Difference between revisions of "Choroid plexus carcinoma"

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#redirect [[Neuropathology_tumours#Choroid_plexus_carcinoma]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = choroidplexuscarcinoma.png
| Width      =
| Caption    = Choroid plexus carcinoma. [[H&E stain]].
| Synonyms  =
| Micro      = choroid plexus epithelium with nuclear pleomorphism & high NC ratio, mitoses, necrosis, +/-brain invasion
| Subtypes  =
| LMDDx      = [[choroid plexus papilloma]], atypical plexus papilloma, [[atypical teratoid/rhabdoid tumour]]
| Stains    =
| IHC        = cytokeratins +ve, EMA -ve, INI1 +ve, Ki-67 high
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[brain]] - intraventricular mass, classically posterior fossa
| Assdx      =
| Syndromes  =
| Clinicalhx = typically children
| Signs      =
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  =
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Choroid plexus carcinoma''' is an uncommon [[neuropathology tumour]] and the malignant counter part of [[choroid plexus papilloma]].
 
==General==
*Usually pediatric population.
*Malignant counterpart of ''[[choroid plexus papilloma]]''.<ref name=pmid19679976>{{Cite journal  | last1 = Singh | first1 = A. | last2 = Vermani | first2 = S. | last3 = Shruti | first3 = S. | title = Choroid plexus carcinoma: report of two cases. | journal = Indian J Pathol Microbiol | volume = 52 | issue = 3 | pages = 405-7 | month =  | year =  | doi = 10.4103/0377-4929.55009 | PMID = 19679976 }}</ref>
*Poor prognosis - WHO grade III.<ref name=pmid20644273>{{Cite journal  | last1 = Menon | first1 = G. | last2 = Nair | first2 = SN. | last3 = Baldawa | first3 = SS. | last4 = Rao | first4 = RB. | last5 = Krishnakumar | first5 = KP. | last6 = Gopalakrishnan | first6 = CV. | title = Choroid plexus tumors: an institutional series of 25 patients. | journal = Neurol India | volume = 58 | issue = 3 | pages = 429-35 | month =  | year =  | doi = 10.4103/0028-3886.66455 | PMID = 20644273 |URL = http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2010;volume=58;issue=3;spage=429;epage=435;aulast=Menon }}</ref>
*Classically posterior fossa.
*Intraventricular mass.
 
==Microscopic==
Features:<ref name=pmid19679976/>
*Choroid plexus epithelium with [[nuclear pleomorphism]] & high [[NC ratio]].
*Mitoses.
*Necrosis.
*+/-Brain invasion.
 
DDx:
*[[Choroid plexus papilloma]].
*Atypical plexus papilloma - has features intermediate between ''choroid plexus papilloma'' and ''choroid plexus carcinoma''.<ref name=pmid20644273/>
*[[Atypical teratoid/rhabdoid tumour]].
 
===Images===
<gallery>
Image:Choroidplexuscarcinoma.png | CPC. (WC/Martin Hasselblatt)
</gallery>
www:
*[http://path.upmc.edu/cases/case198/micro.html Choroid plexus carcinoma - several images (upmc.edu)].
 
==IHC==
Features:<ref name=pmid20644273/>
*Cytokeratins +ve.
*EMA usu. -ve.
*GFAP -ve (~20% +ve).
*Ki-67 high.
**Useful to diff. from benign counterpart.
*INI1 +ve.
 
==See also==
*[[Neuropathology tumours]].
 
==References==
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Neuropathology tumours]]

Latest revision as of 06:20, 10 December 2014

Choroid plexus carcinoma
Diagnosis in short

Choroid plexus carcinoma. H&E stain.
LM choroid plexus epithelium with nuclear pleomorphism & high NC ratio, mitoses, necrosis, +/-brain invasion
LM DDx choroid plexus papilloma, atypical plexus papilloma, atypical teratoid/rhabdoid tumour
IHC cytokeratins +ve, EMA -ve, INI1 +ve, Ki-67 high
Site brain - intraventricular mass, classically posterior fossa
Clinical history typically children
Prevalence uncommon

Choroid plexus carcinoma is an uncommon neuropathology tumour and the malignant counter part of choroid plexus papilloma.

General

  • Usually pediatric population.
  • Malignant counterpart of choroid plexus papilloma.[1]
  • Poor prognosis - WHO grade III.[2]
  • Classically posterior fossa.
  • Intraventricular mass.

Microscopic

Features:[1]

DDx:

Images

  • CPC. (WC/Martin Hasselblatt)

www:

IHC

Features:[2]

  • Cytokeratins +ve.
  • EMA usu. -ve.
  • GFAP -ve (~20% +ve).
  • Ki-67 high.
    • Useful to diff. from benign counterpart.
  • INI1 +ve.

See also

References

  1. ↑ 1.0 1.1 Singh, A.; Vermani, S.; Shruti, S.. "Choroid plexus carcinoma: report of two cases.". Indian J Pathol Microbiol 52 (3): 405-7. doi:10.4103/0377-4929.55009. PMID 19679976.
  2. ↑ 2.0 2.1 2.2 Menon, G.; Nair, SN.; Baldawa, SS.; Rao, RB.; Krishnakumar, KP.; Gopalakrishnan, CV.. "Choroid plexus tumors: an institutional series of 25 patients.". Neurol India 58 (3): 429-35. doi:10.4103/0028-3886.66455. PMID 20644273.
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