Difference between revisions of "Lymphoepithelioma-like carcinoma of the urinary bladder"

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'''Lymphoepithelioma-like carcinoma of the urinary bladder''', also '''urinary bladder lymphoepithelioma-like carcinoma''' ('''urinary bladder LELC'''), is a rare variant of [[urothelial carcinoma]].<ref name=pmid19494856>{{Cite journal  | last1 = Amin | first1 = MB. | title = Histological variants of urothelial carcinoma: diagnostic, therapeutic and prognostic implications. | journal = Mod Pathol | volume = 22 Suppl 2 | issue =  | pages = S96-S118 | month = Jun | year = 2009 | doi = 10.1038/modpathol.2009.26 | PMID = 19494856 }}</ref>
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Urinary bladder LELC -- very high mag.jpg
| Width      =
| Caption    = Urinary bladder lymphoepithelioma-like carcinoma. [[H&E stain]].
| Synonyms  =
| Micro      = squamoid cells with abundant dense cytoplasm central nuclei +/- small/indistinct nucleoli, prominent lymphoid infiltrate
| Subtypes  = (subtype of [[urothelial carcinoma]])
| LMDDx      = [[lymphoma]], [[urothelial carcinoma]] and inflammation, metastatic [[lymphoepithelioma-like carcinoma]]
| Stains    =
| IHC        = [[CK34betaE12]] +ve, p63 +ve/-ve, [[CK7]] +ve/-ve, [[CK20]] -ve, CD30 -ve
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[urinary bladder]] - see ''[[urothelium]]''
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = rare
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = favourable on limited data
| Other      = not associated with [[EBV]]
| ClinDDx    =
| Tx        =
}}
'''Lymphoepithelioma-like carcinoma of the urinary bladder''', also '''urinary bladder lymphoepithelioma-like carcinoma''' (abbreviated '''UBLELC'''), is a rare variant of [[urothelial carcinoma]].<ref name=pmid19494856>{{Cite journal  | last1 = Amin | first1 = MB. | title = Histological variants of urothelial carcinoma: diagnostic, therapeutic and prognostic implications. | journal = Mod Pathol | volume = 22 Suppl 2 | issue =  | pages = S96-S118 | month = Jun | year = 2009 | doi = 10.1038/modpathol.2009.26 | PMID = 19494856 }}</ref>


==General==
==General==
*Rare.
*Not associated with [[EBV]].<ref name=pmid21383609>{{Cite journal  | last1 = Williamson | first1 = SR. | last2 = Zhang | first2 = S. | last3 = Lopez-Beltran | first3 = A. | last4 = Shah | first4 = RB. | last5 = Montironi | first5 = R. | last6 = Tan | first6 = PH. | last7 = Wang | first7 = M. | last8 = Baldridge | first8 = LA. | last9 = MacLennan | first9 = GT. | title = Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features. | journal = Am J Surg Pathol | volume = 35 | issue = 4 | pages = 474-83 | month = Apr | year = 2011 | doi = 10.1097/PAS.0b013e31820f709e | PMID = 21383609 }}</ref>
*Not associated with [[EBV]].<ref name=pmid21383609>{{Cite journal  | last1 = Williamson | first1 = SR. | last2 = Zhang | first2 = S. | last3 = Lopez-Beltran | first3 = A. | last4 = Shah | first4 = RB. | last5 = Montironi | first5 = R. | last6 = Tan | first6 = PH. | last7 = Wang | first7 = M. | last8 = Baldridge | first8 = LA. | last9 = MacLennan | first9 = GT. | title = Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features. | journal = Am J Surg Pathol | volume = 35 | issue = 4 | pages = 474-83 | month = Apr | year = 2011 | doi = 10.1097/PAS.0b013e31820f709e | PMID = 21383609 }}</ref>
*Good prognosis on scant data<ref>{{Cite journal  | last1 = Fujino | first1 = T. | last2 = Kubota | first2 = M. | last3 = Nishiyama | first3 = R. | last4 = Kanno | first4 = T. | last5 = Okada | first5 = T. | last6 = Higashi | first6 = Y. | last7 = Yamada | first7 = H. | last8 = Okamoto | first8 = E. | title = [A case of lymphoepithelioma-like carcinoma of the bladder]. | journal = Hinyokika Kiyo | volume = 60 | issue = 10 | pages = 507-11 | month = Oct | year = 2014 | doi =  | PMID = 25391783 }}</ref> - possibly poor if metastatic.


==Microscopic==
==Microscopic==
:See ''[[lymphoepithelioma-like carcinoma]]''.
Features:
*Clusters of (cohesive) squamoid cells with:
**Abundant dense cytoplasm.
**Central nuclei +/- small/indistinct nucleoli.
*Prominent lymphoid infiltrate - '''key feature'''.
*+/-[[Urothelial carcinoma in situ]].
 
Note:
*Peritumoural lymphoid aggregates are typical.<ref name=pmid19847088>{{Cite journal  | last1 = Singh | first1 = NG. | last2 = Mannan | first2 = AA. | last3 = Rifaat | first3 = AA. | last4 = Kahvic | first4 = M. | title = Lymphoepithelioma-like carcinoma of the urinary bladder: report of a rare case. | journal = Ann Saudi Med | volume = 29 | issue = 6 | pages = 478-81 | month =  | year =  | doi = 10.4103/0256-4947.57173 | PMID = 19847088 }}</ref>
 
DDx:
*[[Lymphoma]].
*[[Urothelial carcinoma]] and inflammation.
*Metastatic [[lymphoepithelioma-like carcinoma]].


===Images===
===Images===
<gallery>
Image: Urinary bladder LELC -- low mag.jpg | UBLELC - low mag. (WC)
Image: Urinary bladder LELC -- intermed mag.jpg | UBLELC - intermed. mag. (WC)
Image: Urinary bladder LELC - a1t 2 -- intermed mag.jpg | UBLELC - intermed. mag. (WC)
Image: Urinary bladder LELC -- high mag.jpg | UBLELC - high mag. (WC)
Image: Urinary bladder LELC -- very high mag.jpg | UBLELC - very high mag. (WC)
</gallery>
www:
www:
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881438/figure/F0002/ LELC of the urinary bladder - low mag. (nih.gov)].<ref name=pmid19847088>{{Cite journal  | last1 = Singh | first1 = NG. | last2 = Mannan | first2 = AA. | last3 = Rifaat | first3 = AA. | last4 = Kahvic | first4 = M. | title = Lymphoepithelioma-like carcinoma of the urinary bladder: report of a rare case. | journal = Ann Saudi Med | volume = 29 | issue = 6 | pages = 478-81 | month =  | year =  | doi = 10.4103/0256-4947.57173 | PMID = 19847088 }}
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881438/figure/F0002/ LELC of the urinary bladder - low mag. (nih.gov)].<ref name=pmid19847088>{{Cite journal  | last1 = Singh | first1 = NG. | last2 = Mannan | first2 = AA. | last3 = Rifaat | first3 = AA. | last4 = Kahvic | first4 = M. | title = Lymphoepithelioma-like carcinoma of the urinary bladder: report of a rare case. | journal = Ann Saudi Med | volume = 29 | issue = 6 | pages = 478-81 | month =  | year =  | doi = 10.4103/0256-4947.57173 | PMID = 19847088 }}</ref>
</ref>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881438/figure/F0003/ LELC of the urinary bladder - high mag. (nih.gov)].<ref name=pmid19847088/>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881438/figure/F0003/ LELC of the urinary bladder - high mag. (nih.gov)].<ref name=pmid19847088/>
==IHC==
Features:<ref name=pmid21383609/>
*p53 +ve/-ve. (+ve in ~60% of cases).
*CK34betaE12 +ve (+ve in ~75% of cases).
*CK7 +ve/-ve (+ve in ~60% of cases).
*p63 +ve/-ve (+ve in ~50% of cases).
Others:<ref name=pmid21383609/>
*CK20 -ve.
*TTF-1 -ve.
*CD30 -ve.


==See also==
==See also==
*[[Urothelial carcinoma]].
*[[Urothelial carcinoma]].
*[[Urinary bladder]].
*[[Urinary bladder]].
*[[Lymphoepithelioma-like carcinoma]].
*[[Nasopharyngeal carcinoma]].


==References==
==References==

Latest revision as of 14:50, 4 August 2022

Lymphoepithelioma-like carcinoma of the urinary bladder
Diagnosis in short

Urinary bladder lymphoepithelioma-like carcinoma. H&E stain.
LM squamoid cells with abundant dense cytoplasm central nuclei +/- small/indistinct nucleoli, prominent lymphoid infiltrate
Subtypes (subtype of urothelial carcinoma)
LM DDx lymphoma, urothelial carcinoma and inflammation, metastatic lymphoepithelioma-like carcinoma
IHC CK34betaE12 +ve, p63 +ve/-ve, CK7 +ve/-ve, CK20 -ve, CD30 -ve
Site urinary bladder - see urothelium
Prevalence rare
Prognosis favourable on limited data
Other not associated with EBV

Lymphoepithelioma-like carcinoma of the urinary bladder, also urinary bladder lymphoepithelioma-like carcinoma (abbreviated UBLELC), is a rare variant of urothelial carcinoma.[1]

General

  • Rare.
  • Not associated with EBV.[2]
  • Good prognosis on scant data[3] - possibly poor if metastatic.

Microscopic

Features:

  • Clusters of (cohesive) squamoid cells with:
    • Abundant dense cytoplasm.
    • Central nuclei +/- small/indistinct nucleoli.
  • Prominent lymphoid infiltrate - key feature.
  • +/-Urothelial carcinoma in situ.

Note:

  • Peritumoural lymphoid aggregates are typical.[4]

DDx:

Images

  • UBLELC - low mag. (WC)

  • UBLELC - intermed. mag. (WC)

  • UBLELC - intermed. mag. (WC)

  • UBLELC - high mag. (WC)

  • UBLELC - very high mag. (WC)

www:

IHC

Features:[2]

  • p53 +ve/-ve. (+ve in ~60% of cases).
  • CK34betaE12 +ve (+ve in ~75% of cases).
  • CK7 +ve/-ve (+ve in ~60% of cases).
  • p63 +ve/-ve (+ve in ~50% of cases).

Others:[2]

  • CK20 -ve.
  • TTF-1 -ve.
  • CD30 -ve.

See also

References

  1. ↑ Amin, MB. (Jun 2009). "Histological variants of urothelial carcinoma: diagnostic, therapeutic and prognostic implications.". Mod Pathol 22 Suppl 2: S96-S118. doi:10.1038/modpathol.2009.26. PMID 19494856.
  2. ↑ 2.0 2.1 2.2 Williamson, SR.; Zhang, S.; Lopez-Beltran, A.; Shah, RB.; Montironi, R.; Tan, PH.; Wang, M.; Baldridge, LA. et al. (Apr 2011). "Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features.". Am J Surg Pathol 35 (4): 474-83. doi:10.1097/PAS.0b013e31820f709e. PMID 21383609.
  3. ↑ Fujino, T.; Kubota, M.; Nishiyama, R.; Kanno, T.; Okada, T.; Higashi, Y.; Yamada, H.; Okamoto, E. (Oct 2014). "[A case of lymphoepithelioma-like carcinoma of the bladder].". Hinyokika Kiyo 60 (10): 507-11. PMID 25391783.
  4. ↑ 4.0 4.1 4.2 Singh, NG.; Mannan, AA.; Rifaat, AA.; Kahvic, M.. "Lymphoepithelioma-like carcinoma of the urinary bladder: report of a rare case.". Ann Saudi Med 29 (6): 478-81. doi:10.4103/0256-4947.57173. PMID 19847088.
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