Difference between revisions of "Hibernoma"

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#redirect [[Adipocytic_tumours#Hibernoma]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Hibernoma1.jpg
| Width      =
| Caption    = Hibernoma. [[H&E stain]].
| Micro      = large polygonal/oval cells with central & small nucleus; nucleoli typically prominent; cytoplasm  multivacuolated, oval, eosinophilic, granular
| Subtypes  =
| LMDDx      = reaction to silicone implant
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      = lobulated lesion, light-brown, usually extremities
| Grossing  =
| Site      = cervical-supraclavicular, periaortic - both thorax and the abdomen, perirenal; see ''[[soft tissue lesions|soft tissue]]'' - [[adipocytic lesions]]
| Assdx      =
| Syndromes  =
| Clinicalhx = typically young adults
| Signs      =
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign
| Other      =
| ClinDDx    = [[Lipoma]]
}}
'''Hibernoma''', also '''tumour of [[brown fat]]''',<ref>{{Cite journal  | last1 = SHUTE | first1 = D. | title = Tumours of brown fat. | journal = Can Med Assoc J | volume = 71 | issue = 5 | pages = 484-5 | month = Nov | year = 1954 | doi =  | PMID = 13209434 }}</ref> is an uncommon [[adipocytic tumour]].


==General==
*Consists of ''brown fat'' (present in the infants to generate heat).<ref name=Ref_WMSP605>{{Ref WMSP|605}}</ref>
*Benign.
*Usually asymptomatic.<ref name=pmid19131775>{{cite journal |author=Ahmed SA, Schuller I |title=Pediatric hibernoma: a case review |journal=J. Pediatr. Hematol. Oncol. |volume=30 |issue=12 |pages=900–1 |year=2008 |month=December |pmid=19131775 |doi=10.1097/MPH.0b013e318184e6dd |url=}}</ref>
Epidemiology:
*Young adults - disappears with age.<ref name=pmid31281288>{{cite journal |authors=Zoico E, Rubele S, De Caro A, Nori N, Mazzali G, Fantin F, Rossi A, Zamboni M |title=Brown and Beige Adipose Tissue and Aging |journal=Front Endocrinol (Lausanne) |volume=10 |issue= |pages=368 |date=2019 |pmid=31281288 |pmc=6595248 |doi=10.3389/fendo.2019.00368 |url=}}</ref>
==Gross==
*Well-circumscribed.
*Lobulated and light-brown on sectioning.
Locations:<ref name=pmid31281288/>
*Cervical-supraclavicular.
*Periaortic - both thorax and the abdomen.
*Perirenal.
==Microscopic==
Features:<ref name=pmid9537018>{{cite journal |author=Chen DY, Wang CM, Chan HL |title=Hibernoma. Case report and literature review |journal=Dermatol Surg |volume=24 |issue=3 |pages=393–5 |year=1998 |month=March |pmid=9537018 |doi= |url=}}</ref>
*Large polygonal/oval cells:
**Nucleus - central & small.<ref>[http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675(06)70271-6 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675(06)70271-6]</ref>
***Nucleoli typically prominent.<ref>[http://surgpathcriteria.stanford.edu/softfat/hibernoma/ http://surgpathcriteria.stanford.edu/softfat/hibernoma/]</ref>
**Cytoplasm - multivacuolated, oval, eosinophilic, granular.
*+/-Prominent blood vessels, central.<ref>URL: [http://radiographics.rsna.org/content/24/5/1433.full http://radiographics.rsna.org/content/24/5/1433.full]. Accessed on: 11 February 2013.</ref>
DDx:
*Reaction to silicone implant.
===Images===
<gallery>
Image:Hibernoma1.jpg | Hibernoma - high mag. (WC)
Image:Hibernoma2.jpg | Hibernoma - intermed mag. (WC)
Image:Hibernoma3.jpg | Hibernoma - low mag. (WC)
</gallery>
==See also==
*[[Adipocytic tumours]].
*[[Lipoma]].
*[[Brown tumour]].
==References==
{{Reflist|2}}
[[Category:Adipocytic tumours]]
[[Category:Diagnosis]]
[[Category:Diagnosis]]

Latest revision as of 16:00, 22 April 2024

Hibernoma
Diagnosis in short

Hibernoma. H&E stain.
LM large polygonal/oval cells with central & small nucleus; nucleoli typically prominent; cytoplasm multivacuolated, oval, eosinophilic, granular
LM DDx reaction to silicone implant
Gross lobulated lesion, light-brown, usually extremities
Site cervical-supraclavicular, periaortic - both thorax and the abdomen, perirenal; see soft tissue - adipocytic lesions
Clinical history typically young adults
Prevalence uncommon
Prognosis benign
Clin. DDx Lipoma

Hibernoma, also tumour of brown fat,[1] is an uncommon adipocytic tumour.

General

  • Consists of brown fat (present in the infants to generate heat).[2]
  • Benign.
  • Usually asymptomatic.[3]

Epidemiology:

  • Young adults - disappears with age.[4]

Gross

  • Well-circumscribed.
  • Lobulated and light-brown on sectioning.

Locations:[4]

  • Cervical-supraclavicular.
  • Periaortic - both thorax and the abdomen.
  • Perirenal.

Microscopic

Features:[5]

  • Large polygonal/oval cells:
    • Nucleus - central & small.[6]
      • Nucleoli typically prominent.[7]
    • Cytoplasm - multivacuolated, oval, eosinophilic, granular.
  • +/-Prominent blood vessels, central.[8]

DDx:

  • Reaction to silicone implant.

Images

  • Hibernoma - high mag. (WC)

  • Hibernoma - intermed mag. (WC)

  • Hibernoma - low mag. (WC)

See also

References

  1. ↑ SHUTE, D. (Nov 1954). "Tumours of brown fat.". Can Med Assoc J 71 (5): 484-5. PMID 13209434.
  2. ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 605. ISBN 978-0781765275.
  3. ↑ Ahmed SA, Schuller I (December 2008). "Pediatric hibernoma: a case review". J. Pediatr. Hematol. Oncol. 30 (12): 900–1. doi:10.1097/MPH.0b013e318184e6dd. PMID 19131775.
  4. ↑ 4.0 4.1 Zoico E, Rubele S, De Caro A, Nori N, Mazzali G, Fantin F, Rossi A, Zamboni M (2019). "Brown and Beige Adipose Tissue and Aging". Front Endocrinol (Lausanne) 10: 368. doi:10.3389/fendo.2019.00368. PMC 6595248. PMID 31281288. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595248/.
  5. ↑ Chen DY, Wang CM, Chan HL (March 1998). "Hibernoma. Case report and literature review". Dermatol Surg 24 (3): 393–5. PMID 9537018.
  6. ↑ http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675(06)70271-6
  7. ↑ http://surgpathcriteria.stanford.edu/softfat/hibernoma/
  8. ↑ URL: http://radiographics.rsna.org/content/24/5/1433.full. Accessed on: 11 February 2013.
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