---|
| Immunostain in short | |
 GATA3 staining in benign urothelium. | |
| Similar stains | thrombomodulin |
| Use | bladder versus prostate, bladder versus SCC |
| Subspeciality | Genitourinary pathology, Breast pathology |
| Normal staining pattern | nuclear |
| Positive | urothelial carcinoma, invasive ductal carcinoma of the breast, lobular breast carcinoma |
| Negative | prostatic carcinoma, squamous cell carcinoma of the lung |
GATA3 an immunostain that is increasingly used in genitourinary pathology.
Positive
- Urothelial carcinoma.[1]
- Breast carcinoma - more sensitive than GCDFP-15.[2]
- Chromophobe renal cell carcinoma ~50% of cases.[2]
- Trophoblastic tumours +ve.[4]
- Parathyroid - parathyroid hyperplasia, parathyroid adenoma, parathyroid carcinoma.[5]
- Salivary gland tumours [6]
- Pheochromocytoma (~70%) vs adrenocortical carcinoma (<10%)[7]
- Brenner tumors and Walthard nests[8]
Images
Negative
- Prostate carcinoma (but beware positivity in benign prostate glands treated with radiotherapy)
- Squamous cell carcinoma of the lung.[1]
See also
References
- ↑ 1.0 1.1 1.2 Chang A, Amin A, Gabrielson E, et al. (October 2012). "Utility of GATA3 immunohistochemistry in differentiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine cervix, anus, and lung". Am. J. Surg. Pathol. 36 (10): 1472–6. doi:10.1097/PAS.0b013e318260cde7. PMC 3444740. PMID 22982890. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444740/.
- ↑ 2.0 2.1 Miettinen, M.; McCue, PA.; Sarlomo-Rikala, M.; Rys, J.; Czapiewski, P.; Wazny, K.; Langfort, R.; Waloszczyk, P. et al. (Jan 2014). "GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.". Am J Surg Pathol 38 (1): 13-22. doi:10.1097/PAS.0b013e3182a0218f. PMID 24145643.
- ↑ Ellis, CL.; Chang, AG.; Cimino-Mathews, A.; Argani, P.; Youssef, RF.; Kapur, P.; Montgomery, EA.; Epstein, JI. (Nov 2013). "GATA-3 immunohistochemistry in the differential diagnosis of adenocarcinoma of the urinary bladder.". Am J Surg Pathol 37 (11): 1756-60. doi:10.1097/PAS.0b013e31829cdba7. PMID 24061521.
- ↑ Mirkovic, J.; Elias, K.; Drapkin, R.; Barletta, JA.; Quade, B.; Hirsch, MS. (Nov 2015). "GATA3 expression in gestational trophoblastic tissues and tumours.". Histopathology 67 (5): 636-44. doi:10.1111/his.12681. PMID 25753145.
- ↑ Ordóñez, NG.. "Value of GATA3 immunostaining in the diagnosis of parathyroid tumors.". Appl Immunohistochem Mol Morphol 22 (10): 756-61. doi:10.1097/PAI.0000000000000007. PMID 25046229.
- ↑ Schwartz, LE.; Begum, S.; Westra, WH.; Bishop, JA. (Dec 2013). "GATA3 immunohistochemical expression in salivary gland neoplasms.". Head Neck Pathol 7 (4): 311-5. doi:10.1007/s12105-013-0442-3. PMID 23604756.
- ↑ Perrino, CM.; Ho, A.; Dall, CP.; Zynger, DL. (Sep 2017). "Utility of GATA3 in the differential diagnosis of pheochromocytoma.". Histopathology 71 (3): 475-479. doi:10.1111/his.13229. PMID 28374498.
- ↑ Roma, AA.; Masand, RP. (Dec 2014). "Ovarian Brenner tumors and Walthard nests: a histologic and immunohistochemical study.". Hum Pathol 45 (12): 2417-22. doi:10.1016/j.humpath.2014.08.003. PMID 25281026.