Difference between revisions of "Thyroid transcription factor-1"

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[[Image:Lung_adenocarcinoma_-_TTF-1_-_high_mag.jpg|thumb|right|250px|TTF-1 staining in [[lung adenocarcinoma]].]]
{{ Infobox immunostain
| Name      = {{PAGENAME}}
| Image     = Lung_adenocarcinoma_-_TTF-1_-_high_mag.jpg
| Width      =
| Caption    = TTF-1 staining in [[lung adenocarcinoma]]. (WC)
| Abbrev    =
| Synonyms  =
| Similar    =
| Clones    =     
| Use        =
| Subspecial = 
| Pattern    = nuclear staining
| Positive  = [[adenocarcinoma of the lung]], [[small cell carcinoma of the lung]], thyroid, [[hepatocellular carcinoma]] (cytoplasmic staining)
| Negative  = [[squamous cell carcinoma of the lung]]
| Other      =
}}
'''Thyroid transcription factor-1''', abbreviated '''TTF-1''' is a transcription factor seen in lung and thyroid.<ref>{{Cite journal  | last1 = Ordóñez | first1 = NG. | title = Thyroid transcription factor-1 is a marker of lung and thyroid carcinomas. | journal = Adv Anat Pathol | volume = 7 | issue = 2 | pages = 123-7 | month = Mar | year = 2000 | doi =  | PMID = 10721419 }}</ref>
'''Thyroid transcription factor-1''', abbreviated '''TTF-1''' is a transcription factor seen in lung and thyroid.<ref>{{Cite journal  | last1 = Ordóñez | first1 = NG. | title = Thyroid transcription factor-1 is a marker of lung and thyroid carcinomas. | journal = Adv Anat Pathol | volume = 7 | issue = 2 | pages = 123-7 | month = Mar | year = 2000 | doi =  | PMID = 10721419 }}</ref>


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==Tumours==
==Tumours==
*[[Lung adenocarcinoma]].<ref>{{Cite journal  | last1 = Yatabe | first1 = Y. | last2 = Mitsudomi | first2 = T. | last3 = Takahashi | first3 = T. | title = TTF-1 expression in pulmonary adenocarcinomas. | journal = Am J Surg Pathol | volume = 26 | issue = 6 | pages = 767-73 | month = Jun | year = 2002 | doi =  | PMID = 12023581 }}</ref>
===Positive staining===
*[[Small cell carcinoma of the lung]].
*[[Lung adenocarcinoma]].<ref name=pmid12023581>{{Cite journal  | last1 = Yatabe | first1 = Y. | last2 = Mitsudomi | first2 = T. | last3 = Takahashi | first3 = T. | title = TTF-1 expression in pulmonary adenocarcinomas. | journal = Am J Surg Pathol | volume = 26 | issue = 6 | pages = 767-73 | month = Jun | year = 2002 | doi =  | PMID = 12023581 }}</ref>
**[[Small cell carcinoma of the lung]] ~ 91% positive (157 +ve of 173<ref name=pmid37139017>{{cite journal |authors=Sayeda S, Naqvi A, Begum H, Juergens RA, Finley C, Coschi CH, Cutz JC, Bonert M |title=Prevalence of Thyroid Transcription Factor-1 (TTF-1)-Negative Small Cell Carcinoma and Napsin A Positivity in Small Cell Carcinoma in a Cross-Sectional Study of Lung Core Biopsies |journal=Cureus |volume=15 |issue=4 |pages=e37015 |date=April 2023 |pmid=37139017 |pmc=10151064 |doi=10.7759/cureus.37015 |url=}}</ref>).
**[[Adenocarcinoma of the lung]].
*Thyroid carcinoma.
*[[Hepatocellular carcinoma]] (cytoplasmic staining, nuclei negative).<ref name=pmid22359993>{{Cite journal  | last1 = Mishra | first1 = M. | last2 = Morgan | first2 = V. | last3 = Hamati | first3 = AK. | last4 = Al-Abbadi | first4 = M. | title = Carcinoma of unknown primary: check the liver... thanks to TTF-1. | journal = Tenn Med | volume = 105 | issue = 1 | pages = 35-6, 40 | month = Jan | year = 2012 | doi =  | PMID = 22359993 }}</ref>
* Spindle cell oncocytoma / Pituicytoma / Granular cell tumor of the pituitary. <ref name=pmid23887161> {{Cite journal  | last1 = Mete | first1 = O. | last2 = Lopes | first2 = MB. | last3 = Asa | first3 = SL. | title = Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma. | journal = Am J Surg Pathol | volume = 37 | issue = 11 | pages = 1694-9 | month = Nov | year = 2013 | doi = 10.1097/PAS.0b013e31829723e7 | PMID = 23887161 }}</ref>
*[[Subependymal giant cell astrocytoma]] <ref name=pmid25669749>{{Cite journal  | last1 = Hewer | first1 = E. | last2 = Vajtai | first2 = I. | title = Consistent nuclear expression of thyroid transcription factor 1 in subependymal giant cell astrocytomas suggests lineage-restricted histogenesis. | journal = Clin Neuropathol | volume = 34 | issue = 3 | pages = 128-31 | month =  | year =  | doi = 10.5414/NP300818 | PMID = 25669749 }}</ref>


===Negative===
===Negative staining===
Negative staining:
*[[Squamous cell carcinoma of the lung]].
*[[Squamous cell carcinoma of the lung]].
*[[SMARCA4-deficient non-small cell carcinoma of the lung]] - typically ~ 5% of [[lung adenocarcinoma]] is TTF-1 negative.
**These cases are often [[CK7]] positive, [[HepPar-1]] positive.<ref name=pmid28038711>{{Cite journal  | last1 = Herpel | first1 = E. | last2 = Rieker | first2 = RJ. | last3 = Dienemann | first3 = H. | last4 = Muley | first4 = T. | last5 = Meister | first5 = M. | last6 = Hartmann | first6 = A. | last7 = Warth | first7 = A. | last8 = Agaimy | first8 = A. | title = SMARCA4 and SMARCA2 deficiency in non-small cell lung cancer: immunohistochemical survey of 316 consecutive specimens. | journal = Ann Diagn Pathol | volume = 26 | issue =  | pages = 47-51 | month = Feb | year = 2017 | doi = 10.1016/j.anndiagpath.2016.10.006 | PMID = 28038711 }}</ref>
===Images===
<gallery>
File:Adenocarcinoma-Acinar type TTF1 (5494540752).jpg | TTF1 in pulmonary adenocarcinoma (WC/Yale Rosen).
File:Pituicytoma TTF1.jpg | TTF1 in a [[Pituicytoma]] (WC/jensflorian).
</gallery>


==See also==
==See also==

Latest revision as of 20:50, 27 November 2023

Thyroid transcription factor-1
Immunostain in short

TTF-1 staining in lung adenocarcinoma. (WC)
Normal staining pattern nuclear staining
Positive adenocarcinoma of the lung, small cell carcinoma of the lung, thyroid, hepatocellular carcinoma (cytoplasmic staining)
Negative squamous cell carcinoma of the lung

Thyroid transcription factor-1, abbreviated TTF-1 is a transcription factor seen in lung and thyroid.[1]

Positive staining

  • Nuclear staining.

Normal tissues

Tumours

Positive staining

Negative staining

Images

  • TTF1 in pulmonary adenocarcinoma (WC/Yale Rosen).

  • TTF1 in a Pituicytoma (WC/jensflorian).

See also

References

  1. ↑ Ordóñez, NG. (Mar 2000). "Thyroid transcription factor-1 is a marker of lung and thyroid carcinomas.". Adv Anat Pathol 7 (2): 123-7. PMID 10721419.
  2. ↑ Yatabe, Y.; Mitsudomi, T.; Takahashi, T. (Jun 2002). "TTF-1 expression in pulmonary adenocarcinomas.". Am J Surg Pathol 26 (6): 767-73. PMID 12023581.
  3. ↑ Sayeda S, Naqvi A, Begum H, Juergens RA, Finley C, Coschi CH, Cutz JC, Bonert M (April 2023). "Prevalence of Thyroid Transcription Factor-1 (TTF-1)-Negative Small Cell Carcinoma and Napsin A Positivity in Small Cell Carcinoma in a Cross-Sectional Study of Lung Core Biopsies". Cureus 15 (4): e37015. doi:10.7759/cureus.37015. PMC 10151064. PMID 37139017. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151064/.
  4. ↑ Mishra, M.; Morgan, V.; Hamati, AK.; Al-Abbadi, M. (Jan 2012). "Carcinoma of unknown primary: check the liver... thanks to TTF-1.". Tenn Med 105 (1): 35-6, 40. PMID 22359993.
  5. ↑ Mete, O.; Lopes, MB.; Asa, SL. (Nov 2013). "Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma.". Am J Surg Pathol 37 (11): 1694-9. doi:10.1097/PAS.0b013e31829723e7. PMID 23887161.
  6. ↑ Hewer, E.; Vajtai, I.. "Consistent nuclear expression of thyroid transcription factor 1 in subependymal giant cell astrocytomas suggests lineage-restricted histogenesis.". Clin Neuropathol 34 (3): 128-31. doi:10.5414/NP300818. PMID 25669749.
  7. ↑ Herpel, E.; Rieker, RJ.; Dienemann, H.; Muley, T.; Meister, M.; Hartmann, A.; Warth, A.; Agaimy, A. (Feb 2017). "SMARCA4 and SMARCA2 deficiency in non-small cell lung cancer: immunohistochemical survey of 316 consecutive specimens.". Ann Diagn Pathol 26: 47-51. doi:10.1016/j.anndiagpath.2016.10.006. PMID 28038711.
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