Difference between revisions of "Porocarcinoma"

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[[adenocarcinoma]], [[malignant melanoma]]
[[adenocarcinoma]], [[malignant melanoma]]
| Stains    =
| Stains    =
| IHC        =
| IHC        = [[CD117]] +ve
| EM        =
| EM        =
| Molecular  =
| Molecular  =
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*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595608/figure/f4/?report=objectonly Eccrine porocarcinoma (nih.gov)].<ref name=pmid28954110/>
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595608/figure/f4/?report=objectonly Eccrine porocarcinoma (nih.gov)].<ref name=pmid28954110/>
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884174/figure/F2/ Porocarcinoma (nih.gov)].<ref name=pmid24403888>{{Cite journal  | last1 = Kurashige | first1 = Y. | last2 = Minemura | first2 = T. | last3 = Nagatani | first3 = T. | title = Eccrine porocarcinoma: clinical and pathological report of eight cases. | journal = Case Rep Dermatol | volume = 5 | issue = 3 | pages = 259-66 | month =  | year = 2013 | doi = 10.1159/000355606 | PMID = 24403888 }}</ref>
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884174/figure/F2/ Porocarcinoma (nih.gov)].<ref name=pmid24403888>{{Cite journal  | last1 = Kurashige | first1 = Y. | last2 = Minemura | first2 = T. | last3 = Nagatani | first3 = T. | title = Eccrine porocarcinoma: clinical and pathological report of eight cases. | journal = Case Rep Dermatol | volume = 5 | issue = 3 | pages = 259-66 | month =  | year = 2013 | doi = 10.1159/000355606 | PMID = 24403888 }}</ref>
==IHC==
Features:<ref>{{Cite journal  | last1 = Goto | first1 = K. | last2 = Takai | first2 = T. | last3 = Fukumoto | first3 = T. | last4 = Anan | first4 = T. | last5 = Kimura | first5 = T. | last6 = Ansai | first6 = S. | last7 = Oshitani | first7 = Y. | last8 = Murata | first8 = Y. | last9 = Sakuma | first9 = T. | title = CD117 (KIT) is a useful immunohistochemical marker for differentiating porocarcinoma from squamous cell carcinoma. | journal = J Cutan Pathol | volume = 43 | issue = 3 | pages = 219-26 | month = Mar | year = 2016 | doi = 10.1111/cup.12632 | PMID = 26449497 }}</ref>
*[[CD117]] +ve (~100% of porocarcinoma, ~20% of [[squamous carcinoma]]s focally).


==See also==
==See also==

Latest revision as of 19:24, 8 February 2019

Porocarcinoma
Diagnosis in short

Porocarcinoma. H&E stain.
LM DDx

basal cell carcinoma, squamous cell carcinoma, pyogenic granuloma, verruca vulgaris,

adenocarcinoma, malignant melanoma
IHC CD117 +ve
Site skin - typically head & neck

Prevalence very rare
Prognosis poor
Treatment surgical excision

Porocarcinoma is a rare malignant skin tumour that has an aggressive behaviour.[1]

It is also known as eccrine porocarcinoma (abbreviated EPC) and malignant eccrine poroma.[2]

General

  • Malignant counterpart of poroma.[3]
  • Very rare ~ most papers are case reports.[4]

Clinical features - based on meta-analysis of 453 cases:[1]

  • No predominance males versus females.
  • Aggressive behaviour >30% of cases have metastases at presentation - typically to lymph nodes.

Treatment:

  • Surgery,

Gross

  • Mass or nodule - typically head and neck (40% of cases) or lower extremity (34% of cases).[1]

Microscopic

Features:

  • Ductal/eccrine differentiation:[2]
    • Intracytoplasmic lumens.
    • Multicellular ducts with thin esoinophilic layer.
    • Lack granular cells and lack decapitated lumens - features of apocrine differentiation.
  • Features of malignancy:[2]
  • +/-Squamous differentiation.
  • +/-Basaloid differentiation.

DDx:[3]

Images

www

IHC

Features:[6]

See also

References

  1. 1.0 1.1 1.2 Salih, AM.; Kakamad, FH.; Baba, HO.; Salih, RQ.; Hawbash, MR.; Mohammed, SH.; Othman, S.; Saeed, YA. et al. (Aug 2017). "Porocarcinoma; presentation and management, a meta-analysis of 453 cases.". Ann Med Surg (Lond) 20: 74-79. doi:10.1016/j.amsu.2017.06.027. PMID 28721214.
  2. 2.0 2.1 2.2 Luz, Mde A.; Ogata, DC.; Montenegro, MF.; Biasi, LJ.; Ribeiro, LC. (Jul 2010). "Eccrine porocarcinoma (malignant eccrine poroma): a series of eight challenging cases.". Clinics (Sao Paulo) 65 (7): 739-42. doi:10.1590/S1807-59322010000700014. PMID 20668633.
  3. 3.0 3.1 3.2 Abarzúa, Á.; Álvarez-Véliz, S.; Moll-Manzur, C.. "Concomitant poroma and porocarcinoma.". An Bras Dermatol 92 (4): 550-552. doi:10.1590/abd1806-4841.20175719. PMID 28954110.
  4. Riera-Leal, L.; Guevara-Gutiérrez, E.; Barrientos-García, JG.; Madrigal-Kasem, R.; Briseño-Rodríguez, G.; Tlacuilo-Parra, A. (2015). "Eccrine porocarcinoma: epidemiologic and histopathologic characteristics.". Int J Dermatol 54 (5): 580-6. doi:10.1111/ijd.12714. PMID 25515648.
  5. Kurashige, Y.; Minemura, T.; Nagatani, T. (2013). "Eccrine porocarcinoma: clinical and pathological report of eight cases.". Case Rep Dermatol 5 (3): 259-66. doi:10.1159/000355606. PMID 24403888.
  6. Goto, K.; Takai, T.; Fukumoto, T.; Anan, T.; Kimura, T.; Ansai, S.; Oshitani, Y.; Murata, Y. et al. (Mar 2016). "CD117 (KIT) is a useful immunohistochemical marker for differentiating porocarcinoma from squamous cell carcinoma.". J Cutan Pathol 43 (3): 219-26. doi:10.1111/cup.12632. PMID 26449497.