Difference between revisions of "Lymphoepithelioma-like carcinoma of the urinary bladder"
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| Caption = Urinary bladder lymphoepithelioma-like carcinoma. [[H&E stain]]. | | Caption = Urinary bladder lymphoepithelioma-like carcinoma. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = | ||
| Micro = | | Micro = squamoid cells with abundant dense cytoplasm central nuclei +/- small/indistinct nucleoli, prominent lymphoid infiltrate | ||
| Subtypes = subtype of [[urothelial carcinoma]] | | Subtypes = (subtype of [[urothelial carcinoma]]) | ||
| LMDDx = | | LMDDx = [[lymphoma]], [[urothelial carcinoma]] and inflammation, metastatic [[lymphoepithelioma-like carcinoma]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = [[CK34betaE12]] +ve, p63 +ve/-ve, [[CK7]] +ve/-ve, [[CK20]] -ve, CD30 -ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
| Line 25: | Line 25: | ||
| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = | | Prognosis = favourable on limited data | ||
| Other = not associated with [[EBV]] | | Other = not associated with [[EBV]] | ||
| ClinDDx = | | ClinDDx = | ||
| Line 35: | Line 35: | ||
*Rare. | *Rare. | ||
*Not associated with [[EBV]].<ref name=pmid21383609>{{Cite journal | last1 = Williamson | first1 = SR. | last2 = Zhang | first2 = S. | last3 = Lopez-Beltran | first3 = A. | last4 = Shah | first4 = RB. | last5 = Montironi | first5 = R. | last6 = Tan | first6 = PH. | last7 = Wang | first7 = M. | last8 = Baldridge | first8 = LA. | last9 = MacLennan | first9 = GT. | title = Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features. | journal = Am J Surg Pathol | volume = 35 | issue = 4 | pages = 474-83 | month = Apr | year = 2011 | doi = 10.1097/PAS.0b013e31820f709e | PMID = 21383609 }}</ref> | *Not associated with [[EBV]].<ref name=pmid21383609>{{Cite journal | last1 = Williamson | first1 = SR. | last2 = Zhang | first2 = S. | last3 = Lopez-Beltran | first3 = A. | last4 = Shah | first4 = RB. | last5 = Montironi | first5 = R. | last6 = Tan | first6 = PH. | last7 = Wang | first7 = M. | last8 = Baldridge | first8 = LA. | last9 = MacLennan | first9 = GT. | title = Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features. | journal = Am J Surg Pathol | volume = 35 | issue = 4 | pages = 474-83 | month = Apr | year = 2011 | doi = 10.1097/PAS.0b013e31820f709e | PMID = 21383609 }}</ref> | ||
*Good prognosis on scant data<ref>{{Cite journal | last1 = Fujino | first1 = T. | last2 = Kubota | first2 = M. | last3 = Nishiyama | first3 = R. | last4 = Kanno | first4 = T. | last5 = Okada | first5 = T. | last6 = Higashi | first6 = Y. | last7 = Yamada | first7 = H. | last8 = Okamoto | first8 = E. | title = [A case of lymphoepithelioma-like carcinoma of the bladder]. | journal = Hinyokika Kiyo | volume = 60 | issue = 10 | pages = 507-11 | month = Oct | year = 2014 | doi = | PMID = 25391783 }}</ref> - possibly poor if metastatic. | |||
==Microscopic== | ==Microscopic== | ||
: | Features: | ||
*Clusters of (cohesive) squamoid cells with: | |||
**Abundant dense cytoplasm. | |||
**Central nuclei +/- small/indistinct nucleoli. | |||
*Prominent lymphoid infiltrate - '''key feature'''. | |||
*+/-[[Urothelial carcinoma in situ]]. | |||
Note: | |||
*Peritumoural lymphoid aggregates are typical.<ref name=pmid19847088>{{Cite journal | last1 = Singh | first1 = NG. | last2 = Mannan | first2 = AA. | last3 = Rifaat | first3 = AA. | last4 = Kahvic | first4 = M. | title = Lymphoepithelioma-like carcinoma of the urinary bladder: report of a rare case. | journal = Ann Saudi Med | volume = 29 | issue = 6 | pages = 478-81 | month = | year = | doi = 10.4103/0256-4947.57173 | PMID = 19847088 }}</ref> | |||
DDx: | DDx: | ||
* | *[[Lymphoma]]. | ||
*[[Urothelial carcinoma]] and inflammation. | |||
*Metastatic [[lymphoepithelioma-like carcinoma]]. | *Metastatic [[lymphoepithelioma-like carcinoma]]. | ||
| Line 52: | Line 62: | ||
</gallery> | </gallery> | ||
www: | www: | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881438/figure/F0002/ LELC of the urinary bladder - low mag. (nih.gov)].<ref name=pmid19847088>{{Cite journal | last1 = Singh | first1 = NG. | last2 = Mannan | first2 = AA. | last3 = Rifaat | first3 = AA. | last4 = Kahvic | first4 = M. | title = Lymphoepithelioma-like carcinoma of the urinary bladder: report of a rare case. | journal = Ann Saudi Med | volume = 29 | issue = 6 | pages = 478-81 | month = | year = | doi = 10.4103/0256-4947.57173 | PMID = 19847088 }} | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881438/figure/F0002/ LELC of the urinary bladder - low mag. (nih.gov)].<ref name=pmid19847088>{{Cite journal | last1 = Singh | first1 = NG. | last2 = Mannan | first2 = AA. | last3 = Rifaat | first3 = AA. | last4 = Kahvic | first4 = M. | title = Lymphoepithelioma-like carcinoma of the urinary bladder: report of a rare case. | journal = Ann Saudi Med | volume = 29 | issue = 6 | pages = 478-81 | month = | year = | doi = 10.4103/0256-4947.57173 | PMID = 19847088 }}</ref> | ||
</ref> | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881438/figure/F0003/ LELC of the urinary bladder - high mag. (nih.gov)].<ref name=pmid19847088/> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881438/figure/F0003/ LELC of the urinary bladder - high mag. (nih.gov)].<ref name=pmid19847088/> | ||
==IHC== | |||
Features:<ref name=pmid21383609/> | |||
*p53 +ve/-ve. (+ve in ~60% of cases). | |||
*CK34betaE12 +ve (+ve in ~75% of cases). | |||
*CK7 +ve/-ve (+ve in ~60% of cases). | |||
*p63 +ve/-ve (+ve in ~50% of cases). | |||
Others:<ref name=pmid21383609/> | |||
*CK20 -ve. | |||
*TTF-1 -ve. | |||
*CD30 -ve. | |||
==See also== | ==See also== | ||
*[[Urothelial carcinoma]]. | *[[Urothelial carcinoma]]. | ||
*[[Urinary bladder]]. | *[[Urinary bladder]]. | ||
*[[Lymphoepithelioma-like carcinoma]]. | |||
*[[Nasopharyngeal carcinoma]]. | |||
==References== | ==References== | ||
Latest revision as of 14:50, 4 August 2022
| Lymphoepithelioma-like carcinoma of the urinary bladder | |
|---|---|
| Diagnosis in short | |
 Urinary bladder lymphoepithelioma-like carcinoma. H&E stain. | |
|
| |
| LM | squamoid cells with abundant dense cytoplasm central nuclei +/- small/indistinct nucleoli, prominent lymphoid infiltrate |
| Subtypes | (subtype of urothelial carcinoma) |
| LM DDx | lymphoma, urothelial carcinoma and inflammation, metastatic lymphoepithelioma-like carcinoma |
| IHC | CK34betaE12 +ve, p63 +ve/-ve, CK7 +ve/-ve, CK20 -ve, CD30 -ve |
| Site | urinary bladder - see urothelium |
|
| |
| Prevalence | rare |
| Prognosis | favourable on limited data |
| Other | not associated with EBV |
Lymphoepithelioma-like carcinoma of the urinary bladder, also urinary bladder lymphoepithelioma-like carcinoma (abbreviated UBLELC), is a rare variant of urothelial carcinoma.[1]
General
Microscopic
Features:
- Clusters of (cohesive) squamoid cells with:
- Abundant dense cytoplasm.
- Central nuclei +/- small/indistinct nucleoli.
- Prominent lymphoid infiltrate - key feature.
- +/-Urothelial carcinoma in situ.
Note:
- Peritumoural lymphoid aggregates are typical.[4]
DDx:
- Lymphoma.
- Urothelial carcinoma and inflammation.
- Metastatic lymphoepithelioma-like carcinoma.
Images
UBLELC - low mag. (WC)
UBLELC - intermed. mag. (WC)
UBLELC - intermed. mag. (WC)
UBLELC - high mag. (WC)
UBLELC - very high mag. (WC)
www:
- LELC of the urinary bladder - low mag. (nih.gov).[4]
- LELC of the urinary bladder - high mag. (nih.gov).[4]
IHC
Features:[2]
- p53 +ve/-ve. (+ve in ~60% of cases).
- CK34betaE12 +ve (+ve in ~75% of cases).
- CK7 +ve/-ve (+ve in ~60% of cases).
- p63 +ve/-ve (+ve in ~50% of cases).
Others:[2]
- CK20 -ve.
- TTF-1 -ve.
- CD30 -ve.
See also
References
- ↑ Amin, MB. (Jun 2009). "Histological variants of urothelial carcinoma: diagnostic, therapeutic and prognostic implications.". Mod Pathol 22 Suppl 2: S96-S118. doi:10.1038/modpathol.2009.26. PMID 19494856.
- ↑ 2.0 2.1 2.2 Williamson, SR.; Zhang, S.; Lopez-Beltran, A.; Shah, RB.; Montironi, R.; Tan, PH.; Wang, M.; Baldridge, LA. et al. (Apr 2011). "Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features.". Am J Surg Pathol 35 (4): 474-83. doi:10.1097/PAS.0b013e31820f709e. PMID 21383609.
- ↑ Fujino, T.; Kubota, M.; Nishiyama, R.; Kanno, T.; Okada, T.; Higashi, Y.; Yamada, H.; Okamoto, E. (Oct 2014). "[A case of lymphoepithelioma-like carcinoma of the bladder].". Hinyokika Kiyo 60 (10): 507-11. PMID 25391783.
- ↑ 4.0 4.1 4.2 Singh, NG.; Mannan, AA.; Rifaat, AA.; Kahvic, M.. "Lymphoepithelioma-like carcinoma of the urinary bladder: report of a rare case.". Ann Saudi Med 29 (6): 478-81. doi:10.4103/0256-4947.57173. PMID 19847088.