Difference between revisions of "Syphilis"
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==General== | ==General== | ||
*Classically affects the [[testis]] before the epididymis.<ref name=Ref_WMSP364>{{Ref WMSP|364}}</ref> | *Classically affects the [[testis]] before the epididymis.<ref name=Ref_WMSP364>{{Ref WMSP|364}}</ref> | ||
**[[Tuberculosis]]<ref name=pmid19468469>{{Cite journal | last1 = Das | first1 = P. | last2 = Ahuja | first2 = A. | last3 = Gupta | first3 = SD. | title = Incidence, etiopathogenesis and pathological aspects of genitourinary tuberculosis in India: A journey revisited. | journal = Indian J Urol | volume = 24 | issue = 3 | pages = 356-61 | month = Jul | year = 2008 | doi = 10.4103/0970-1591.42618 | PMID = 19468469 }}</ref> and gonorrhea affect the epididymis before the testis. | **[[Tuberculosis]]<ref name=pmid19468469>{{Cite journal | last1 = Das | first1 = P. | last2 = Ahuja | first2 = A. | last3 = Gupta | first3 = SD. | title = Incidence, etiopathogenesis and pathological aspects of genitourinary tuberculosis in India: A journey revisited. | journal = Indian J Urol | volume = 24 | issue = 3 | pages = 356-61 | month = Jul | year = 2008 | doi = 10.4103/0970-1591.42618 | PMID = 19468469 }}</ref> and gonorrhea usually affect the epididymis before the testis. | ||
*Considered one of the [[TORCH infections]]. | *Considered one of the [[TORCH infections]]. | ||
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==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
*Plasma cells - '''key feature'''.<ref name=pmid18948765>{{Cite journal | last1 = Brinster | first1 = NK. | title = Dermatopathology for the surgical pathologist: a pattern-based approach to the diagnosis of inflammatory skin disorders (part II). | journal = Adv Anat Pathol | volume = 15 | issue = 6 | pages = 350-69 | month = Nov | year = 2008 | doi = 10.1097/PAP.0b013e31818b1ac6 | PMID = 18948765 }}</ref> | *[[Plasma cells]] - '''key feature'''.<ref name=pmid18948765>{{Cite journal | last1 = Brinster | first1 = NK. | title = Dermatopathology for the surgical pathologist: a pattern-based approach to the diagnosis of inflammatory skin disorders (part II). | journal = Adv Anat Pathol | volume = 15 | issue = 6 | pages = 350-69 | month = Nov | year = 2008 | doi = 10.1097/PAP.0b013e31818b1ac6 | PMID = 18948765 }}</ref> | ||
*Spirochetes - '''diagnostic'''. | *Spirochetes - '''diagnostic'''. | ||
*+/-[[Granulomas]]<ref name=Ref_PCPBoD8_47>{{Ref PCPBoD8|47}}</ref> - ''gumma'' - in the tertiary phase.<ref>URL: [http://pediatrics.aappublications.org/cgi/content/full/104/1/e4 http://pediatrics.aappublications.org/cgi/content/full/104/1/e4]. Accessed on: 17 November 2010.</ref> | *+/-[[Granulomas]]<ref name=Ref_PCPBoD8_47>{{Ref PCPBoD8|47}}</ref> - ''gumma'' - in the tertiary phase.<ref>URL: [http://pediatrics.aappublications.org/cgi/content/full/104/1/e4 http://pediatrics.aappublications.org/cgi/content/full/104/1/e4]. Accessed on: 17 November 2010.</ref> | ||
DDx: | |||
*[[Plasma cell neoplasm]]. | |||
*Reactive changes. | |||
*[[Zoon balanitis]]. | |||
*Other spirochetes, e.g. ''Borrelia burgdorferi''. | |||
==[[Stains]]== | |||
*[[Dieterle stain]]. | *[[Dieterle stain]]. | ||
Image | ===Image=== | ||
<gallery> | |||
Image:Treponema_pallidum_-_very_high_mag_-_extreme_crop.jpg | T. pallidum - very high mag. cropped. [[Dieterle stain]]. (WC) | |||
Image:Treponema_pallidum_-_very_high_mag.jpg | T. pallidum - very high mag. [[Dieterle stain]]. (WC) | |||
</gallery> | |||
==See also== | ==See also== | ||
| Line 27: | Line 36: | ||
*[[Intestinal spirochetosis]]. | *[[Intestinal spirochetosis]]. | ||
*[[Inflammatory skin disorders]]. | *[[Inflammatory skin disorders]]. | ||
*[[Granulomatous orchitis]]. | |||
==References== | ==References== | ||
Latest revision as of 00:15, 26 March 2024
Syphilis is the infectious disease caused by Treponema pallidum.
General
- Classically affects the testis before the epididymis.[1]
- Tuberculosis[2] and gonorrhea usually affect the epididymis before the testis.
- Considered one of the TORCH infections.
Gross
Aorta:
- Wrinkled intimal surface - "tree bark" appearance.[3]
Microscopic
Features:
- Plasma cells - key feature.[4]
- Spirochetes - diagnostic.
- +/-Granulomas[5] - gumma - in the tertiary phase.[6]
DDx:
- Plasma cell neoplasm.
- Reactive changes.
- Zoon balanitis.
- Other spirochetes, e.g. Borrelia burgdorferi.
Stains
Image
T. pallidum - very high mag. cropped. Dieterle stain. (WC)
T. pallidum - very high mag. Dieterle stain. (WC)
See also
- Vascular disease.
- Microorganisms.
- Intestinal spirochetosis.
- Inflammatory skin disorders.
- Granulomatous orchitis.
References
- ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 364. ISBN 978-0781765275.
- ↑ Das, P.; Ahuja, A.; Gupta, SD. (Jul 2008). "Incidence, etiopathogenesis and pathological aspects of genitourinary tuberculosis in India: A journey revisited.". Indian J Urol 24 (3): 356-61. doi:10.4103/0970-1591.42618. PMID 19468469.
- ↑ Rose, Alan G. (2008). Atlas of Gross Pathology with Histologic Correlation (1st ed.). Cambridge University Press. pp. 80. ISBN 978-0521868792.
- ↑ Brinster, NK. (Nov 2008). "Dermatopathology for the surgical pathologist: a pattern-based approach to the diagnosis of inflammatory skin disorders (part II).". Adv Anat Pathol 15 (6): 350-69. doi:10.1097/PAP.0b013e31818b1ac6. PMID 18948765.
- ↑ Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 47. ISBN 978-1416054542.
- ↑ URL: http://pediatrics.aappublications.org/cgi/content/full/104/1/e4. Accessed on: 17 November 2010.