Difference between revisions of "Invasive lobular carcinoma"
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| LMDDx = [[invasive ductal carcinoma of the breast]] with lobular features, poorly differentiated carcinoma, [[LCIS]] | | LMDDx = [[invasive ductal carcinoma of the breast]] with lobular features, poorly differentiated carcinoma, [[LCIS]] | ||
| Stains = | | Stains = | ||
| IHC = E-cadherin -ve, usu. ER and PR +ve, HER2 -ve, CK7 +ve | | IHC = [[E-cadherin]] -ve, usu. ER and PR +ve, HER2 -ve, [[CK7]] +ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
| IF = | | IF = | ||
| Gross = | | Gross = | ||
| Grossing = | | Grossing = [[breast grossing]] | ||
| Staging = [[breast cancer staging]] | |||
| Site = [[breast]] - see ''[[invasive breast cancer]]'' | | Site = [[breast]] - see ''[[invasive breast cancer]]'' | ||
| Assdx = | | Assdx = | ||
| Line 54: | Line 55: | ||
*Poorly differentiated carcinoma. | *Poorly differentiated carcinoma. | ||
*[[LCIS]]. | *[[LCIS]]. | ||
*[[Malignant melanoma]]. | |||
===Subclassification=== | ===Subclassification=== | ||
| Line 74: | Line 65: | ||
Note: | Note: | ||
*Some pathologist grade lobular carcinoma like other types and avoid the term "pleomorphic lobular carcinoma."<ref>MUA. Jan 22, 2009.</ref> | *Some pathologist grade lobular carcinoma like other types and avoid the term "pleomorphic lobular carcinoma."<ref>MUA. Jan 22, 2009.</ref> | ||
Other variants: | |||
*Histiocytoid.<ref name=pmid21398688>{{Cite journal | last1 = Tan | first1 = PH. | last2 = Harada | first2 = O. | last3 = Thike | first3 = AA. | last4 = Tse | first4 = GM. | title = Histiocytoid breast carcinoma: an enigmatic lobular entity. | journal = J Clin Pathol | volume = 64 | issue = 8 | pages = 654-9 | month = Aug | year = 2011 | doi = 10.1136/jcp.2011.088930 | PMID = 21398688 }}</ref> | |||
===Images=== | |||
<gallery> | |||
Image:Lobular_carcinoma_-_low_mag.jpg | Lobular carcinoma - low mag. (WC/Nephron) | |||
Image:Lobular_carcinoma_-_high_mag.jpg | Lobular carcinoma - high mag. (WC/Nephron) | |||
Image:Lobular_carcinoma_-_high_mag.jpg | Lobular carcinoma - very high mag. (WC/Nephron) | |||
</gallery> | |||
<gallery> | |||
Image:Breast_invasive_lobular_carcinoma_%281%29.jpg | Lobular carcinoma - 1 (WC) | |||
Image:Breast_invasive_lobular_carcinoma_%282%29.jpg | Lobular carcinoma - 2 (WC) | |||
</gallery> | |||
==IHC== | ==IHC== | ||
Features: | Features: | ||
*E-cadherin -ve. | *[[E-cadherin]] -ve. | ||
*ER and PR +ve. | *ER and PR +ve. | ||
*HER2 -ve. | *HER2 -ve. | ||
| Line 84: | Line 89: | ||
Others: | Others: | ||
*CK20 -ve. | *CK20 -ve. | ||
*Beta-catenin -ve/+ve (~46% completely negative<ref name=pmid11237489>{{cite journal |authors=Karayiannakis AJ, Nakopoulou L, Gakiopoulou H, Keramopoulos A, Davaris PS, Pignatelli M |title=Expression patterns of beta-catenin in in situ and invasive breast cancer |journal=Eur J Surg Oncol |volume=27 |issue=1 |pages=31–6 |date=February 2001 |pmid=11237489 |doi=10.1053/ejso.1999.1017 |url=}}</ref>). | |||
==See also== | ==See also== | ||
Latest revision as of 19:26, 20 December 2021
| Invasive lobular carcinoma | |
|---|---|
| Diagnosis in short | |
 Lobular carcinoma. H&E stain. | |
| LM DDx | invasive ductal carcinoma of the breast with lobular features, poorly differentiated carcinoma, LCIS |
| IHC | E-cadherin -ve, usu. ER and PR +ve, HER2 -ve, CK7 +ve |
| Grossing notes | breast grossing |
| Staging | breast cancer staging |
| Site | breast - see invasive breast cancer |
|
| |
| Syndromes | hereditary diffuse gastric cancer |
|
| |
| Prevalence | relatively common |
| Clin. DDx | other breast tumours |
Invasive lobular carcinoma, abbreviated ILC, is the second most common form of Invasive breast cancer.
It may be referred to as lobular carcinoma; however, this may lead to confusion with lobular carcinoma in situ.
General
Microscopic
Features:
- "Single file" - cell line-up in a row.
- Cell should not be cohesive -- lymphoma should briefly come to mind.
- primary lymphoma of the breast exists... but it is extremely rare.
- Cell should not be cohesive -- lymphoma should briefly come to mind.
- NO gland formation.
- If it forms glands... it is more likely NST.
- May have signet ring morphology.
- NO desmoplastic reaction, i.e. the stroma surrounding the tumour cells should look benign and undisturbed.
Note:
- Commonly have low grade nuclear features.
DDx:
- Invasive ductal carcinoma of the breast with lobular features.
- Poorly differentiated carcinoma.
- LCIS.
- Malignant melanoma.
Subclassification
- Classic lobular carcinoma.
- Low nuclear grade - NO significant variation of nucleus size.
- Pleomorphic lobular carcinoma.
- Significant nuclear atypia.
Note:
- Some pathologist grade lobular carcinoma like other types and avoid the term "pleomorphic lobular carcinoma."[3]
Other variants:
- Histiocytoid.[4]
Images
Lobular carcinoma - low mag. (WC/Nephron)
Lobular carcinoma - high mag. (WC/Nephron)
Lobular carcinoma - very high mag. (WC/Nephron)
Lobular carcinoma - 1 (WC)
Lobular carcinoma - 2 (WC)
.jpg)
.jpg)
IHC
Features:
- E-cadherin -ve.
- ER and PR +ve.
- HER2 -ve.
- CK7 +ve.
Others:
- CK20 -ve.
- Beta-catenin -ve/+ve (~46% completely negative[5]).
See also
References
- ↑ URL: http://www.asco.org/ascov2/Meetings/Abstracts?&vmview=abst_detail_view&confID=65&abstractID=33006. Accessed on: 19 April 2011.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 192090
- ↑ MUA. Jan 22, 2009.
- ↑ Tan, PH.; Harada, O.; Thike, AA.; Tse, GM. (Aug 2011). "Histiocytoid breast carcinoma: an enigmatic lobular entity.". J Clin Pathol 64 (8): 654-9. doi:10.1136/jcp.2011.088930. PMID 21398688.
- ↑ Karayiannakis AJ, Nakopoulou L, Gakiopoulou H, Keramopoulos A, Davaris PS, Pignatelli M (February 2001). "Expression patterns of beta-catenin in in situ and invasive breast cancer". Eur J Surg Oncol 27 (1): 31–6. doi:10.1053/ejso.1999.1017. PMID 11237489.