Difference between revisions of "Renal tumours with eosinophilic cytoplasm"
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[[Image: | [[Image:Eosinophilic variant of chromophobe renal cell carcinoma -- very high mag.jpg|thumb|right|A renal tumour with an eosinophilic cytoplasm ([[chromophobe RCC]]). (WC/Nephron)]] | ||
'''[[Renal tumours]] with eosinophilic cytoplasm''', also '''eosinophilic renal tumours''' and '''kidney tumours with eosinophilic cytoplasm''', are relatively common and have a [[differential diagnosis]]. | '''[[Renal tumours]] with eosinophilic cytoplasm''', also '''eosinophilic renal tumours''' and '''kidney tumours with eosinophilic cytoplasm''', are relatively common and have a [[differential diagnosis]]. | ||
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==Rare stuff== | ==Rare stuff== | ||
[[Image:Eosinophilic, solid and cystic renal cell carcinoma - solid -- very high mag.jpg|thumb|right|[[ESC-RCC]], an evolving entity with eosinophilic cytoplasm. [[H&E stain]]. (WC)]] | |||
[[Image:Low grade oncocytic renal tumour -- very high mag.jpg|thumb|right|Low-grade oncocytic renal tumour, an evolving entity with eosinophilic cytoplasm. [[H&E stain]].]] | |||
*[[Angiomyolipoma]], epithelioid. | *[[Angiomyolipoma]], epithelioid. | ||
*[[Xp11.2 translocation carcinoma]]. | *[[Xp11.2 translocation carcinoma]]. | ||
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*[[Acquired cystic disease-associated renal cell carcinoma]].<ref name=pmid25357116/> | *[[Acquired cystic disease-associated renal cell carcinoma]].<ref name=pmid25357116/> | ||
*[[Renal hybrid oncocytic/chromophobe tumour]].<ref name=pmid25357116/> | *[[Renal hybrid oncocytic/chromophobe tumour]].<ref name=pmid25357116/> | ||
*[[Renal oncocytosis]]. | |||
*[[Unclassified renal cell carcinoma]]. | *[[Unclassified renal cell carcinoma]]. | ||
*[[Juxtaglomerular cell tumour]]. | |||
*[[Succinate dehydrogenase-deficient renal cell carcinoma]]. | |||
*[[Eosinophilic solid and cystic renal cell carcinoma]].<ref name=pmid26414221>{{Cite journal | last1 = Trpkov | first1 = K. | last2 = Hes | first2 = O. | last3 = Bonert | first3 = M. | last4 = Lopez | first4 = JI. | last5 = Bonsib | first5 = SM. | last6 = Nesi | first6 = G. | last7 = Comperat | first7 = E. | last8 = Sibony | first8 = M. | last9 = Berney | first9 = DM. | title = Eosinophilic, Solid, and Cystic Renal Cell Carcinoma: Clinicopathologic Study of 16 Unique, Sporadic Neoplasms Occurring in Women. | journal = Am J Surg Pathol | volume = | issue = | pages = | month = Sep | year = 2015 | doi = 10.1097/PAS.0000000000000508 | PMID = 26414221 }}</ref> | |||
*[[ALK translocation renal cell carcinoma]].<ref name=ref27554841 >{{Cite journal | last1 = Jeanneau | first1 = M. | last2 = Gregoire | first2 = V. | last3 = Desplechain | first3 = C. | last4 = Escande | first4 = F. | last5 = Tica | first5 = DP. | last6 = Aubert | first6 = S. | last7 = Leroy | first7 = X. | title = ALK rearrangements-associated renal cell carcinoma (RCC) with unique pathological features in an adult. | journal = Pathol Res Pract | volume = 212 | issue = 11 | pages = 1064-1066 | month = Nov | year = 2016 | doi = 10.1016/j.prp.2016.07.015 | PMID = 27554841 }}</ref> | |||
===Proposed entities=== | ===Proposed entities=== | ||
*[[Follicular thyroid-like renal cell carcinoma]].<ref name=pmid25357116/> | *[[Follicular thyroid-like renal cell carcinoma]].<ref name=pmid25357116/> | ||
*[[ | *[[Eosinophilic vacuolated tumour]] - previously ''high-grade oncocytic renal tumour''. | ||
*[[Papillary renal neoplasm with reverse polarity]] (PRNRP).<ref name=pmid31135486>{{cite journal |authors=Al-Obaidy KI, Eble JN, Cheng L, Williamson SR, Sakr WA, Gupta N, Idrees MT, Grignon DJ |title=Papillary Renal Neoplasm With Reverse Polarity: A Morphologic, Immunohistochemical, and Molecular Study |journal=Am J Surg Pathol |volume=43 |issue=8 |pages=1099–1111 |date=August 2019 |pmid=31135486 |doi=10.1097/PAS.0000000000001288 |url=}}</ref> | |||
*[[Low-grade oncocytic renal tumour]] (renal oncocytic tumour that is CD117 negative and CK7 positive). | |||
==See also== | |||
*[[Clear cells in the kidney]]. | |||
==References== | ==References== | ||
Latest revision as of 16:28, 22 January 2024
A renal tumour with an eosinophilic cytoplasm (chromophobe RCC). (WC/Nephron)
Renal tumours with eosinophilic cytoplasm, also eosinophilic renal tumours and kidney tumours with eosinophilic cytoplasm, are relatively common and have a differential diagnosis.
Common
- Renal oncocytoma.
- Chromophobe renal cell carcinoma, eosinophilic variant.
Less common
- Clear cell renal cell carcinoma, eosinophilic variant[1] - often high-grade/aggressive tumours.
- Papillary renal cell carcinoma, oncocytic variant.[2]
Rare stuff
Low-grade oncocytic renal tumour, an evolving entity with eosinophilic cytoplasm. H&E stain.
- Angiomyolipoma, epithelioid.
- Xp11.2 translocation carcinoma.
- Hereditary leiomyomatosis renal cell carcinoma syndrome associated renal cell carcinoma.[3]
- Tubulocystic carcinoma.[3]
- Acquired cystic disease-associated renal cell carcinoma.[3]
- Renal hybrid oncocytic/chromophobe tumour.[3]
- Renal oncocytosis.
- Unclassified renal cell carcinoma.
- Juxtaglomerular cell tumour.
- Succinate dehydrogenase-deficient renal cell carcinoma.
- Eosinophilic solid and cystic renal cell carcinoma.[4]
- ALK translocation renal cell carcinoma.[5]
Proposed entities
- Follicular thyroid-like renal cell carcinoma.[3]
- Eosinophilic vacuolated tumour - previously high-grade oncocytic renal tumour.
- Papillary renal neoplasm with reverse polarity (PRNRP).[6]
- Low-grade oncocytic renal tumour (renal oncocytic tumour that is CD117 negative and CK7 positive).
See also
References
- ↑ Engel, U.; Horn, T. (1991). "Eosinophilic renal cell tumours. A study on tumour heterogeneity with special emphasis on oncocytes.". Scand J Urol Nephrol 25 (4): 297-301. PMID 1780705.
- ↑ Xia, QY.; Rao, Q.; Shen, Q.; Shi, SS.; Li, L.; Liu, B.; Zhang, J.; Wang, YF. et al. (2013). "Oncocytic papillary renal cell carcinoma: a clinicopathological study emphasizing distinct morphology, extended immunohistochemical profile and cytogenetic features.". Int J Clin Exp Pathol 6 (7): 1392-9. PMID 23826421.
- ↑ 3.0 3.1 3.2 3.3 3.4 Kryvenko, ON.; Jorda, M.; Argani, P.; Epstein, JI. (Nov 2014). "Diagnostic approach to eosinophilic renal neoplasms.". Arch Pathol Lab Med 138 (11): 1531-41. doi:10.5858/arpa.2013-0653-RA. PMID 25357116.
- ↑ Trpkov, K.; Hes, O.; Bonert, M.; Lopez, JI.; Bonsib, SM.; Nesi, G.; Comperat, E.; Sibony, M. et al. (Sep 2015). "Eosinophilic, Solid, and Cystic Renal Cell Carcinoma: Clinicopathologic Study of 16 Unique, Sporadic Neoplasms Occurring in Women.". Am J Surg Pathol. doi:10.1097/PAS.0000000000000508. PMID 26414221.
- ↑ Jeanneau, M.; Gregoire, V.; Desplechain, C.; Escande, F.; Tica, DP.; Aubert, S.; Leroy, X. (Nov 2016). "ALK rearrangements-associated renal cell carcinoma (RCC) with unique pathological features in an adult.". Pathol Res Pract 212 (11): 1064-1066. doi:10.1016/j.prp.2016.07.015. PMID 27554841.
- ↑ Al-Obaidy KI, Eble JN, Cheng L, Williamson SR, Sakr WA, Gupta N, Idrees MT, Grignon DJ (August 2019). "Papillary Renal Neoplasm With Reverse Polarity: A Morphologic, Immunohistochemical, and Molecular Study". Am J Surg Pathol 43 (8): 1099–1111. doi:10.1097/PAS.0000000000001288. PMID 31135486.