Difference between revisions of "Basal cell adenocarcinoma"

From Libre Pathology
Jump to navigation Jump to search
(create with cat.)
 
(→‎Images: fix)
 
(4 intermediate revisions by the same user not shown)
Line 1: Line 1:
#redirect [[Salivary_glands#Basal_cell_adenocarcinoma]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Basal_cell_adenocarcinoma_-_2_-_parotid_gland_-_high_mag.jpg
| Width      =
| Caption    = Basal cell adenocarcinoma. [[H&E stain]].
| Micro      = unencapsulated lesion with basal-like cells, tubular component - within basal component, dense hyaline stroma around tumour cells
| Subtypes  =
| LMDDx      = [[adenoid cystic carcinoma]], [[basal cell adenoma]] - cannot be differentiated on [[cytology]]
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[salivary gland]] - usu. parotid gland
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      = salivary gland mass
| Symptoms  =
| Prevalence = very rare
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = good
| Other      =
| ClinDDx    =
}}
'''Basal cell adenocarcinoma''', abbreviated ''BCAC'', is an uncommon malignant [[salivary gland]] tumour.
 
It should ''not'' be confused with ''[[basal cell carcinoma]]'', a very common tumour of the skin.
==General==
*Very rare.
*Malignant.
*Good prognosis.
*May arise from a ''[[basal cell adenoma]]''.<ref name=pmid8952553/>
 
==Gross==
*Usually in the parotid gland ~90% of cases.<ref name=pmid8952553>{{Cite journal  | last1 = Muller | first1 = S. | last2 = Barnes | first2 = L. | title = Basal cell adenocarcinoma of the salivary glands. Report of seven cases and review of the literature. | journal = Cancer | volume = 78 | issue = 12 | pages = 2471-7 | month = Dec | year = 1996 | doi =  | PMID = 8952553 }}</ref>
 
==Microscopic==
Features:
#Lesion is '''not''' encapsulated - '''key feature'''.
#Basal-like cells:
#*Basophilic cells - '''key feature'''.
#*Usually in nests.
#**May be bilayered tubules ''or'' [[trabeculae]].
#*Large basophilic nucleus.
#*Minimal-to-moderate eosinophilic cytoplasm.
#Stromal cells.
#*Plump spindle cells without significant nuclear atypia.
#**Stromal cell nuclei width ~= diameter [[RBC]].
#*Dense hyaline stroma.
#Tubular component.
#*Within basal component, may be minimal.
 
DDx:
*[[Adenoid cystic carcinoma]].
*[[Basal cell adenoma]] - encapsulated.
*Basaloid [[squamous cell carcinoma]].
 
===Images===
<gallery>
Image:Basal_cell_adenocarcinoma_-_parotid_gland_-_intermed_mag.jpg | BCAC - intermed. mag. (WC/Nephron)
Image:Basal_cell_adenocarcinoma_-_parotid_gland_-_high_mag.jpg | BCAC - high mag. (WC/Nephron)
Image:Basal_cell_adenocarcinoma_-_parotid_gland_-_very_high_mag.jpg | BCAC - very high mag. (WC/Nephron)
Image:Basal_cell_adenocarcinoma_-_2_-_parotid_gland_-_high_mag.jpg | BCAC - high mag. (WC/Nephron)
Image: Basal cell adenocarcinoma - 2 - parotid gland - very high mag.jpg | BCAC - very high mag. (WC/Nephron)
</gallery>
www:
*[http://www.webpathology.com/image.asp?n=5&Case=115 Basal cell adenocarcinoma - intermed. mag. (webpathology.com)].
*[http://www.webpathology.com/image.asp?n=6&Case=115 Basal cell adenocarcinoma - high mag. (webpathology.com)].
 
==IHC==
Features:<ref name=pmid17922602>{{Cite journal  | last1 = Farrell | first1 = T. | last2 = Chang | first2 = YL. | title = Basal cell adenocarcinoma of minor salivary glands. | journal = Arch Pathol Lab Med | volume = 131 | issue = 10 | pages = 1602-4 | month = Oct | year = 2007 | doi = 10.1043/1543-2165(2007)131[1602:BCAOMS]2.0.CO;2 | PMID = 17922602 }}</ref>
*CK7 +ve (strong).
*S100 +ve/-ve.
 
==See also==
*[[Salivary glands]].
*[[Head and neck pathology]].
 
==References==
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Salivary gland]]
[[Category:Head and neck pathology]]

Latest revision as of 13:26, 30 July 2013

Basal cell adenocarcinoma
Diagnosis in short

Basal cell adenocarcinoma. H&E stain.
LM unencapsulated lesion with basal-like cells, tubular component - within basal component, dense hyaline stroma around tumour cells
LM DDx adenoid cystic carcinoma, basal cell adenoma - cannot be differentiated on cytology
Site salivary gland - usu. parotid gland
Signs salivary gland mass
Prevalence very rare
Prognosis good

Basal cell adenocarcinoma, abbreviated BCAC, is an uncommon malignant salivary gland tumour.

It should not be confused with basal cell carcinoma, a very common tumour of the skin.

General

Gross

  • Usually in the parotid gland ~90% of cases.[1]

Microscopic

Features:

  1. Lesion is not encapsulated - key feature.
  2. Basal-like cells:
    • Basophilic cells - key feature.
    • Usually in nests.
    • Large basophilic nucleus.
    • Minimal-to-moderate eosinophilic cytoplasm.
  3. Stromal cells.
    • Plump spindle cells without significant nuclear atypia.
      • Stromal cell nuclei width ~= diameter RBC.
    • Dense hyaline stroma.
  4. Tubular component.
    • Within basal component, may be minimal.

DDx:

Images

  • BCAC - intermed. mag. (WC/Nephron)

  • BCAC - high mag. (WC/Nephron)

  • BCAC - very high mag. (WC/Nephron)

  • BCAC - high mag. (WC/Nephron)

  • BCAC - very high mag. (WC/Nephron)

www:

IHC

Features:[2]

  • CK7 +ve (strong).
  • S100 +ve/-ve.

See also

References

  1. ↑ 1.0 1.1 Muller, S.; Barnes, L. (Dec 1996). "Basal cell adenocarcinoma of the salivary glands. Report of seven cases and review of the literature.". Cancer 78 (12): 2471-7. PMID 8952553.
  2. ↑ Farrell, T.; Chang, YL. (Oct 2007). "Basal cell adenocarcinoma of minor salivary glands.". Arch Pathol Lab Med 131 (10): 1602-4. doi:10.1043/1543-2165(2007)131[1602:BCAOMS]2.0.CO;2. PMID 17922602.
Retrieved from "https://librepathology.org/w/index.php?title=Basal_cell_adenocarcinoma&oldid=23484"