Difference between revisions of "Mesonephric remnant of the prostate gland"

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'''Mesonephric remnant hyperplasia of the prostate gland''', also '''mesonephric remnant''', is rare benign finding in the [[prostate gland]] that can be confused with [[malignancy]].
'''Mesonephric remnant of the prostate gland''', also '''mesonephric remnant''', is rare benign finding in the [[prostate gland]] that can be confused with [[prostate carcinoma]].
 
This article also deals with '''mesonephric remnant hyperplasia'''.


==General==
==General==
*Very rare.<ref name=pmid21606823>{{Cite journal  | last1 = Chen | first1 = YB. | last2 = Fine | first2 = SW. | last3 = Epstein | first3 = JI. | title = Mesonephric remnant hyperplasia involving prostate and periprostatic tissue: findings at radical prostatectomy. | journal = Am J Surg Pathol | volume = 35 | issue = 7 | pages = 1054-61 | month = Jul | year = 2011 | doi = 10.1097/PAS.0b013e318218df97 | PMID = 21606823 }}</ref>
*Very rare<ref name=pmid21606823>{{Cite journal  | last1 = Chen | first1 = YB. | last2 = Fine | first2 = SW. | last3 = Epstein | first3 = JI. | title = Mesonephric remnant hyperplasia involving prostate and periprostatic tissue: findings at radical prostatectomy. | journal = Am J Surg Pathol | volume = 35 | issue = 7 | pages = 1054-61 | month = Jul | year = 2011 | doi = 10.1097/PAS.0b013e318218df97 | PMID = 21606823 }}</ref> ~ 0.6% incidence in a series of almost 700 [[TURP]] specimens.<ref name=pmid12861057>{{Cite journal  | last1 = Bostwick | first1 = DG. | last2 = Qian | first2 = J. | last3 = Ma | first3 = J. | last4 = Muir | first4 = TE. | title = Mesonephric remnants of the prostate: incidence and histologic spectrum. | journal = Mod Pathol | volume = 16 | issue = 7 | pages = 630-5 | month = Jul | year = 2003 | doi = 10.1097/01.MP.0000074733.10777.78 | PMID = 12861057 }}</ref>
*Can mimic prostate carcinoma.
*Can mimic prostate carcinoma.<ref name=pmid19917478>{{Cite journal  | last1 = Yacoub | first1 = M. | last2 = Milin | first2 = S. | last3 = Irani | first3 = J. | last4 = Fromont | first4 = G. | title = Mesonephric remnant hyperplasia: an unusual benign mimicker of prostate cancer. | journal = Ann Diagn Pathol | volume = 13 | issue = 6 | pages = 402-4 | month = Dec | year = 2009 | doi = 10.1016/j.anndiagpath.2009.03.008 | PMID = 19917478 }}</ref>


==Microscopic==
==Microscopic==
Features:<ref name=pmid21606823/>
Features:<ref name=pmid21606823/>
*Small glands with small bland appearing cuboidal cells in a lobular arrangement.
*Small glands in a lobular arrangement composed of cuboidal cells with:
**Scant-to-moderate cytoplasm.<ref name=pmid12861057/>
**Small/indistinct nucleoli.
 
Note:
*May look like Gleason pattern 3 adenocarcinoma.


DDx:<ref name=pmid21606823/>
DDx:<ref name=pmid21606823/>
*[[Sclerosing adenosis]] of the prostate gland.
*[[Sclerosing adenosis]] of the prostate gland.
*[[Prostate carcinoma]] - esp. Gleason pattern 5.
*[[Prostate carcinoma]] - esp. Gleason pattern 5.
===Images===
www:
*[http://www.nature.com/modpathol/journal/v16/n7/fig_tab/3880816f1.html#figure-title Mesonephric remnants (nature.com)].<ref name=pmid12861057/>


==IHC==
==IHC==
Features:<ref name=pmid21606823/>
Features:<ref name=pmid21606823/>
*PAX8 +ve.
*[[PAX8]] +ve.
*PSA -ve (all).
*[[PSA]] -ve (all).
*CK34betaE12 +ve/-ve (diffuse +ve in 4/7 cases)
*[[PSAP]] -ve.<ref name=pmid12861057/>
*p63 -ve.
*[[CK34betaE12]] +ve/-ve (diffuse +ve in 4/7 cases)
*AMACR +ve (focal).
*[[p63]] -ve.
*[[AMACR]] +ve (focal).


==See also==
==See also==
*[[Prostate gland]].
*[[Prostate gland]].
*[[Prostate cancer]].
*[[Prostate cancer]].
*[[Nephrogenic adenoma]].


==References==
==References==
{{Reflist|1}}
{{Reflist|2}}


[[Category:Prostate gland]]
[[Category:Prostate gland]]
[[Category:Diagnosis]]
[[Category:Diagnosis]]

Latest revision as of 14:52, 4 August 2022

Mesonephric remnant of the prostate gland, also mesonephric remnant, is rare benign finding in the prostate gland that can be confused with prostate carcinoma.

This article also deals with mesonephric remnant hyperplasia.

General

  • Very rare[1] ~ 0.6% incidence in a series of almost 700 TURP specimens.[2]
  • Can mimic prostate carcinoma.[3]

Microscopic

Features:[1]

  • Small glands in a lobular arrangement composed of cuboidal cells with:
    • Scant-to-moderate cytoplasm.[2]
    • Small/indistinct nucleoli.

Note:

  • May look like Gleason pattern 3 adenocarcinoma.

DDx:[1]

Images

www:

IHC

Features:[1]

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 Chen, YB.; Fine, SW.; Epstein, JI. (Jul 2011). "Mesonephric remnant hyperplasia involving prostate and periprostatic tissue: findings at radical prostatectomy.". Am J Surg Pathol 35 (7): 1054-61. doi:10.1097/PAS.0b013e318218df97. PMID 21606823.
  2. ↑ 2.0 2.1 2.2 2.3 Bostwick, DG.; Qian, J.; Ma, J.; Muir, TE. (Jul 2003). "Mesonephric remnants of the prostate: incidence and histologic spectrum.". Mod Pathol 16 (7): 630-5. doi:10.1097/01.MP.0000074733.10777.78. PMID 12861057.
  3. ↑ Yacoub, M.; Milin, S.; Irani, J.; Fromont, G. (Dec 2009). "Mesonephric remnant hyperplasia: an unusual benign mimicker of prostate cancer.". Ann Diagn Pathol 13 (6): 402-4. doi:10.1016/j.anndiagpath.2009.03.008. PMID 19917478.
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