Difference between revisions of "Hypersensitivity"
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|- | |- | ||
| I | | I | ||
| Immediate h. | | '''Immediate h.''' | ||
| Allergic h. | | Allergic h. | ||
| [[anaphylaxis]], (atopic) bronchial [[asthma]], allergies | | [[anaphylaxis]], (atopic) bronchial [[asthma]], allergies | ||
| IgE | | antibodies (IgE) | ||
| mast cells, inflammation (esp. eosinophils), edema | | mast cells, inflammation (esp. eosinophils), edema | ||
|- | |- | ||
| II | | II | ||
| Antibody mediated h. | | '''Antibody mediated h.''' | ||
| Cytotoxic antibody dependent h. | | Cytotoxic antibody dependent h. | ||
| [[Goodpasture syndrome]] | | [[Goodpasture syndrome]], [[Graves disease]] | ||
| antibodies (IgG, IgM) | | antibodies (IgG, IgM) | ||
| (antibody-mediated) phagocytosis & lysis | | (antibody-mediated) phagocytosis & lysis | ||
|- | |- | ||
| III | | III | ||
| '''Immune complex mediated h.''' | |||
| Immune complex mediated h. | | Immune complex mediated h. | ||
| [[systemic lupus erythematosus]], [[hypersensitivity pneumonititis]], [[rheumatoid arthritis]] | |||
| [[systemic lupus erythematosus]] | |||
| antigen-antibody complex | | antigen-antibody complex | ||
| inflammation, [[vasculitis]] with [[fibrinoid necrosis]] | | inflammation, [[vasculitis]] with [[fibrinoid necrosis]] | ||
|- | |- | ||
| IV | | IV | ||
| Cell-mediated h. | | '''Cell-mediated h.''' | ||
| Delayed-type hypersensitivity | | Delayed-type hypersensitivity | ||
| tuberculosis | | [[tuberculosis]], [[contact dermatitis]], chronic transplant rejection | ||
| activated T cells | | activated T cells | ||
| perivascular inflammation, [[granuloma]]s | | perivascular inflammation, [[granuloma]]s | ||
| Line 43: | Line 43: | ||
Memory device ''ACID'':<ref>URL: [http://www.saintcyr.com/2001/mnemonic.html http://www.saintcyr.com/2001/mnemonic.html]. Accessed on: 13 November 2011.</ref> | Memory device ''ACID'':<ref>URL: [http://www.saintcyr.com/2001/mnemonic.html http://www.saintcyr.com/2001/mnemonic.html]. Accessed on: 13 November 2011.</ref> | ||
*Allergic, Cytotoxic-mediated, Immune-complex disease, Delayed hypersensitivity. | *Allergic, Cytotoxic-mediated, Immune-complex disease, Delayed hypersensitivity. | ||
==See also== | ==See also== | ||
*[[Hypersensitivity pneumonitis]]. | *[[Hypersensitivity pneumonitis]]. | ||
Revision as of 18:53, 13 November 2011
Hypersensitivity is a thingy one may get quized on.
Gell & Goombs classification
| Type (I-IV) | Formal name[1] | Name | Example | Mediator | Pathology |
|---|---|---|---|---|---|
| I | Immediate h. | Allergic h. | anaphylaxis, (atopic) bronchial asthma, allergies | antibodies (IgE) | mast cells, inflammation (esp. eosinophils), edema |
| II | Antibody mediated h. | Cytotoxic antibody dependent h. | Goodpasture syndrome, Graves disease | antibodies (IgG, IgM) | (antibody-mediated) phagocytosis & lysis |
| III | Immune complex mediated h. | Immune complex mediated h. | systemic lupus erythematosus, hypersensitivity pneumonititis, rheumatoid arthritis | antigen-antibody complex | inflammation, vasculitis with fibrinoid necrosis |
| IV | Cell-mediated h. | Delayed-type hypersensitivity | tuberculosis, contact dermatitis, chronic transplant rejection | activated T cells | perivascular inflammation, granulomas |
Memory device ACID:[2]
- Allergic, Cytotoxic-mediated, Immune-complex disease, Delayed hypersensitivity.
See also
References
- ↑ Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 110. ISBN 978-1416054542.
- ↑ URL: http://www.saintcyr.com/2001/mnemonic.html. Accessed on: 13 November 2011.