Difference between revisions of "Reactive follicular hyperplasia"

Revision as of 15:17, 16 February 2021

Reactive follicular hyperplasia is a benign lymph node change.

Many causes - including: bacteria, viruses, chemicals, drugs, allergens.
- In only approximately 10% can definitive cause be identified.^[1]

Features:^[2]

DDx:

Screening panel:

Others:

↑ Ioachim, Harry L; Medeiros, L. Jeffrey (2008). Ioachim's Lymph Node Pathology (4th ed.). Lippincott Williams & Wilkins. pp. 174. ISBN 978-0781775960.
↑ Ioachim, Harry L; Medeiros, L. Jeffrey (2008). Ioachim's Lymph Node Pathology (4th ed.). Lippincott Williams & Wilkins. pp. 179. ISBN 978-0781775960.

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-#redirect [[Lymph_node_pathology#Reactive_follicular_hyperplasia]]
+'''Reactive follicular hyperplasia''' is a benign [[Lymph node pathology|lymph node change]].
+==General==
+*Many causes - including: bacteria, viruses, chemicals, drugs, allergens.
+**In only approximately 10% can definitive cause be identified.<ref name=Ref_ILNP174>{{Ref_ILNP|174}}</ref>
+==Microscopic==
+Features:<ref name=Ref_ILNP179>{{Ref_ILNP|179}}</ref>
+*Enlarged follicles, follicle size variation - '''key feature''' with:
+**Large germinal centers (pale on H&E).
+***Mitoses common.
+***Variable lymphocyte morphology.
+***Tingible-body macrophage (large, pale cells with junk in the cytoplasm).
+***Germinal centers (GCs) have a crisp/sharp edge.
+***Normal dark/light variation of GCs; superficial aspect light, deeper aspect darker.
+**Rim of small (inactive) lymphocytes.
+DDx:
+*[[Hodgkin lymphoma]] - with rare Reed-Sternberg cells.
+*Non-Hodgkin [[lymphoma]].
+**T-cell/histiocyte-rich large B cell lymphoma.
+Image: [http://pleiad.umdnj.edu/hemepath/normal_node/normal_node.html Normal lymph node (umdnj.edu)].
+==IHC==
+Screening panel:
+*[[CD3]].
+*[[CD5]].
+*CD10.
+*[[CD20]].
+*CD30.
+*CD15.
+Others:
+*BCL2 -ve.
+==See also==
+*[[Lymph node pathology]].
+==References==
+{{Reflist|1}}
 [[Category:Diagnosis]]