Difference between revisions of "Angiomyofibroblastoma"

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#redirect [[Soft_tissue_lesions#Angiomyofibroblastoma]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Angiomyofibroblastoma humpath 4.jpg
| Width      =
| Caption    = Angiomyofibroblastoma. [[H&E stain]].
| Synonyms  =
| Micro      = hypercellular zones and hypocellular edematous zones, small blood vessels (~20 micrometers) - no large blood vessels, [[myxoid stroma]], small stellate cell/spindle cells without significant nuclear atypia
| Subtypes  =
| LMDDx      = [[aggressive angiomyxoma]]
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      = well-circumscribed
| Grossing  =
| Site      = female pelvis ([[vulva]]), case reports of similar lesion in males
| Assdx      =
| Syndromes  =
| Clinicalhx = slow growing, usu. not painful
| Signs      =
| Symptoms  =
| Prevalence = very rare
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  =
| Other      =
| ClinDDx    = [[Bartholin cyst]], [[aggressive angiomyxoma]]
| Tx        =
}}
'''Angiomyofibroblastoma''', abbreviated '''AMF''',<ref name=pmid15782077>{{cite journal |author=Cao D, Srodon M, Montgomery EA, Kurman RJ |title=Lipomatous variant of angiomyofibroblastoma: report of two cases and review of the literature |journal=Int. J. Gynecol. Pathol. |volume=24 |issue=2 |pages=196–200 |year=2005 |month=April |pmid=15782077 |doi= |url=}}</ref> is rare uncommon [[soft tissue lesion]] of the [[vulva]].
 
==General==
*Uncommon.
*Similar lesions reported in males.<ref name=pmid24396463>{{Cite journal  | last1 = Ding | first1 = G. | last2 = Yu | first2 = Y. | last3 = Jin | first3 = M. | last4 = Xu | first4 = J. | last5 = Zhang | first5 = Z. | title = Angiomyofibroblastoma-like tumor of the scrotum: A case report and literature review. | journal = Oncol Lett | volume = 7 | issue = 2 | pages = 435-438 | month = Feb | year = 2014 | doi = 10.3892/ol.2013.1741 | PMID = 24396463 }}</ref><ref>{{Cite journal  | last1 = Butt | first1 = Z. | last2 = Slatnik | first2 = J. | last3 = Estey | first3 = EP. | title = Robotic assisted laparoscopic excision of a pelvic angiomyofibroblastoma-like tumor. | journal = Can J Urol | volume = 20 | issue = 6 | pages = 7067-9 | month = Dec | year = 2013 | doi =  | PMID = 24331351 }}</ref>
 
Clinical:<ref name=pmid24328028/>
*Slow growing.
*Uncommonly recur.
*Usually painless.
 
Clinical DDx:
*[[Bartholin cyst]].
 
==Gross==
*[[Vulva|Vulvar lesion]].
*Well-circumscribed.<ref name=pmid24328028>{{Cite journal  | last1 = Seo | first1 = JW. | last2 = Lee | first2 = KA. | last3 = Yoon | first3 = NR. | last4 = Lee | first4 = JW. | last5 = Kim | first5 = BG. | last6 = Bae | first6 = DS. | title = Angiomyofibroblastoma of the vulva. | journal = Obstet Gynecol Sci | volume = 56 | issue = 5 | pages = 349-51 | month = Sep | year = 2013 | doi = 10.5468/ogs.2013.56.5.349 | PMID = 24328028 }}</ref>
 
==Microscopic==
Features:<ref name=pmid1314521>{{Cite journal  | last1 = Fletcher | first1 = CD. | last2 = Tsang | first2 = WY. | last3 = Fisher | first3 = C. | last4 = Lee | first4 = KC. | last5 = Chan | first5 = JK. | title = Angiomyofibroblastoma of the vulva. A benign neoplasm distinct from aggressive angiomyxoma. | journal = Am J Surg Pathol | volume = 16 | issue = 4 | pages = 373-82 | month = Apr | year = 1992 | doi =  | PMID = 1314521 }}</ref>
*Hypercellular zones and hypocellular edematous zones.
*Small blood vessels (~20 micrometers) - no large blood vessels - '''key feature'''.
*[[Myxoid stroma]] - '''key feature'''.
*Small stellate cell/spindle cells without significant nuclear atypia.
 
DDx:
*[[Aggressive angiomyxoma]] - less cellular, large blood vessels.
 
===Images===
<gallery>
Image:Angiomyofibroblastoma humpath 1.jpg | AMF - low mag.
Image:Angiomyofibroblastoma humpath 2.jpg | AMF - intermed. mag.
Image:Angiomyofibroblastoma humpath 3.jpg | AMF - high mag.
Image:Angiomyofibroblastoma humpath 4.jpg | AMF - very high mag.
</gallery>
www:
*[http://www.webpathology.com/image.asp?case=544&n=4 Angiomyofibroblastoma (webpathology.com)]
*[http://www.webpathology.com/image.asp?n=5&Case=544 Angiomyofibroblastoma - high mag. (webpathology.com)].
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881198/figure/f2-ol-07-02-0435/ Angiomyofibroblastoma-like tumour of scrotum (nih.gov)].<ref name=pmid24396463/>
 
==IHC==
*Desmin +ve.<ref name=pmid24328028/>
*Vimentin +ve.<ref name=pmid24328028/>
*SMA +ve.
*S-100 -ve.
*Actin -ve.
*CD34 -ve.
 
==See also==
*[[Soft tissue lesions]].
*[[Vulva]].
*[[Scrotum]].
 
==References==
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Soft tissue lesions]]

Latest revision as of 07:56, 8 May 2014

Angiomyofibroblastoma
Diagnosis in short

Angiomyofibroblastoma. H&E stain.
LM hypercellular zones and hypocellular edematous zones, small blood vessels (~20 micrometers) - no large blood vessels, myxoid stroma, small stellate cell/spindle cells without significant nuclear atypia
LM DDx aggressive angiomyxoma
Gross well-circumscribed
Site female pelvis (vulva), case reports of similar lesion in males
Clinical history slow growing, usu. not painful
Prevalence very rare
Clin. DDx Bartholin cyst, aggressive angiomyxoma

Angiomyofibroblastoma, abbreviated AMF,[1] is rare uncommon soft tissue lesion of the vulva.

General

  • Uncommon.
  • Similar lesions reported in males.[2][3]

Clinical:[4]

  • Slow growing.
  • Uncommonly recur.
  • Usually painless.

Clinical DDx:

Gross

Microscopic

Features:[5]

  • Hypercellular zones and hypocellular edematous zones.
  • Small blood vessels (~20 micrometers) - no large blood vessels - key feature.
  • Myxoid stroma - key feature.
  • Small stellate cell/spindle cells without significant nuclear atypia.

DDx:

Images

  • AMF - low mag.

  • AMF - intermed. mag.

  • AMF - high mag.

  • AMF - very high mag.

www:

IHC

  • Desmin +ve.[4]
  • Vimentin +ve.[4]
  • SMA +ve.
  • S-100 -ve.
  • Actin -ve.
  • CD34 -ve.

See also

References

  1. ↑ Cao D, Srodon M, Montgomery EA, Kurman RJ (April 2005). "Lipomatous variant of angiomyofibroblastoma: report of two cases and review of the literature". Int. J. Gynecol. Pathol. 24 (2): 196–200. PMID 15782077.
  2. ↑ 2.0 2.1 Ding, G.; Yu, Y.; Jin, M.; Xu, J.; Zhang, Z. (Feb 2014). "Angiomyofibroblastoma-like tumor of the scrotum: A case report and literature review.". Oncol Lett 7 (2): 435-438. doi:10.3892/ol.2013.1741. PMID 24396463.
  3. ↑ Butt, Z.; Slatnik, J.; Estey, EP. (Dec 2013). "Robotic assisted laparoscopic excision of a pelvic angiomyofibroblastoma-like tumor.". Can J Urol 20 (6): 7067-9. PMID 24331351.
  4. ↑ 4.0 4.1 4.2 4.3 Seo, JW.; Lee, KA.; Yoon, NR.; Lee, JW.; Kim, BG.; Bae, DS. (Sep 2013). "Angiomyofibroblastoma of the vulva.". Obstet Gynecol Sci 56 (5): 349-51. doi:10.5468/ogs.2013.56.5.349. PMID 24328028.
  5. ↑ Fletcher, CD.; Tsang, WY.; Fisher, C.; Lee, KC.; Chan, JK. (Apr 1992). "Angiomyofibroblastoma of the vulva. A benign neoplasm distinct from aggressive angiomyxoma.". Am J Surg Pathol 16 (4): 373-82. PMID 1314521.
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