Difference between revisions of "Classification of urothelial carcinoma by immunohistochemistry"
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A '''classification of [[urothelial carcinoma]] by immunohistochemistry''' can be done with three [[immunostains]].<ref name=pmid34103388 >{{cite journal |vauthors=Olkhov-Mitsel E, Hodgson A, Liu SK, Vesprini D, Xu B, Downes MR |title=Three-antibody classifier for muscle invasive urothelial carcinoma and its correlation with p53 expression |journal=J Clin Pathol |volume= |issue= |pages= |date=June 2021 |pmid=34103388 |doi=10.1136/jclinpath-2021-207573 |url=}}</ref> | A '''classification of [[urothelial carcinoma]] by immunohistochemistry''' can be done with three [[immunostains]].<ref name=pmid34103388 >{{cite journal |vauthors=Olkhov-Mitsel E, Hodgson A, Liu SK, Vesprini D, Xu B, Downes MR |title=Three-antibody classifier for muscle invasive urothelial carcinoma and its correlation with p53 expression |journal=J Clin Pathol |volume= |issue= |pages= |date=June 2021 |pmid=34103388 |doi=10.1136/jclinpath-2021-207573 |url=}}</ref> | ||
==General== | |||
===A simple classification of urothelial carcinoma=== | |||
{{familytree/start}} | |||
{{familytree | | | | | | | | | A01 | | | | |A01=[[Urothelial carcinoma]]}} | |||
{{familytree | | | | |,|-|-|-|-|^|-|-|-|-|.|}} | |||
{{familytree | | | | B01 | | | | | | | | B02|B01=Luminal type<br>GATA3 +ve, CK5/6 -ve|B02=Basal type<br>CK5/6 +ve, GATA3 -ve }} | |||
{{familytree | |,|-|-|^|-|-|.| | | | | | | | | | | | |}} | |||
{{familytree | C01 | | | | C02 | | | | | | | | | | | |C01=Genomically unstable<br>p16 +ve|C02=Urothelial-like<br>p16 -ve}} | |||
{{familytree/end}} | |||
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Revision as of 18:29, 15 October 2021
A classification of urothelial carcinoma by immunohistochemistry can be done with three immunostains.[1]
General
A simple classification of urothelial carcinoma
| Urothelial carcinoma | |||||||||||||||||||||||||||||||||||||||||
| Luminal type GATA3 +ve, CK5/6 -ve | Basal type CK5/6 +ve, GATA3 -ve | ||||||||||||||||||||||||||||||||||||||||
| Genomically unstable p16 +ve | Urothelial-like p16 -ve | ||||||||||||||||||||||||||||||||||||||||
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The immunoprofile (GATA3 POSITIVE, p16 POSITIVE, CK5/6 negative,) is in keeping with UROTHELIAL CARCINOMA, LUMINAL TYPE, GENOMICALLY UNSTABLE.
The immunoprofile (GATA3 POSITIVE, p16 negative, CK5/6 negative) is in keeping with UROTHELIAL CARCINOMA, LUMINAL TYPE, UROTHELIAL-LIKE.
The immunoprofile (CK5/6 POSITIVE, GATA3 negative) is in keeping with UROTHELIAL CARCINOMA, BASAL TYPE.
See also
References
- ↑ "Three-antibody classifier for muscle invasive urothelial carcinoma and its correlation with p53 expression". J Clin Pathol. June 2021. doi:10.1136/jclinpath-2021-207573. PMID 34103388.